Neuropsychological and P300 abnormalities in schizophrenics and their relatives

Schizophrenic subjects (N = 30) performed less well than controls (N = 30) on neuropsychological tests sensitive to frontal and temporal lobe impairment and showed prolonged latency of the P300 event-related potential. Relatives of schizophrenic probands were also tested. Relatives with an abnormal P300 had a similar range of neuropsychological deficits as were found in the schizophrenic group and relatives with a normal P300 response performed as well as the normal control group. The results suggest that neurophysiological and neuropsychological testing of relatives may help to clarify the mode of inheritance of schizophrenia in some families.

[1]  Michael Petrides,et al.  Behavioural effects of frontal-lobe lesions in man , 1984, Trends in Neurosciences.

[2]  F. Smith,et al.  Nuclear Magnetic Resonance Brain Imaging in Chronic Schizophrenia , 1987, British Journal of Psychiatry.

[3]  Pierre Flor-Henry,et al.  Hemisphere asymmetries of function in psychopathology , 1979 .

[4]  Klaus P. Ebmeier,et al.  Late Positive Event Related Potentials in Schizophrenia , 1989 .

[5]  J E Christie,et al.  Changes in Auditory P3 Event-related Potential in Schizophrenia and Depression , 1987, British Journal of Psychiatry.

[6]  D. Blackwood,et al.  P300 abnormality in schizophrenic subtypes. , 1989, Journal of psychiatric research.

[7]  D. Clair,et al.  Magnetic resonance imaging in schizophrenia: Altered brain morphology associated with P300 abnormalities and eye tracking dysfunction , 1991, Biological Psychiatry.

[8]  J. Gruzelier,et al.  Impairments on neuropsychologic tests of temporohippocampal and frontohippocampal functions and word fluency in remitting schizophrenia and affective disorders. , 1988, Archives of general psychiatry.

[9]  D. M. Parker,et al.  Developments in Clinical and Experimental Neuropsychology , 1989 .

[10]  B. Milner.  MEMORY AND THE MEDIAL TEMPORAL REGIONS OF THE BRAIN , 1970 .

[11]  K. Squires,et al.  Long latency event-related components of the auditory evoked potential in dementia. , 1978, Brain : a journal of neurology.

[12]  M. Hamilton.  A RATING SCALE FOR DEPRESSION , 1960, Journal of neurology, neurosurgery, and psychiatry.

[13]  A. Romani,et al.  P300 and CT Scan in Patients with Chronic Schizophrenia , 1987, British Journal of Psychiatry.

[14]  E. Gordon,et al.  The differential diagnosis of dementia using P300 latency , 1986, Biological Psychiatry.

[15]  B. Milner,et al.  Interhemispheric differences in the localization of psychological processes in man. , 1971, British medical bulletin.

[16]  D. Weinberger,et al.  Neuropathological studies of schizophrenia: a selective review. , 1983, Schizophrenia bulletin.

[17]  C. Kornetsky,et al.  Attention dysfunction in chronic schizophrenia. , 1966, Archives of General Psychiatry.

[18]  L. DeLisi,et al.  Positron Emission Tomography in Schizophrenic Patients with and without Neuroleptic Medication , 1985, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[19]  E. Walker,et al.  Familial schizophrenia. A predictor of neuromotor and attentional abnormalities in schizophrenia. , 1982, Archives of general psychiatry.

[20]  M. Taylor,et al.  Cognitive impairment in schizophrenia. , 1984, The American journal of psychiatry.

[21]  J C Duffy,et al.  Auditory P300 and eye tracking dysfunction in schizophrenic pedigrees. , 1991, Archives of general psychiatry.

[22]  J. Ford,et al.  Clinical application of the P3 component of event-related potentials. II. Dementia, depression and schizophrenia. , 1984, Electroencephalography and clinical neurophysiology.

[23]  J. Brodie,et al.  Regional brain glucose metabolism in chronic schizophrenia. A positron emission transaxial tomographic study. , 1984, Archives of general psychiatry.

[24]  A. Komatani,et al.  Correlation of regional cerebral blood flow with performance on neuropsychological tests in schizophrenic patients , 1990, Schizophrenia Research.

[25]  W. F. Battig,et al.  Handbook of semantic word norms , 1978 .

[26]  H. J. Evans,et al.  No linkage of chromosome 5q11-q13 markers to schizophrenia in Scottish families , 1989, Nature.

[27]  K. Nuechterlein.  Signal detection in vigilance tasks and behavioral attributes among offspring of schizophrenic mothers and among hyperactive children. , 1983, Journal of abnormal psychology.

[28]  R. Malenka,et al.  Impaired central error-correcting behavior in schizophrenia. , 1982, Archives of general psychiatry.

[29]  C. Kestenbaum.  Children at risk for schizophrenia. , 1980, American journal of psychotherapy.

[30]  D. Weinberger,et al.  Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. , 1986, Archives of general psychiatry.

[31]  B. Cornblatt,et al.  Attentional measures in a study of children at high-risk for schizophrenia. , 1978, Journal of psychiatric research.

[32]  I. Whishaw,et al.  Performance of schizophrenic patients on tests sensitive to left or right frontal, temporal, or parietal function in neurological patients. , 1983, The Journal of nervous and mental disease.

[33]  M S Buchsbaum,et al.  Cerebral glucography with positron tomography. Use in normal subjects and in patients with schizophrenia. , 1982, Archives of general psychiatry.

[34]  J. Endicott,et al.  A diagnostic interview: the schedule for affective disorders and schizophrenia. , 1978, Archives of general psychiatry.

[35]  R. Lehman,et al.  Constructional Apraxia and the Minor Hemisphere , 1967 .

[36]  B. Cornblatt,et al.  Sustained attention in children at risk for schizophrenia. Report on a continuous performance test. , 1977, Archives of general psychiatry.

[37]  T. Crow,et al.  CEREBRAL VENTRICULAR SIZE AND COGNITIVE IMPAIRMENT IN CHRONIC SCHIZOPHRENIA , 1976, The Lancet.

[38]  R. Baumgartner,et al.  Magnetic resonance imaging studies of the brains of schizophrenic patients , 1987, Psychiatry Research.

[39]  R. Heaton,et al.  The utility of the Wisconsin Card Sorting Test in detecting and localizing frontal lobe lesions. , 1980, Journal of consulting and clinical psychology.

[40]  K. Pribram,et al.  Biology of memory , 1970 .

[41]  E. Walker,et al.  Attentional and neuromotor functions of schizophrenics, schizoaffectives, and patients with other affective disorders. , 1981, Archives of general psychiatry.

[42]  B. Bogerts,et al.  Basal Ganglia and Limbic System Pathology in Schizophrenia: A Morphometric Study of Brain Volume and Shrinkage , 1985 .

[43]  J. Overall,et al.  The Brief Psychiatric Rating Scale , 1962 .

[44]  M. Reveley,et al.  CT Scans in Schizophrenia , 1985, British Journal of Psychiatry.

[45]  D. Blackwood,et al.  The development of Alzheimer's disease in Down's syndrome assessed by auditory event-related potentials. , 2008, Journal of mental deficiency research.

[46]  M. Albert,et al.  Missile wounds of the brain: Freda Newcombe. Oxford University Press, London, 1969. 145 pp. 42s , 1970 .

[47]  C. Frith,et al.  Towards a Neuropsychology of Schizophrenia , 1988, British Journal of Psychiatry.

[48]  B. Milner.  Effects of Different Brain Lesions on Card Sorting: The Role of the Frontal Lobes , 1963 .