Transfection of CD40 in a human oral squamous cell carcinoma keratinocyte line upregulates immune potency and costimulatory molecules

Background  There is upregulation of class II molecules of the major histocompatibility complex (MHC) by keratinocytes in oral squamous cell carcinoma (OSCC) and inflammatory diseases such as lichen planus. The significance of this expression, or whether it is accompanied by upregulation of membrane‐bound costimulatory molecules, is unknown.

[1]  M. V. Dorrego,et al.  Expresión de las moléculas del Complejo Mayor de Histocompatibilidad clase II y moléculas co-estimuladoras en carcinomas orales in vitro , 2005 .

[2]  W. Boscardin,et al.  Expression and Function of CD28 on Epstein-Barr Virus-Positive B Cell Lines and AIDS-Associated Non-Hodgkin’s Lymphoma Cell Lines , 2003, Tumor Biology.

[3]  S. Khoury,et al.  T cell costimulatory pathways: blockade for autoimmunity , 2003, Expert opinion on biological therapy.

[4]  R. Watson,et al.  Oral mucosal keratinocytes express RANTES and ICAM‐1, but not interleukin‐8, in oral lichen planus and oral lichenoid reactions induced by amalgam fillings , 2003, Clinical and experimental dermatology.

[5]  R. Peach,et al.  In Vivo CD86 Blockade Inhibits CD4+ T Cell Activation, Whereas CD80 Blockade Potentiates CD8+ T Cell Activation and CTL Effector Function1 , 2002, The Journal of Immunology.

[6]  J. Gribben,et al.  CD40 activation of carcinoma cells increases expression of adhesion and major histocompatibility molecules but fails to induce either CD80/CD86 expression or T cell alloreactivity. , 2001, International journal of oncology.

[7]  D. Sheppard,et al.  Expression of the αvβ6 Integrin Promotes Migration and Invasion in Squamous Carcinoma Cells , 2001 .

[8]  F. Fortune,et al.  Expression of adhesion and activation molecules in human buccal epithelial cell lines and normal human buccal epithelium in situ. , 2001, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[9]  N. Park,et al.  Increased ICAM-1 expression in transformed human oral epithelial cells: molecular mechanism and functional role in peripheral blood mononuclear cell adhesion and lymphokine-activated-killer cell cytotoxicity. , 2000, International journal of oncology.

[10]  D. Adams,et al.  CD40 Induces Apoptosis in Carcinoma Cells through Activation of Cytotoxic Ligands of the Tumor Necrosis Factor Superfamily , 2000, Molecular and Cellular Biology.

[11]  P. Vandenabeele,et al.  TTRAP, a Novel Protein That Associates with CD40, Tumor Necrosis Factor (TNF) Receptor-75 and TNF Receptor-associated Factors (TRAFs), and That Inhibits Nuclear Factor-κB Activation* , 2000, The Journal of Biological Chemistry.

[12]  S. Lang,et al.  B7.1 on human carcinomas: costimulation of T cells and enhanced tumor-induced T-cell death. , 2000, Cellular immunology.

[13]  C. Van Waes,et al.  IL‐12‐ and IL‐2‐induced tumor regression in a new murine model of oral squamous‐cell carcinoma is promoted by expression of the CD80 co‐stimulatory molecule and interferon‐γ , 2000, International journal of cancer.

[14]  K. Gulabivala,et al.  The preparation of periapical lesions for flow cytometry. , 2000, International endodontic journal.

[15]  L. Cavacini,et al.  Surface membrane-expressed CD40 is present on tumor cells from squamous cell cancer of the head and neck in vitro and in vivo and regulates cell growth in tumor cell lines. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

[16]  C. Van Waes,et al.  Decreased expression of CD80 is a marker for increased tumorigenicity in a new murine model of oral squamous‐cell carcinoma , 1999, International journal of cancer.

[17]  E. Prens,et al.  Interferon‐γ‐induced ICAM‐1 and CD40 expression, complete lack of HLA‐DR and CD80 (B7.1), and inconsistent HLA‐ABC expression in basal cell carcinoma: a possible role for interleukin‐10? , 1999 .

[18]  L. Vogel,et al.  CD40 and its crucial role as a member of the TNFR family. , 1998, Seminars in immunology.

[19]  J. Grousson.  Functional Relevance of CD40 Expression in Human Epidermis , 1998, Cell Biology and Toxicology.

[20]  D. Schmitt,et al.  Effects of CD40 ligation on human keratinocyte accessory function , 1998, Archives of Dermatological Research.

[21]  A. Gaspari,et al.  Expression of B7-1 by Pam 212 squamous cell carcinoma enhances tumor cell interactions with dendritic epidermal cells but does not affect in vivo tumor growth. , 1997, The Journal of investigative dermatology.

[22]  J. Banchereau,et al.  Functions of CD40 on B cells, dendritic cells and other cells. , 1997, Current opinion in immunology.

[23]  N. Hayashi,et al.  Expression of costimulatory molecules B7‐1 (CD80) and B7‐2 (CD86) on human hepatocellular carcinoma , 1997, Hepatology.

[24]  J. Banchereau,et al.  CD40 ligation of human keratinocytes inhibits their proliferation and induces their differentiation. , 1997, Journal of immunology.

[25]  M. Mori,et al.  The expression of costimulatory molecules CD80 and CD86 in human carcinoma cell lines: its regulation by interferon γ and interleukin-10 , 1996, Cancer Immunology, Immunotherapy.

[26]  E. Clark,et al.  Functional CD40 ligand expressed by human blood dendritic cells is up-regulated by CD40 ligation. , 1996, Journal of immunology.

