THE ROLE OF HAEM IN THE ACTIVITY OF CHLOROQUINE AND RELATED ANTIMALARIAL DRUGS
暂无分享,去创建一个
[1] T. Egan,et al. Characterisation of synthetic beta-haematin and effects of the antimalarial drugs quinidine, halofantrine, desbutylhalofantrine and mefloquine on its formation. , 1999, Journal of inorganic biochemistry.
[2] P. Sadler,et al. ELECTRON-TRANSFER-DRIVEN TRANS-LIGAND LABILIZATION : A NOVEL ACTIVATION MECHANISM FOR PT(IV) ANTICANCER COMPLEXES , 1998 .
[3] D. S. Bohle,et al. Aggregated Heme Detoxification Byproducts in Malarial Trophozoites: β-Hematin and Malaria Pigment Have a Single S = 5/2 Iron Environment in the Bulk Phase as Determined by EPR and Magnetic Mössbauer Spectroscopy , 1998 .
[4] D. Taramelli,et al. A microtitre-based method for measuring the haem polymerization inhibitory activity (HPIA) of antimalarial drugs. , 1998, The Journal of antimicrobial chemotherapy.
[5] H. Matile,et al. A comparison and analysis of several ways to promote haematin (haem) polymerisation and an assessment of its initiation in vitro. , 1998, Biochemical pharmacology.
[6] H. Matile,et al. An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials. , 1998, Biochemical pharmacology.
[7] Virander S. Chauhan,et al. Synthetic peptides corresponding to a repetitive sequence of malarial histidine rich protein bind haem and inhibit haemozoin formation in vitro. , 1997, Molecular and biochemical parasitology.
[8] T. Egan,et al. Thermodynamic factors controlling the interaction of quinoline antimalarial drugs with ferriprotoporphyrin IX. , 1997, Journal of inorganic biochemistry.
[9] D. Taramelli,et al. Non‐iron porphyrins inhibit β‐haematin (malaria pigment) polymerisation , 1997 .
[10] H. Bächinger,et al. Xanthones as antimalarial agents; studies of a possible mode of action , 1997, FEBS letters.
[11] G. Blauer,et al. Investigations of B- and β-hematin , 1997 .
[12] D. Wirth,et al. New Targets for Antimalarial Drug Discovery , 1997 .
[13] B. K. Park,et al. Synthesis, antimalarial activity, and molecular modeling of tebuquine analogues. , 1997, Journal of medicinal chemistry.
[14] R. Dinnebier,et al. Characterization of the Products of the Heme Detoxification Pathway in Malarial Late Trophozoites by X-ray Diffraction* , 1997, The Journal of Biological Chemistry.
[15] D. Goldberg,et al. Structure of a novel antimalarial gallium(III) complex with selective activity against chloroquine-resistant Plasmodium falciparum , 1997 .
[16] P. Rosenthal,et al. Hemoglobin catabolism and iron utilization by malaria parasites. , 1996, Molecular and biochemical parasitology.
[17] D. Krogstad,et al. Aminoquinolines that circumvent resistance in Plasmodium falciparum in vitro. , 1996, The American journal of tropical medicine and hygiene.
[18] A. Chou,et al. Heat-labile and heat-stimulable heme polymerase activities in Plasmodium berghei. , 1996, Molecular and biochemical parasitology.
[19] D. Sullivan,et al. On the molecular mechanism of chloroquine's antimalarial action. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[20] T. Egan,et al. The interaction of the heme-octapeptide, N-acetylmicroperoxidase-8 with antimalarial drugs: solution studies and modeling by molecular mechanics methods. , 1996, Journal of inorganic biochemistry.
[21] B. Tekwani,et al. Formation of haemozoin/β‐haematin under physiological conditions is not spontaneous , 1996, FEBS letters.
[22] T. Egan,et al. The chemical mechanism of beta-haematin formation studied by Mössbauer spectroscopy. , 1996, The Biochemical journal.
