Replication confers β cell immaturity
暂无分享,去创建一个
H. Bengtsson | A. F. Stewart | D. Scott | M. Hebrok | R. Roy | Nilotpal Roy | H. Russ | Sapna Puri | Laura Leonhardt | E. K. French
[1] J. Henquin,et al. Immaturity of insulin secretion by pancreatic islets isolated from one human neonate , 2017, Journal of diabetes investigation.
[2] M. Hebrok,et al. All mixed up: defining roles for β-cell subtypes in mature islets. , 2017, Genes & development.
[3] Howard Y. Chang,et al. Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function. , 2016, Cell metabolism.
[4] S. Itzkovitz,et al. The Genetic Program of Pancreatic β-Cell Replication In Vivo , 2016, Diabetes.
[5] R. Regazzi,et al. Postnatal β-cell maturation is associated with islet-specific microRNA changes induced by nutrient shifts at weaning , 2015, Nature Communications.
[6] Raphael Gottardo,et al. Orchestrating high-throughput genomic analysis with Bioconductor , 2015, Nature Methods.
[7] R. Scharfmann,et al. Development of a conditionally immortalized human pancreatic β cell line. , 2014, The Journal of clinical investigation.
[8] J. Nielsen,et al. Functional characteristics of neonatal rat β cells with distinct markers. , 2013, Journal of molecular endocrinology.
[9] H. Akiyama,et al. VHL-mediated disruption of Sox9 activity compromises β-cell identity and results in diabetes mellitus , 2013, Genes & development.
[10] C. Dang. MYC, metabolism, cell growth, and tumorigenesis. , 2013, Cold Spring Harbor perspectives in medicine.
[11] Maike Sander,et al. Inactivation of specific β cell transcription factors in type 2 diabetes. , 2013, The Journal of clinical investigation.
[12] G. Rutter,et al. When less is more: the forbidden fruits of gene repression in the adult β‐cell , 2013, Diabetes, obesity & metabolism.
[13] C. Talchai,et al. Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure , 2012, Cell.
[14] F. Schuit. Response to Comment on: Schuit et al. β-Cell–Specific Gene Repression: A Mechanism to Protect Against Inappropriate or Maladjusted Insulin Secretion? Diabetes 2012;61:969–975 , 2012, Diabetes.
[15] G. Crabtree,et al. Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT. , 2012, Developmental cell.
[16] G. Rutter,et al. Overexpression of Monocarboxylate Transporter-1 (Slc16a1) in Mouse Pancreatic β-Cells Leads to Relative Hyperinsulinism During Exercise , 2012, Diabetes.
[17] M. Granvik,et al. β-Cell–Specific Gene Repression: A Mechanism to Protect Against Inappropriate or Maladjusted Insulin Secretion? , 2012, Diabetes.
[18] Sinisa Hrvatin,et al. Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3 , 2012, Nature Biotechnology.
[19] Amy E. Cox,et al. cMyc is a principal upstream driver of beta-cell proliferation in rat insulinoma cell lines and is an effective mediator of human beta-cell replication. , 2011, Molecular endocrinology.
[20] S. Bonner-Weir,et al. Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells , 2011, Diabetologia.
[21] Amitabh Sharma,et al. Rat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells , 2011, Diabetologia.
[22] G. Morahan,et al. Faculty Opinions recommendation of Serotonin regulates pancreatic beta cell mass during pregnancy. , 2010 .
[23] C. Cobelli,et al. Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy , 2010, Diabetologia.
[24] K. Kaestner,et al. Expansion of β-cell mass in response to pregnancy , 2010, Trends in Endocrinology & Metabolism.
[25] Mark D. Robinson,et al. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data , 2009, Bioinform..
[26] J. Schug,et al. The transcriptional response of the islet to pregnancy in mice. , 2009, Molecular endocrinology.
[27] A. Tarakhovsky,et al. Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus. , 2009, Genes & development.
