Novel two step synthesis of pyrazoles and isoxazoles from aryl methyl ketones
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Various acetyl aromatics when reacted with dimethylformamide dimethyl acetal gave 1-aryl-3-dimethylamino-2-propen-1-ones. These intermediates are masked β-ketoaldehydes and react with hydrazine hydrate or hydroxylamine at room temperature to give in good yields pyrazoles or isoxazoles.
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