[23] R. Ridley,et al. Haemozoin formation in malaria parasites: is there a haem polymerase? , 1996, Trends in microbiology.
[24] T. Egan,et al. The iron environment in heme and heme-antimalarial complexes of pharmacological interest. , 1996, Journal of inorganic biochemistry.
[25] D. Sullivan,et al. Plasmodium Hemozoin Formation Mediated by Histidine-Rich Proteins , 1996, Science.
[26] T. Egan,et al. THE MECHANISM OF ACTION OF QUINOLINES AND RELATED ANTI-MALARIAL DRUGS , 1996 .
[27] B. Berger,et al. Haem polymerization in malaria , 1995, Nature.
[28] M. Kansy,et al. Haem polymerization in malaria , 1995, Nature.
[29] D. Warhurst. Haemozoin and the mode of action of blood schizontocides: more controversy. , 1995, Parasitology today.
[30] H. Matile,et al. Malarial haemozoin/β-haematin supports haem polymerization in the absence of protein , 1995, Nature.
[31] T. Egan,et al. Quinoline anti‐malarial drugs inhibit spontaneous formation of β‐haematin (malaria pigment) , 1994 .
[32] F. King. Medicinal chemistry : principles and practice , 1994 .
[33] E. Bauminger,et al. Further evidence for the interaction of the antimalarial drug amodiaquine with ferriprotoporphyrin IX. , 1993, Biochemical pharmacology.
[34] Z. Malik,et al. The antibacterial activity of haemin compared with cobalt, zinc and magnesium protoporphyrin and its effect on potassium loss and ultrastructure of Staphylococcus aureus. , 1993, FEMS microbiology letters.
[35] A. Chou,et al. Control of heme polymerase by chloroquine and other quinoline derivatives. , 1993, Biochemical and biophysical research communications.
[36] D. S. Bohle,et al. Synthesis of β-hematin by dehydrohalogenation of hemin , 1993 .
[37] G. Luzzi,et al. Adverse Effects of Antimalarials , 1993, Drug safety.
[38] A F Slater,et al. Chloroquine: mechanism of drug action and resistance in Plasmodium falciparum. , 1993, Pharmacology & therapeutics.
[39] H. Maeda,et al. Bactericidal activity of alkyl peroxyl radicals generated by heme-iron-catalyzed decomposition of organic peroxides. , 1992, Archives of biochemistry and biophysics.
[40] H. Ginsburg,et al. Quinoline-containing antimalarials--mode of action, drug resistance and its reversal. An update with unresolved puzzles. , 1992, Biochemical pharmacology.
[41] A. Cerami,et al. Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites , 1992, Nature.
[42] A. Chou,et al. Heme polymerase: modulation by chloroquine treatment of a rodent malaria. , 1992, Life sciences.
[43] G. Padmanaban,et al. Chloroquine inhibits heme-dependent protein synthesis in Plasmodium falciparum. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[44] M. Suzuki,et al. The chemical basis for the ferriprotoporphyrin IX-chloroquine complex induced lipid peroxidation. , 1991, Biochimica et biophysica acta.
[45] E. Veignie,et al. The mode of action of chloroquine. Non-weak base properties of 4-aminoquinolines and antimalarial effects on strains of Plasmodium. , 1991, Annals of tropical medicine and parasitology.
[46] D. Goldberg,et al. An iron-carboxylate bond links the heme units of malaria pigment. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[47] J. Oppenheim,et al. Biochemical characterization of Plasmodium falciparum hemozoin. , 1990, The American journal of tropical medicine and hygiene.
[48] D. Goldberg,et al. Hemoglobin degradation in the malaria parasite Plasmodium falciparum: an ordered process in a unique organelle. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[49] D. Goldberg. Hemoglobin degradation in the malaria parasite : an ordered process in a unique organelle , 1990 .
[50] J. Phillipson,et al. In vitro studies on the mode of action of quassinoids with activity against chloroquine-resistant Plasmodium falciparum. , 1989, Biochemical pharmacology.
