Microfluidic design of complex emulsions.

Controllable generation of complex emulsions comprising exceptional features such as several compartments and shape anisotropy is becoming increasingly important. Complex emulsions are attracting great interest due to their significant potential in many applications, including foods, pharmaceuticals, cosmetics, materials, and chemical separations. Microfluidics is emerging as a promising route to the generation of complex emulsions, providing precise control over emulsion shape, size, and compartments. The aim of this Minireview is to mainly describe the progress of microfluidic approaches to design complex emulsions using hydrodynamic control and phase separation. The emulsions formed are classified according to their morphology, anisotropy, and internal structure. Emerging applications of complex emulsions formed using these microfluidic techniques are discussed.

[1]  A. Abate,et al.  High-order multiple emulsions formed in poly(dimethylsiloxane) microfluidics. , 2009, Small.

[2]  D. Weitz,et al.  Dripping, Jetting, Drops, and Wetting: The Magic of Microfluidics , 2007 .

[3]  J. Bibette,et al.  Shear Rupturing of Complex Fluids: Application to the Preparation of Quasi-Monodisperse Water-in-Oil-in-Water Double Emulsions , 2001 .

[4]  Cherng-Yuan Lin,et al.  Emulsification characteristics of three- and two-phase emulsions prepared by the ultrasonic emulsification method , 2006 .

[5]  Jae-Min Jeong,et al.  Microfluidic synthesis of anisotropic particles from Janus drop by in situ photopolymerization , 2012 .

[6]  Zhibing Hu,et al.  Fabrication of monodisperse gel shells and functional microgels in microfluidic devices. , 2007, Angewandte Chemie.

[7]  G. Whitesides,et al.  Soft lithographic methods for nano-fabrication , 1997 .

[8]  Jian Zhang,et al.  Polymerization optimization of SU-8 photoresist and its applications in microfluidic systems and MEMS , 2001 .

[9]  Jin Woong Kim,et al.  Multiple polymersomes for programmed release of multiple components. , 2011, Journal of the American Chemical Society.

[10]  A. Abate,et al.  Microfluidic Assembly of Magnetic Hydrogel Particles with Uniformly Anisotropic Structure , 2009 .

[11]  M. Kreutzer,et al.  Monodisperse hydrogel microspheres by forced droplet formation in aqueous two-phase systems. , 2011, Lab on a chip.

[12]  Toshiro Higuchi,et al.  Novel microreactors for functional polymer beads , 2004 .

[13]  D. Weitz,et al.  Microfluidic fabrication of monodisperse biocompatible and biodegradable polymersomes with controlled permeability. , 2008, Journal of the American Chemical Society.

[14]  Liang-Yin Chu,et al.  Controllable monodisperse multiple emulsions. , 2007, Angewandte Chemie.

[15]  Baoguo Wang,et al.  Fabrication of monodisperse toroidal particles by polymer solidification in microfluidics. , 2009, Chemphyschem : a European journal of chemical physics and physical chemistry.

[16]  G. Ma,et al.  Preparation of uniform-sized polystyrene-polyacrylamide composite microspheres from a W/O/W emulsion by membrane emulsification technique and subsequent suspension polymerization , 2004 .

[17]  Wei Wang,et al.  A novel thermo-induced self-bursting microcapsule with magnetic-targeting property. , 2009, Chemphyschem : a European journal of chemical physics and physical chemistry.

[18]  P. Umbanhowar,et al.  Monodisperse Emulsion Generation via Drop Break Off in a Coflowing Stream , 2000 .

[19]  D. Weitz,et al.  Dripping to jetting transitions in coflowing liquid streams. , 2007, Physical review letters.

[20]  Y. Mine,et al.  Preparation and stabilization of simple and multiple emulsions using a microporous glass membrane , 1996 .

[21]  G. Whitesides,et al.  Components for integrated poly(dimethylsiloxane) microfluidic systems , 2002, Electrophoresis.

[22]  D. C. Mukherjee,et al.  Liquid membrane multiple emulsion process of separation of copper(II) from waste waters , 2000 .

[23]  E. Kamio,et al.  Monodisperse water-in-water-in-oil emulsion droplets. , 2011, Chemphyschem : a European journal of chemical physics and physical chemistry.