[27]  R. Flavell,et al.  The Role of CD40 Ligand in Costimulation and T‐Cell Activation , 1996, Immunological reviews.

[28]  H. Otten,et al.  Alloantigen‐specific T‐cell anergy induced by human keratinocytes is abrogated upon loss of cell‐cell contact , 1996, Immunology.

[29]  M. Thornhill,et al.  Cytokine regulation of major histocompatibility complex antigen expression by human oral and skin keratinocytes. , 1996, Archives of oral biology.

[30]  K. Sell,et al.  Induction of Autologous Tumor‐Specific Cytotoxic T‐Lymphocyte Activity Against a Human Renal Carcinoma Cell Line by B7–1 (CD80) Costimulation , 1996, Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy.

[31]  L. Chen,et al.  In vitro priming of tumor-reactive cytolytic T lymphocytes by combining IL-10 with B7-CD28 costimulation. , 1995, Journal of immunology.

[32]  L. Davis,et al.  The CD40 ligand expressed by human B cells costimulates B cell responses. , 1995, Journal of immunology.

[33]  A. Gaspari,et al.  Human keratinocytes regulate their expression of B7/BB-1 antigen by a unique, calcium-dependent mechanism. , 1995, The Journal of investigative dermatology.

[34]  A. Durandy,et al.  Recombinant Soluble Trimeric CD40 Ligand Is Biologically Active * , 1995, The Journal of Biological Chemistry.

[35]  J. Bonnefoy,et al.  CD40 ligand is functionally expressed on human eosinophils , 1995, European journal of immunology.

[36]  L. Glimcher,et al.  Major histocompatibility complex class II+B7-1+ tumor cells are potent vaccines for stimulating tumor rejection in tumor-bearing mice , 1995, The Journal of experimental medicine.

[37]  C. Janeway,et al.  Signals and signs for lymphocyte responses , 1994, Cell.

[38]  B. Shroot,et al.  A novel in vitro model for the study of human keratinocyte/leucocyte interactions under autologous conditions , 1993, The British journal of dermatology.

[39]  C. Elmets,et al.  In situ expression of a B7-like adhesion molecule on keratinocytes from human epidermis. , 1993, The Journal of investigative dermatology.

[40]  S. Kojima,et al.  The Expression of Invasive Behavior of Differentiated Squamous Carcinoma Cell Line Evaluated by an in vitro Invasion Model , 1993, Japanese journal of cancer research : Gann.

[41]  P. Linsley,et al.  Phorbol-12-myristate-13-acetate-treated human keratinocytes express B7-like molecules that serve a costimulatory role in T-cell activation. , 1993, The Journal of investigative dermatology.

[42]  P. Farthing,et al.  Langerhans cell distribution and keratinocyte expression of HLADR in oral lichen planus. , 1992, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[43]  S. Rice,et al.  Production of a Suppressor of Lymphocyte Proliferation by Two Human Oral Carcinoma Cell Lines , 1992, Scandinavian journal of immunology.

[44]  C. Scully,et al.  MHC antigen expression in human oral squamous carcinoma cell lines , 1991, The Journal of pathology.

[45]  C. Scully,et al.  Effect of IFN–γon the expression of MHC class I and class II antigens in a human malignant oral epithelial cell line , 1991 .

[46]  P. Farthing,et al.  Expression of MHC class II antigens (HLA DR, DP and DQ) by keratinocytes in oral lichen planus. , 1989, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[47]  S. Rice,et al.  The expression of MHC antigens on cultured oral keratinocytes and relationship to malignancy. , 1988, British journal of experimental pathology.

[48]  N. Savage,et al.  Expression of class I and class II major histocompatibility complex antigens on oral mucosal epithelium. , 1987, Journal of oral pathology.

[49]  T. Luger,et al.  Human Epidermal Cells Synthesize HLA-DR Alloantigens In Vitro upon Stimulation with γ-Interferon , 1985 .

[50]  T. Merigan,et al.  Recombinant gamma interferon induces HLA-DR expression on cultured human keratinocytes. , 1984, The Journal of investigative dermatology.

[51]  R. Jonsson,et al.  Maintained CD40 and loss of polarised CD40 ligand expression in oral squamous cell carcinoma. , 2001, Anticancer research.

[52]  I. Fernández,et al.  Expression of intercellular adhesion molecule 1 (ICAM-1) in oral squamous cell carcinoma. , 2000, Medicina oral : organo oficial de la Sociedad Espanola de Medicina Oral y de la Academia Iberoamericana de Patologia y Medicina Bucal.

[53]  B. Wollenberg,et al.  Impairment of T-cell activation in head and neck cancer in situ and in vitro: strategies for an immune restoration. , 1999, Archives of otolaryngology--head & neck surgery.

[54]  R. Flavell,et al.  CD40 and CD154 in cell-mediated immunity. , 1998, Annual review of immunology.

[55]  D. Schmitt,et al.  CD40 expression in epidermal tumors. , 1997, Anticancer research.

[56]  J. B. Matthews,et al.  Inflammatory cell infiltrate associated with primary and transplanted tumours in an inbred model of oral carcinogenesis. , 1995, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[57]  C. Scully,et al.  Effect of IFN-gamma on the expression of MHC class I and class II antigens in a human malignant oral epithelial cell line. , 1991, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[58]  T. Merigan,et al.  Recombinant gamma interferon differentially regulates class II antigen expression and biosynthesis on cultured normal human keratinocytes. , 1985, Journal of interferon research.

[59]  T. Luger,et al.  Human epidermal cells synthesize HLA-DR alloantigens in vitro upon stimulation with gamma-interferon. , 1985, The Journal of investigative dermatology.