Synthesis of novel 5-[(1,2,3-triazol-4-yl)methyl]-1-methyl-3H-pyridazino[4,5-b]indol-4-one derivatives by click reaction and exploration of their anticancer activity

[1]  Lata,et al.  Design and synthesis of novel 2H-chromen-2-one derivatives bearing 1,2,3-triazole moiety as lead antimicrobials. , 2014, Bioorganic & medicinal chemistry letters.

[2]  P. Yogeeswari,et al.  Rational design and synthesis of novel dibenzo[b,d]furan-1,2,3-triazole conjugates as potent inhibitors of Mycobacterium tuberculosis. , 2014, European journal of medicinal chemistry.

[3]  P. Yogeeswari,et al.  Rational design, synthesis and antitubercular evaluation of novel 2-(trifluoromethyl)phenothiazine-[1,2,3]triazole hybrids. , 2014, Bioorganic & medicinal chemistry letters.

[4]  A. V. Adhikari,et al.  Facile synthesis of new imidazo[1,2-a]pyridines carrying 1,2,3-triazoles via click chemistry and their antiepileptic studies. , 2013, Bioorganic & medicinal chemistry letters.

[5]  Dariusz Matosiuk,et al.  Click chemistry for drug development and diverse chemical-biology applications. , 2013, Chemical reviews.

[6]  L. Meijer,et al.  Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indoles as PI3Kα inhibitors. , 2012, European journal of medicinal chemistry.

[7]  P. Yogeeswari,et al.  Design, synthesis, and structure-activity correlations of novel dibenzo[b,d]furan, dibenzo[b,d]thiophene, and N-methylcarbazole clubbed 1,2,3-triazoles as potent inhibitors of Mycobacterium tuberculosis. , 2012, Journal of medicinal chemistry.

[8]  Reddanna Pallu,et al.  Synthesis of novel 2-mercapto benzothiazole and 1,2,3-triazole based bis-heterocycles: their anti-inflammatory and anti-nociceptive activities. , 2012, European journal of medicinal chemistry.

[9]  M. Botta,et al.  Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1. , 2012, Bioorganic & medicinal chemistry.

[10]  V. Pore,et al.  Click chemistry: 1,2,3-triazoles as pharmacophores. , 2011, Chemistry, an Asian journal.

[11]  Jerzy Wegiel,et al.  Harmine is an ATP-competitive inhibitor for dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A). , 2011, Archives of biochemistry and biophysics.

[12]  Nobutoshi Ito,et al.  Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A. , 2010, Nature communications.

[13]  A. Mueller,et al.  Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry. , 2009, Bioorganic & medicinal chemistry letters.

[14]  Jeffrey T. Kuethe,et al.  Practical methodologies for the synthesis of indoles. , 2006, Chemical reviews.

[15]  G. Tron,et al.  Rapid synthesis of triazole-modified resveratrol analogues via click chemistry. , 2006, Journal of medicinal chemistry.

[16]  P. Efron,et al.  Inhibition of the PI3K/AKT pathway enhances trail induced apoptosis in neuroblastoma cells , 2003 .

[17]  Roger L. Williams,et al.  Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. , 2000, Molecular cell.

[18]  J. Lasarte,et al.  Indoles and pyridazino[4,5-b]indoles as nonnucleoside analog inhibitors of HIV-1 reverse transcriptase , 1995 .

[19]  Richard A. Jones,et al.  Potentially Tautomeric 1,2,3,4-Tetrahydro-1,4-dioxo-5H-pyridazino(4,5- b)indole. , 1994 .

[20]  R. Jones,et al.  Potentially tautomeric 1,2,3,4-tetrahydro-1,4-dioxo-5H-pyridazino[4,5-bindole , 1993 .

[21]  A. Monge,et al.  New 5H-pyridazino[4,5-b]indole derivatives. Synthesis and studies as inhibitors of blood platelet aggregation and inotropics. , 1991, Journal of medicinal chemistry.

[22]  A. Monge,et al.  1-Hydrazino-4-(3,5-dimethyl-1-pyrazolyl)-5H-pyridazino[4,5-b]indole. A new antihypertensive agent , 1991 .

[23]  P. Nantka-Namirski,et al.  2-Carbethoxyindole derivatives. I. Synthesis of 8-alkoxy- and 8,9-benzo-3H-pyridazino(4,5-b) indol-4-ones. , 1972, Acta poloniae pharmaceutica.