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The unveiling of the draft sequence of the human genome in 2000 was met with enthusiastic predictions about how genomics would dramatically change the treatment of diseases such as cancer. The years since have brought a 100,000-fold drop in the cost of sequencing a human genome (to just a few thousand US dollars), and the time needed to sequence it has been cut from months to little more than a day. Researchers can therefore now generate unprecedented quantities of data to help in the battle against cancer (see page S20).