Tibetan sound meditation for cognitive dysfunction: results of a randomized controlled pilot trial

Although chemotherapy‐induced cognitive impairment is common among breast cancer patients, evidence for effective interventions addressing cognitive deficits is limited. This randomized controlled trial examined the feasibility and preliminary efficacy of a Tibetan Sound Meditation (TSM) program to improve cognitive function and quality of life in breast cancer patients.

[1]  B. Oh,et al.  Effect of medical Qigong on cognitive function, quality of life, and a biomarker of inflammation in cancer patients: a randomized controlled trial , 2012, Supportive Care in Cancer.

[2]  W. Singer,et al.  Meditation Increases the Depth of Information Processing and Improves the Allocation of Attention in Space , 2012, Front. Hum. Neurosci..

[3]  S. Ersser,et al.  Effectiveness of mindfulness-based stress reduction in mood, breast- and endocrine-related quality of life, and well-being in stage 0 to III breast cancer: a randomized, controlled trial. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[4]  C. Gundy,et al.  Neuropsychological performance in survivors of breast cancer more than 20 years after adjuvant chemotherapy. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[5]  Sanne B. Schagen,et al.  Chemotherapy-Related Cognitive Dysfunction , 2012, Current Neurology and Neuroscience Reports.

[6]  M. Sitskoorn,et al.  Review of recent studies on interventions for cognitive deficits in patients with cancer , 2012, Expert review of anticancer therapy.

[7]  A. Saykin,et al.  Development of CBT for chemotherapy‐related cognitive change: results of a waitlist control trial , 2012, Psycho-oncology.

[8]  Cathy R. Cox,et al.  Tai Chi effects on neuropsychological, emotional, and physical functioning following cancer treatment: a pilot study. , 2012, Complementary therapies in clinical practice.

[9]  C. Lengacher,et al.  Mindfulness based stress reduction in post-treatment breast cancer patients: an examination of symptoms and symptom clusters , 2012, Journal of Behavioral Medicine.

[10]  João Ricardo Sato,et al.  Meditation training increases brain efficiency in an attention task , 2012, NeuroImage.

[11]  J. Armer,et al.  Effects of Mindfulness-Based Stress Reduction (MBSR) on Health Among Breast Cancer Survivors , 2011, Western journal of nursing research.

[12]  M. Irwin,et al.  Inflammation and behavioral symptoms after breast cancer treatment: do fatigue, depression, and sleep disturbance share a common underlying mechanism? , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[13]  D. Veltman,et al.  Cerebral hyporesponsiveness and cognitive impairment 10 years after chemotherapy for breast cancer , 2011, Human brain mapping.

[14]  T. Ahles,et al.  International Cognition and Cancer Task Force recommendations to harmonise studies of cognitive function in patients with cancer. , 2011, The Lancet. Oncology.

[15]  D. Rakel,et al.  Mindfulness in medicine. , 2011, Explore.

[16]  K. Hermelink.  Acute and late onset cognitive dysfunction associated with chemotherapy in women with breast cancer , 2011, Cancer.

[17]  G. McDougall,et al.  Symptom management of affective and cognitive disturbance with a group of cancer survivors. , 2011, Archives of psychiatric nursing.

[18]  H. Dhillon,et al.  The fog hasn’t lifted on “chemobrain” yet: ongoing uncertainty regarding the effects of chemotherapy and breast cancer on cognition , 2010, Breast Cancer Research and Treatment.

[19]  M. El-Tamer,et al.  The cognitive effects of chemotherapy in post-menopausal breast cancer patients: a controlled longitudinal study , 2010, Breast Cancer Research and Treatment.

[20]  T. Morita,et al.  The efficacy of mindfulness-based meditation therapy on anxiety, depression, and spirituality in Japanese patients with cancer. , 2009, Journal of palliative medicine.

[21]  Matthew J. Goodman,et al.  Randomized controlled trial of mindfulness‐based stress reduction (MBSR) for survivors of breast cancer , 2009, Psycho-oncology.

