Tailored therapy for the refractory GERD patients by combined multichannel intraluminal impedance–pH monitoring

About 30% of patients with gastroesophageal reflux disease (GERD) are refractory to proton pump inhibitor (PPI). The reason for the PPI failure in Asian GERD patients has rarely been studied, and the therapy remained unclear. The aims were to explore the possible reasons for PPI failure and to treat these patients with the guidance of 24‐h multichannel intraluminal impedance‐pH (MII‐pH) monitoring.

[1]  M. Barone,et al.  Tailored therapy guided by multichannel intraluminal impedance pH monitoring for refractory non-erosive reflux disease , 2017, Cell Death & Disease.

[2]  G. Boeckxstaens,et al.  Symptomatic reflux disease: the present, the past and the future , 2014, Gut.

[3]  S. Roman,et al.  Normal values of pharyngeal and esophageal 24-hour pH impedance in individuals on and off therapy and interobserver reproducibility. , 2013, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[4]  D. Sifrim,et al.  Diagnosis and management of patients with reflux symptoms refractory to proton pump inhibitors , 2012, Gut.

[5]  K. Tominaga,et al.  Pathogenesis of proton‐pump inhibitor‐refractory non‐erosive reflux disease according to multichannel intraluminal impedance‐pH monitoring , 2012, Journal of gastroenterology and hepatology.

[6]  G. Boeckxstaens,et al.  Baclofen improves symptoms and reduces postprandial flow events in patients with rumination and supragastric belching. , 2012, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[7]  D. Castell,et al.  Symptoms with acid and nonacid reflux may be produced by different mechanisms. , 2009, Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus.

[8]  R. Fass.  Clinical implications of chronic therapy for GERD. Preface. , 2009, The American journal of gastroenterology.

[9]  D. Castell,et al.  An analysis of persistent symptoms in acid-suppressed patients undergoing impedance-pH monitoring. , 2008, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[10]  A. Meining,et al.  Clinical trial: persistent gastro‐oesophageal reflux symptoms despite standard therapy with proton pump inhibitors – a follow‐up study of intraluminal‐impedance guided therapy , 2007, Alimentary pharmacology & therapeutics.

[11]  S. Roman,et al.  Esophageal pH-Impedance Monitoring and Symptom Analysis in GERD: A Study in Patients off and on Therapy , 2006, The American Journal of Gastroenterology.

[12]  S. Shay,et al.  Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy: a multicentre study using combined ambulatory impedance-pH monitoring , 2006, Gut.

[13]  J. Dent,et al.  Gastro-oesophageal reflux monitoring: review and consensus report on detection and definitions of acid, non-acid, and gas reflux , 2004, Gut.

[14]  D. Castell,et al.  Baclofen decreases acid and non‐acid post‐prandial gastro‐oesophageal reflux measured by combined multichannel intraluminal impedance and pH , 2003, Alimentary pharmacology & therapeutics.

[15]  D. Castell,et al.  Simultaneous intraesophageal impedance and pH measurement of acid and nonacid gastroesophageal reflux: effect of omeprazole. , 2001, Gastroenterology.

[16]  M. Vela,et al.  Clinical Practice Guideline For the Diagnosis and Management of Gastroesophageal Reflux Disease , 2013 .

[17]  M. Numans,et al.  Short-term treatment with proton-pump inhibitors as a test for gastroesophageal reflux disease: a meta-analysis of diagnostic test characteristics. , 2004, Annals of internal medicine.