Antioxidant, antiapoptotic, and antifibrotic abilities of L-Arginine ameliorate the testicular dysfunction in diabetic rats.

[1]  Hanaa Tashkandi,et al.  Ellagic acid Nanoparticles Attenuate Oxidative Stress and Testicular Damage in High Fat Diet/Streptozotocin-Induced Diabetic Rats , 2021, Journal of King Saud University - Science.

[2]  N. Giribabu,et al.  Myristic acid defends against testicular oxidative stress, inflammation, apoptosis: Restoration of spermatogenesis, steroidogenesis in diabetic rats. , 2021, Life sciences.

[3]  M. Islam,et al.  Vanillin Exerts Therapeutic Effects against Hyperglycemia-Altered Glucose Metabolism and Purinergic Activities in Testicular Tissues of Diabetic Rats. , 2021, Reproductive toxicology.

[4]  A. Kapucu,et al.  Leptin ameliorates testicular injury by altering expression of nitric oxide synthases in diabetic rats. , 2021, Bratislavske lekarske listy.

[5]  X. Yang,et al.  L-Arginine protects mouse Leydig cells against T-2 toxin-induced apoptosis in vitro , 2020, Toxicology and industrial health.

[6]  Ling-ling Zhao,et al.  Protective effects of ethyl acetate extract from Shorea roxburghii against diabetes induced testicular damage in rats , 2020, Environmental toxicology.

[7]  F. Heydarpour,et al.  Involvement of TGF-β and Autophagy Pathways in Pathogenesis of Diabetes: A Comprehensive Review on Biological and Pharmacological Insights , 2020, Frontiers in Pharmacology.

[8]  Chunmei Li,et al.  L-Arginine alleviates the testosterone reduction in heat-treated mice by upregulating LH secretion, the testicular antioxidant system and expression of steroidogenesis-related genes. , 2020, Reproduction, fertility, and development.

[9]  M. El-Sibai,et al.  Arginine deprivation: a potential therapeutic for cancer cell metastasis? A review , 2020, Cancer Cell International.

[10]  Lijun Zhao,et al.  Transforming Growth Factor-Beta1 in Diabetic Kidney Disease , 2020, Frontiers in Cell and Developmental Biology.

[11]  C. Eleazu,et al.  Oxidative Stress, NF-κB-Mediated Inflammation and Apoptosis in the Testes of Streptozotocin–Induced Diabetic Rats: Combined Protective Effects of Malaysian Propolis and Metformin , 2019, Antioxidants.

[12]  H. Hammes,et al.  Hyperglycemia induces spermatogenic disruption via major pathways of diabetes pathogenesis , 2019, Scientific Reports.

[13]  A. Mohammadi-Sangcheshmeh,et al.  The effect of l-arginine and flaxseed on plasma testosterone concentration, semen quality and some testicular histology parameters in old broiler breeder roosters. , 2019, Theriogenology.

[14]  M. Islam,et al.  Raffia palm (Raphia hookeri) wine extenuates redox imbalance and modulates activities of glycolytic and cholinergic enzymes in hyperglycemia-induced testicular injury in type 2 diabetic rats. , 2019, Journal of food biochemistry.

[15]  D. Elgamal,et al.  Experimental obesity and diabetes reduce male fertility: Potential involvement of hypothalamic Kiss-1, pituitary nitric oxide, serum vaspin and visfatin. , 2019, Pathophysiology : the official journal of the International Society for Pathophysiology.

[16]  O. Olatunji,et al.  Ameliorative effects of Lycium chinensis on male sexual dysfunction and testicular oxidative damage in streptozotocin-induced diabetic rats , 2019, Food Science and Biotechnology.

[17]  P. Mahesh,et al.  Diabetes induces fibrotic changes in the lung through the activation of TGF-β signaling pathways , 2018, Scientific Reports.

[18]  Hongjuan He,et al.  l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway. , 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[19]  C. Deng,et al.  The role of TGF-β/SMAD4 signaling in cancer , 2018, International journal of biological sciences.

[20]  Xiaofang Lu,et al.  Hyperglycemia induced testicular damage in type 2 diabetes mellitus rats exhibiting microcirculation impairments associated with vascular endothelial growth factor decreased via PI3K/Akt pathway , 2018, Oncotarget.

[21]  C. Li,et al.  Dietary l-arginine supplementation improves semen quality and libido of boars under high ambient temperature. , 2017, Animal : an international journal of animal bioscience.

[22]  Nasser S. Abou Khalil,et al.  The protective role of folic acid against testicular dysfunction in lead-intoxicated rat model. , 2017, General physiology and biophysics.

[23]  Jie Zheng,et al.  Diabetes associated with male reproductive system damages: Onset of presentation, pathophysiological mechanisms and drug intervention. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[24]  O. Smithies,et al.  Transforming growth factor-β1 and diabetic nephropathy. , 2016, American journal of physiology. Renal physiology.