[22]  J. Weis,et al.  Cognitive deficits as long‐term side‐effects of adjuvant therapy in breast cancer patients: ‘subjective’ complaints and ‘objective’ neuropsychological test results , 2009, Psycho-oncology.

[23]  Lorenzo Cohen,et al.  Cancer, cognitive impairment, and meditation , 2009, Acta oncologica.

[24]  D. Shannahoff-Khalsa,et al.  Clinical trials of meditation practices in health care: characteristics and quality. , 2008, Journal of alternative and complementary medicine.

[25]  M. Monje,et al.  Clinical patterns and biological correlates of cognitive dysfunction associated with cancer therapy. , 2008, The oncologist.

[26]  R. Durazo-Arvizu,et al.  Effect of mindfulness based stress reduction on immune function, quality of life and coping in women newly diagnosed with early stage breast cancer , 2008, Brain, Behavior, and Immunity.

[27]  A. Lutz,et al.  Attention regulation and monitoring in meditation , 2008, Trends in Cognitive Sciences.

[28]  L. Sheppard,et al.  Breast Cancer and Sexuality , 2008, The breast journal.

[29]  S. Taillibert,et al.  Chemobrain: is systemic chemotherapy neurotoxic? , 2007, Current opinion in oncology.

[30]  A. Saykin,et al.  Cognitive‐behavioral management of chemotherapy‐related cognitive change , 2007, Psycho-oncology.

[31]  Hillary S. Schaefer,et al.  Neural correlates of attentional expertise in long-term meditation practitioners , 2007, Proceedings of the National Academy of Sciences.

[32]  A. Jha,et al.  Mindfulness training modifies subsystems of attention , 2007, Cognitive, affective & behavioral neuroscience.

[33]  S. Nieuwenhuis,et al.  Mental Training Affects Distribution of Limited Brain Resources , 2007, PLoS biology.

[34]  Andrew J. Saykin,et al.  Candidate mechanisms for chemotherapy-induced cognitive changes , 2007, Nature Reviews Cancer.

[35]  I. Tannock,et al.  Cognitive function, fatigue, and menopausal symptoms in breast cancer patients receiving adjuvant chemotherapy: evaluation with patient interview after formal assessment , 2006, Psycho-oncology.

[36]  C. Meyers,et al.  Chemotherapy and Cognition: Effects, Potential Mechanisms, and Management , 2006, American journal of therapeutics.

[37]  J. Langhinrichsen-Rohling,et al.  A Meta-Analysis of the Neuropsychological Effects of Occupational Exposure to Manganese , 2006, The Clinical neuropsychologist.

[38]  G. Demakis,et al.  A Meta-Analysis of the Neuropsychological Effects of Occupational Exposure to Mercury , 2006, The Clinical neuropsychologist.

[39]  I. Tannock,et al.  Fatigue, menopausal symptoms, and cognitive function in women after adjuvant chemotherapy for breast cancer: 1- and 2-year follow-up of a prospective controlled study. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[40]  A. Lutz,et al.  Long-term meditators self-induce high-amplitude gamma synchrony during mental practice. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[41]  P. Ganz,et al.  Neurocognitive Performance in Breast Cancer Survivors Exposed to Adjuvant Chemotherapy and Tamoxifen , 2004, Journal of clinical and experimental neuropsychology.

[42]  P. Ganz,et al.  Association of breast cancer and its therapy with menopause-related symptoms , 2004, Menopause.

[43]  R. Fouladi,et al.  Psychological adjustment and sleep quality in a randomized trial of the effects of a Tibetan yoga intervention in patients with lymphoma , 2004, Cancer.

[44]  I. Tannock,et al.  Cognitive function, fatigue, and menopausal symptoms in women receiving adjuvant chemotherapy for breast cancer. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[45]  L. Carlson,et al.  Mindfulness‐Based Stress Reduction in Relation to Quality of Life, Mood, Symptoms of Stress, and Immune Parameters in Breast and Prostate Cancer Outpatients , 2003, Psychosomatic medicine.

[46]  R. Davidson,et al.  Alterations in Brain and Immune Function Produced by Mindfulness Meditation , 2003, Psychosomatic medicine.