[24]  D. Weitz,et al.  Amphiphilic crescent-moon-shaped microparticles formed by selective adsorption of colloids. , 2011, Journal of the American Chemical Society.

[25]  S. Sugiura,et al.  Preparation characteristics of water-in-oil-in-water multiple emulsions using microchannel emulsification. , 2004, Journal of colloid and interface science.

[26]  André R Studart,et al.  Droplet microfluidics for fabrication of non-spherical particles. , 2010, Macromolecular rapid communications.

[27]  Gerald Muschiolik,et al.  Multiple emulsions for food use , 2007 .

[28]  Mitsutoshi Nakajima,et al.  Preparation of monodisperse water-in-oil-in-water emulsions using microfluidization and straight-through microchannel emulsification , 2005 .

[29]  R. Boom,et al.  Preparation of double emulsions by membrane emulsification—a review , 2005 .

[30]  I. M. Walker,et al.  [5] Multiple emulsions as targetable delivery systems , 1987 .

[31]  H. Stone,et al.  Formation of dispersions using “flow focusing” in microchannels , 2003 .

[32]  Chang-Soo Lee,et al.  Regioselective surface modification of pdms microfluidic device for the generation of monodisperse double emulsions , 2012, Macromolecular Research.

[33]  Yuanjin Zhao,et al.  Biodegradable core-shell carriers for simultaneous encapsulation of synergistic actives. , 2013, Journal of the American Chemical Society.

[34]  A. Gañán-Calvo,et al.  Perfectly monodisperse microbubbling by capillary flow focusing. , 2001, Physical review letters.

[35]  M. Blanco-Prieto,et al.  Multiple emulsion technology for the design of microspheres containing peptides and oligopeptides. , 1997, Advanced drug delivery reviews.

[36]  Michiel T. Kreutzer,et al.  All-aqueous core-shell droplets produced in a microfluidic device , 2011 .

[37]  David A Weitz,et al.  One-step emulsification of multiple concentric shells with capillary microfluidic devices. , 2011, Angewandte Chemie.

[38]  M. Nakano Places of emulsions in drug delivery. , 2000, Advanced drug delivery reviews.

[39]  Ho Cheung Shum,et al.  Multicompartment polymersomes from double emulsions. , 2011, Angewandte Chemie.

[40]  Rustem F Ismagilov,et al.  Formation of droplets of alternating composition in microfluidic channels and applications to indexing of concentrations in droplet-based assays. , 2004, Analytical chemistry.

[41]  Xiaohu Gao,et al.  Multifunctional nanocapsules for simultaneous encapsulation of hydrophilic and hydrophobic compounds and on-demand release. , 2012, ACS nano.

[42]  Do Hyun Kim,et al.  Droplet-based microextraction in the aqueous two-phase system. , 2010, Journal of chromatography. A.

[43]  G. Whitesides,et al.  Generation of monodisperse particles by using microfluidics: control over size, shape, and composition. , 2005, Angewandte Chemie.

[44]  T. Uchida,et al.  Preparation and characterization of polylactic acid microspheres containing water-soluble dyes using a novel w/o/w emulsion solvent evaporation method. , 1996, Journal of microencapsulation.

[45]  Chun-Xia Zhao,et al.  Microfluidic mass-transfer control for the simple formation of complex multiple emulsions. , 2009, Angewandte Chemie.

[46]  S. Friberg,et al.  A one-step process to a Janus emulsion. , 2011, Journal of colloid and interface science.

[47]  G. Vladisavljević,et al.  Influence of process parameters on droplet size distribution in SPG membrane emulsification and stability of prepared emulsion droplets , 2003 .

[48]  S. Friberg,et al.  One-step inversion process to a Janus emulsion with two mutually insoluble oils. , 2011, Langmuir : the ACS journal of surfaces and colloids.

[49]  Sebastián Chávez,et al.  Flow Focusing: a versatile technology to produce size-controlled and specific-morphology microparticles. , 2005, Small.

[50]  Minseok Seo,et al.  Polymer particles with various shapes and morphologies produced in continuous microfluidic reactors. , 2005, Journal of the American Chemical Society.

[51]  Y. Rhee,et al.  Generation of monodisperse alginate microbeads and in situ encapsulation of cell in microfluidic device , 2007, Biomedical microdevices.