[28] A. Bhushan,et al. Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation. , 2009, Genes & development.
[29] J. Kushner,et al. Adaptive β-Cell Proliferation Is Severely Restricted With Advanced Age , 2009, Diabetes.
[30] T. Gurlo,et al. Age-Dependent Decline in β-Cell Proliferation Restricts the Capacity of β-Cell Regeneration in Mice , 2009, Diabetes.
[31] M. Hebrok,et al. A Role for von Hippel-Lindau Protein in Pancreatic β-Cell Function , 2009, Diabetes.
[32] M. Rupnik,et al. Exocytosis of Insulin , 2009, Annals of the New York Academy of Sciences.
[33] R. Rizza,et al. β-Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of β-Cell Mass in Humans , 2008, Diabetes.
[34] S. Pelengaris,et al. Effects of c-MYC activation on glucose stimulus-secretion coupling events in mouse pancreatic islets. , 2008, American journal of physiology. Endocrinology and metabolism.
[35] R. Mirmira. Faculty Opinions recommendation of Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans. , 2008 .
[36] G. Evan,et al. Regulated β-Cell Regeneration in the Adult Mouse Pancreas , 2008, Diabetes.
[37] M. Hebrok,et al. Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis. , 2006, Gastroenterology.
[38] G. Evan,et al. Reversible kinetic analysis of Myc targets in vivo provides novel insights into Myc-mediated tumorigenesis. , 2006, Cancer research.
[39] J. Kushner,et al. Very Slow Turnover of β-Cells in Aged Adult Mice , 2005 .
[40] M. German,et al. Hedgehog signaling regulates expansion of pancreatic epithelial cells. , 2005, Developmental biology.
[41] John S Lazo,et al. Low molecular weight inhibitors of Myc–Max interaction and function , 2003, Oncogene.
[42] Chunling Zhang,et al. Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[43] R. Palmiter,et al. Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes. , 2002, Diabetes.
[44] G. Evan,et al. Suppression of Myc-Induced Apoptosis in β Cells Exposes Multiple Oncogenic Properties of Myc and Triggers Carcinogenic Progression , 2002, Cell.
[45] M. Prentki,et al. Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion. , 2000, Diabetes.
[46] L. Orci,et al. Incomplete Processing of Proinsulin to Insulin Accompanied by Elevation of Des-31,32 Proinsulin Intermediates in Islets of Mice Lacking Active PC2* , 1998, The Journal of Biological Chemistry.
[47] J. Parsons,et al. Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion. , 1992, Endocrinology.
[48] T. Otonkoski,et al. Insulin and glucagon secretory responses to arginine, glucagon, and theophylline during perifusion of human fetal islet-like cell clusters. , 1988, The Journal of clinical endocrinology and metabolism.
[49] Gopika G. Nair,et al. Controlled induction of human pancreatic progenitors produces functional beta‐like cells in vitro , 2015, The EMBO journal.
[50] J. Pessin,et al. Insulin granule biogenesis, trafficking and exocytosis. , 2009, Vitamins and hormones.
[51] T. Gurlo,et al. Age-dependent Decline in Beta Cell Proliferation Restricts the Capacity of Beta Cell Regeneration in Mice , 2009 .
[52] J. Kushner,et al. ADAPTIVE BETA CELL PROLIFERATION IS SEVERELY RESTRICTED WITH ADVANCED AGE , 2009 .
[53] M. Rupnik,et al. In Vivo Maturation of Mouse Endocrine Pancreas , 2009 .
[54] T. Cheng,et al. Flow cytometry-based cell cycle measurement of mouse hematopoietic stem and progenitor cells. , 2008, Methods in molecular biology.
[55] Stella Pelengaris,et al. Regulated beta-cell regeneration in the adult mouse pancreas. , 2008, Diabetes.
[56] J. Kushner,et al. Very slow turnover of beta-cells in aged adult mice. , 2005, Diabetes.
[57] F. Alt,et al. Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. , 2001, Immunity.