[51] H. Ginsburg,et al. Alkalinization of the food vacuole of malaria parasites by quinoline drugs and alkylamines is not correlated with their antimalarial activity. , 1989, Biochemical pharmacology.
[52] W. Wernsdorfer,et al. Malaria: Principles and Practice of Malariology , 1989 .
[53] D. Warhurst,et al. The composition of haemozoin from Plasmodium falciparum. , 1989, Transactions of the Royal Society of Tropical Medicine and Hygiene.
[54] P. Schlesinger,et al. Antimalarial agents: mechanisms of action , 1988, Antimicrobial Agents and Chemotherapy.
[55] H. Ginsburg,et al. Effects of quinoline-containing antimalarials on the erythrocyte membrane and their significance to drug action on Plasmodium falciparum. , 1988, Biochemical pharmacology.
[56] I. Constantinidis,et al. UV-visible and carbon NMR studies of chloroquine binding to urohemin I chloride and uroporphyrin I in aqueous solutions , 1988 .
[57] C. D. Fitch,et al. The state of ferriprotoporphyrin IX in malaria pigment. , 1987, The Journal of biological chemistry.
[58] M. Nakano,et al. A ferriprotoporphyrin IX‐chloroquine complex promotes membrane phospholipid peroxidation A possible mechanism for antimalarial action , 1987, FEBS letters.
[59] D. V. Vander Jagt,et al. Comparison of proteases from chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum. , 1987, Biochemical pharmacology.
[60] H. Ginsburg,et al. Current concepts and new ideas on the mechanism of action of quinoline-containing antimalarials. , 1987, Biochemical pharmacology.
[61] P. Schlesinger,et al. The basis of antimalarial action: non-weak base effects of chloroquine on acid vesicle pH. , 1987, The American journal of tropical medicine and hygiene.
[62] D. Warhurst. Antimalarial interaction with ferriprotoporphyrin IX monomer and its relationship to activity of the blood schizontocides. , 1987, Annals of tropical medicine and parasitology.
[63] G. Blauer. Optical properties of complexes of antimalarial drugs with ferriprotoporphyrin IX in aqueous medium. I. The system ferriprotoporphyrin IX-quinine. , 1986, Archives of biochemistry and biophysics.
[64] G. Prensier,et al. Affinity of antimalarial drugs for stacked haematin linked on sepharose. , 1986, Annals of tropical medicine and parasitology.
[65] D. V. Vander Jagt,et al. Characterization of a hemoglobin-degrading, low molecular weight protease from Plasmodium falciparum. , 1986, Molecular and biochemical parasitology.
[66] I. Gluzman,et al. Antimalarials increase vesicle pH in Plasmodium falciparum , 1985, The Journal of cell biology.
[67] B. Perly,et al. A nuclear magnetic resonance study of the interactions of antimalarial drugs with porphyrins. , 1985, Biochimica et biophysica acta.
[68] H. Ginsburg,et al. Susceptibility of human malaria parasites to chloroquine is pH dependent. , 1985, Proceedings of the National Academy of Sciences of the United States of America.
[69] J. Shelnutt. Metal effects on metalloporphyrins and on their .pi.-.pi. charge-transfer complexes with aromatic acceptors: urohemin complexes , 1983 .
[70] I. Sherman,et al. Purification of Plasmodium lophurae cathepsin D and its effects on erythrocyte membrane proteins. , 1983, Molecular and biochemical parasitology.
[71] J. Shelnutt. Correlation between metal stability, charge transfer, and Raman frequencies in metalloporphyrins and their π-π complexes , 1983 .
[72] J. Shelnutt. Molecular complexes of copper uroporphyrin with aromatic acceptors , 1983 .
[73] S. Moreau,et al. Interactions de la chloroquine avec la ferriprotoporphyrine IX: Étude par résonance magnétique nucléaire , 1982 .