[47]  D. Cella,et al.  Measuring spiritual well-being in people with cancer: The functional assessment of chronic illness therapy—spiritual well-being scale (FACIT-Sp) , 2002, Annals of behavioral medicine : a publication of the Society of Behavioral Medicine.

[48]  Andrew J Saykin,et al.  Neuropsychologic impact of standard-dose systemic chemotherapy in long-term survivors of breast cancer and lymphoma. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[49]  L. Carlson,et al.  The effects of a mindfulness meditation-based stress reduction program on mood and symptoms of stress in cancer outpatients: 6-month follow-up , 2001, Supportive Care in Cancer.

[50]  L. Carlson,et al.  A Randomized, Wait-List Controlled Clinical Trial: The Effect of a Mindfulness Meditation-Based Stress Reduction Program on Mood and Symptoms of Stress in Cancer Outpatients , 2000, Psychosomatic medicine.

[51]  C. Cleeland,et al.  The rapid assessment of fatigue severity in cancer patients , 1999, Cancer.

[52]  M. Muller,et al.  Cognitive deficits after postoperative adjuvant chemotherapy for breast carcinoma , 1999, Cancer.

[53]  S. Rodenhuis,et al.  Impairment of cognitive function in women receiving adjuvant treatment for high-risk breast cancer: high-dose versus standard-dose chemotherapy. , 1998, Journal of the National Cancer Institute.

[54]  M. Folstein,et al.  Population-based norms for the Mini-Mental State Examination by age and educational level. , 1993, JAMA.

[55]  B. Cimprich,et al.  Development of an intervention to restore attention in cancer patients , 1993, Cancer nursing.

[56]  P. Ganz,et al.  Characteristics of women at risk for psychosocial distress in the year after breast cancer. , 1993, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[57]  P. Lachenbruch.  Statistical Power Analysis for the Behavioral Sciences (2nd ed.) , 1989 .

[58]  Daniel J Buysse,et al.  The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research , 1989, Psychiatry Research.

[59]  J. Fletcher.  Memory for verbal and nonverbal stimuli in learning disability subgroups: analysis by selective reminding. , 1985, Journal of experimental child psychology.

[60]  J. Kabat-Zinn,et al.  An outpatient program in behavioral medicine for chronic pain patients based on the practice of mindfulness meditation: theoretical considerations and preliminary results. , 1982, General hospital psychiatry.

[61]  L. Radloff.  The CES-D Scale , 1977 .

[62]  J. Kwon,et al.  The effect of meditation on brain structure: cortical thickness mapping and diffusion tensor imaging. , 2013, Social cognitive and affective neuroscience.

[63]  K. Kwekkeboom,et al.  Mind-body treatments for the pain-fatigue-sleep disturbance symptom cluster in persons with cancer. , 2010, Journal of pain and symptom management.

[64]  S. Schultz,et al.  Neuropsychological outcomes of older breast cancer survivors: cognitive features ten or more years after chemotherapy. , 2010, The Journal of neuropsychiatry and clinical neurosciences.

[65]  I. Tannock,et al.  Cancer and cancer-therapy related cognitive dysfunction: an international perspective from the Venice cognitive workshop. , 2008, Annals of oncology : official journal of the European Society for Medical Oncology.

[66]  J. Weis,et al.  Rehabilitation of therapy-related cognitive deficits in patients after hematopoietic stem cell transplantation , 2008, Bone Marrow Transplantation.

[67]  F. Cramp,et al.  Exercise for the management of cancer-related fatigue in adults. , 2008, The Cochrane database of systematic reviews.

[68]  A. Lutz,et al.  Attention Regulation and Monitoring in Meditation Review , 2022 .

[69]  P. Jacobsen,et al.  Evaluation of the functional assessment of cancer therapy cognitive scale with hematopoietic stem cell transplant patients. , 2007, Journal of pain and symptom management.

[70]  K. Lange,et al.  Cognitive dysfunction and subjective complaints of cancer patients. a cross-sectional study in a cancer rehabilitation centre. , 2004, European journal of cancer.

[71]  M. Palmer.  Clinical Trials: A Practical Approach , 1985 .