[52]  Sebastian Seiffert,et al.  Microgel capsules tailored by droplet-based microfluidics. , 2013, Chemphyschem : a European journal of chemical physics and physical chemistry.

[53]  R. Ismagilov,et al.  Effects of viscosity on droplet formation and mixing in microfluidic channels , 2004 .

[54]  David A. Weitz,et al.  Single step emulsification for the generation of multi-component double emulsions , 2012 .

[55]  David A. Weitz,et al.  Controlled fabrication of polymer microgels by polymer-analogous gelation in droplet microfluidics , 2010 .

[56]  Daeyeon Lee,et al.  Double emulsion templated monodisperse phospholipid vesicles. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[57]  Yang Song,et al.  Monodisperse w/w/w double emulsion induced by phase separation. , 2012, Langmuir : the ACS journal of surfaces and colloids.

[58]  Chang-Soo Lee,et al.  One Step Formation of Controllable Complex Emulsions: From Functional Particles to Simultaneous Encapsulation of Hydrophilic and Hydrophobic Agents into Desired Position , 2013, Advanced materials.

[59]  G. Hardee,et al.  Improvement of the encapsulation efficiency of oligonucleotide-containing biodegradable microspheres. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[60]  A. Abate,et al.  One-step formation of multiple emulsions in microfluidics. , 2011, Lab on a chip.

[61]  T. Hwang,et al.  In situ microfluidic synthesis of monodisperse PEG microspheres , 2009 .

[62]  S. Quake,et al.  Dynamic pattern formation in a vesicle-generating microfluidic device. , 2001, Physical review letters.

[63]  Jae-Hoon Jung,et al.  Novel one-pot route to monodisperse thermosensitive hollow microcapsules in a microfluidic system. , 2008, Lab on a chip.

[64]  Toru Torii,et al.  Formation of Biphasic Janus Droplets in a Microfabricated Channel for the Synthesis of Shape‐Controlled Polymer Microparticles , 2007 .

[65]  Chang-Soo Lee,et al.  Microfluidic Preparation of Monodisperse Multiple Emulsion using Hydrodynamic Control , 2012 .

[66]  Toru Torii,et al.  Controlled production of monodisperse double emulsions by two-step droplet breakup in microfluidic devices. , 2004, Langmuir : the ACS journal of surfaces and colloids.

[67]  Annie Colin,et al.  Mastering a double emulsion in a simple co-flow microfluidic to generate complex polymersomes. , 2011, Langmuir : the ACS journal of surfaces and colloids.

[68]  Andrew J. deMello,et al.  Rapid cell extraction in aqueous two-phase microdroplet systems , 2010 .

[69]  G. Luo,et al.  Shear force induced monodisperse droplet formation in a microfluidic device by controlling wetting properties. , 2006, Lab on a chip.

[70]  Young-Soo Song,et al.  Microextraction in a tetrabutylammonium bromide/ammonium sulfate aqueous two-phase system and electrohydrodynamic generation of a micro-droplet. , 2007, Journal of chromatography. A.

[71]  Ho Cheung Shum,et al.  Dewetting-induced membrane formation by adhesion of amphiphile-laden interfaces. , 2011, Journal of the American Chemical Society.

[72]  M. Márquez,et al.  Monodisperse structured multi-vesicle microencapsulation using flow-focusing and controlled disturbance , 2005, Journal of microencapsulation.

[73]  Erich J. Windhab,et al.  Drop formation in a co-flowing ambient fluid , 2004 .

[74]  Takeshi Hatsuzawa,et al.  A microfluidic cross-flowing emulsion generator for producing biphasic droplets and anisotropically shaped polymer particles , 2010 .

[75]  G. Whitesides,et al.  Soft lithography in biology and biochemistry. , 2001, Annual review of biomedical engineering.

[76]  George M. Whitesides,et al.  Erratum: Formation of droplets and bubbles in a microfluidic T-junction - Scaling and mechanism of break-up (Lab on a Chip-Miniaturisation for Chemistry and Biology (2006) 6 (437) DOI: 10.1039/b510841a) , 2006 .

[77]  D. Weitz,et al.  Monodisperse Double Emulsions Generated from a Microcapillary Device , 2005, Science.