[74] M. Pfaller,et al. Lysis of Plasmodium falciparum by ferriprotoporphyrin IX and a chloroquine-ferriprotoporphyrin IX complex , 1982, Antimicrobial Agents and Chemotherapy.
[75] W. Trager,et al. Peptidases from Plasmodium falciparum cultured in vitro. , 1982, Molecular and biochemical parasitology.
[76] D. Warhurst,et al. The quinine-haemin interaction and its relationship to antimalarial activity. , 1981, Biochemical pharmacology.
[77] C. D. Fitch,et al. Hemin lyses malaria parasites. , 1981, Science.
[78] A. Chou,et al. Mechanism of hemolysis induced by ferriprotoporphyrin IX. , 1981, The Journal of clinical investigation.
[79] J. Shelnutt. Structure of molecular complexes of copper uroporphyrin with aromatic heterocycles , 1981 .
[80] A. Chou,et al. Ferriprotoporphyrin IX fulfills the criteria for identification as the chloroquine receptor of malaria parasites. , 1980, Biochemistry.
[81] W. Wilson,et al. Molecular structural effects involved in the interaction of quinolinemethanolamines with DNA. Implications for antimalarial action. , 1977, Journal of medicinal chemistry.
[82] W. Wilson,et al. Mefloquine, a clinically useful quinolinemethanol antimalarial which does not significantly bind to DNA , 1975, Nature.
[83] W. Caughey,et al. Magnetic and spectroscopic probes for FeOFe linkages in hemin systems. , 1975, Bioinorganic chemistry.
[84] J. Simplicio. Hemin monomers in micellar sodium lauryl sulfate. A spectral and equilibrium study with cyanide. , 1972, Biochemistry.
[85] D. Warhurst,et al. Lysosomes, pH and the Anti-malarial Action of Chloroquine , 1972, Nature.
[86] R. Howells,et al. Modifications of the respiratory enzymes associated with chloroquine resistance in P. berghei. , 1971, Transactions of the Royal Society of Tropical Medicine and Hygiene.
[87] D. Warhurst,et al. A physico-chemical explanation for the clumping of malaria pigment by chloroquine. , 1971, Transactions of the Royal Society of Tropical Medicine and Hygiene.
[88] K. Van Dyke,et al. Quinacrine: Mechanisms of Antimalarial Action , 1970, Science.
[89] W. Caughey,et al. Substituted deuteroporphyrins. VI. Ligand-exchange and dimerization reactions of deuterohemins. , 1969, Biochemistry.
[90] P. K. Hepler,et al. THE FEEDING MECHANISM OF AVIAN MALARIAL PARASITES , 1966, The Journal of cell biology.
[91] F. E. Hahn,et al. Chloroquine: Mode of Action , 1966, Science.
[92] W. Trager,et al. Pinocytotic uptake and the digestion of hemoglobin in malaria parasites. , 1965, The Journal of protozoology.
[93] S. Cohen,et al. Inhibition of DNA and RNA polymerase reactions by chloroquine. , 1965, Proceedings of the National Academy of Sciences of the United States of America.
[94] H. Zalkin,et al. Lipide peroxidation in isolated mitochondria , 1959 .
[95] Parker Fs,et al. The interaction of chloroquine with nucleic acids and nucleoproteins. , 1952 .
[96] Cowgill Rw,et al. Metalloporphyrins. VII. Coordination of imidazoles with ferrimesoporphyrin. , 1952 .
[97] J. Legge,et al. Hematin compounds and bile pigments , 1949 .
[98] T. Davies. METALLOPORPHYRINS III. COORDINATION OF NITROGENOUS BASES WITH IRON MESO-, PROTO-, AND HEMATOPORPHYRINS , 1940 .
[99] W. Brown,et al. MALARIAL PIGMENT (SO-CALLED MELANIN): ITS NATURE AND MODE OF PRODUCTION , 1911, The Journal of experimental medicine.