[25]  D. Karabulut,et al.  Nitric oxide synthase in diabetic rat testicular tissue and the effects of pentoxifylline therapy , 2016, Systems biology in reproductive medicine.

[26]  E. Davidson,et al.  Rat Models of Diet-Induced Obesity and High Fat/Low Dose Streptozotocin Type 2 Diabetes: Effect of Reversal of High Fat Diet Compared to Treatment with Enalapril or Menhaden Oil on Glucose Utilization and Neuropathic Endpoints , 2015, Journal of diabetes research.

[27]  P. Reddy,et al.  Recovery of lead‐induced suppressed reproduction in male rats by testosterone , 2015, Andrologia.

[28]  J. Steimle,et al.  L-Arginine Supplementation in Type II Diabetic Rats Preserves Renal Function and Improves Insulin Sensitivity by Altering the Nitric Oxide Pathway , 2014, International journal of endocrinology.

[29]  M. Alves,et al.  Diabetes, insulin-mediated glucose metabolism and Sertoli/blood-testis barrier function , 2013, Tissue barriers.

[30]  F. Narin,et al.  Melatonin and Vitamin C Ameliorate Alcohol-Induced Oxidative Stress and eNOS Expression in Rat Kidney , 2012, Renal failure.

[31]  H. Temel,et al.  NO levels in diabetes mellitus: Effects of l-NAME and insulin on LCAT, Na(+)/K(+) ATPase activity and lipid profile. , 2011, Diabetes & metabolic syndrome.

[32]  S. Umathe,et al.  Beneficial effects of L-arginine against diabetes-induced oxidative stress in gastrointestinal tissues in rats , 2009, Pharmacological reports : PR.

[33]  James M. Anderson,et al.  Zonula Occludens‐1 and ‐2 Are Cytosolic Scaffolds That Regulate the Assembly of Cellular Junctions , 2009, Annals of the New York Academy of Sciences.

[34]  P. Oliveira,et al.  Testicular mitochondrial alterations in untreated streptozotocin-induced diabetic rats. , 2009, Mitochondrion.

[35]  N. Uysal,et al.  Effect of Melatonin on Testicular Damage in Streptozotocin-Induced Diabetes Rats , 2008, European Surgical Research.

[36]  P. Liss,et al.  Reduced nitric oxide in diabetic kidneys due to increased hepatic arginine metabolism: implications for renomedullary oxygen availability. , 2008, American journal of physiology. Renal physiology.

[37]  Muralidhara,et al.  Early oxidative stress in testis and epididymal sperm in streptozotocin-induced diabetic mice: its progression and genotoxic consequences. , 2007, Reproductive toxicology.

[38]  C. Shaha.  Modulators of spermatogenic cell survival. , 2007, Society of Reproduction and Fertility supplement.

[39]  L. Monti,et al.  Beneficial effects of a long-term oral L-arginine treatment added to a hypocaloric diet and exercise training program in obese, insulin-resistant type 2 diabetic patients. , 2006, American journal of physiology. Endocrinology and metabolism.

[40]  A. Agarwal,et al.  Review article Oxidative stress and antioxidants in male infertility: a difficult balance , 2005 .

[41]  M. Abou-Seif,et al.  Evaluation of some biochemical changes in diabetic patients. , 2004, Clinica chimica acta; international journal of clinical chemistry.

[42]  T. Christopher,et al.  Critical Timing of L‐arginine Treatment in Post‐Ischemic Myocardial Apoptosis‐Role of NOS Isoforms: 171 , 2004, Cardiovascular research.

[43]  M. Dikshit,et al.  Vascular regulation by the L-arginine metabolites, nitric oxide and agmatine. , 2004, Pharmacological research.

[44]  S. Martini,et al.  NO mediates antifibrotic actions of L-arginine supplementation following induction of anti-thy1 glomerulonephritis. , 2003, Kidney international.

[45]  N. Pant,et al.  Testicular and spermatotoxic effects of quinalphos in rats , 2003, Journal of applied toxicology : JAT.

[46]  D. Wink,et al.  A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. , 2001, Nitric oxide : biology and chemistry.

[47]  S. Chakrabarti,et al.  Apoptotic germ-cell death and testicular damage in experimental diabetes: prevention by endothelin antagonism , 2000, Urological Research.

[48]  U. Walter,et al.  NO at work , 1994, Cell.

[49]  F. Ziyadeh.  Renal tubular basement membrane and collagen type IV in diabetes mellitus. , 1993, Kidney international.

[50]  S. Johnsen.  Testicular biopsy score count--a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males. , 1970, Hormones.

[51]  A. Gornall,et al.  Determination of serum proteins by means of the biuret reaction. , 1949, The Journal of biological chemistry.