Modeling of hemoglobin in dengue fever and dengue hemorrhagic fever using bioelectrical impedance.

This paper describes a model for predicting hemoglobin (Hb) by using bioelectrical impedance analysis (BIA) in dengue patients in the Hospital Universiti Kebangsaan Malaysia (HUKM). Bioelectrical impedance measurements were conducted on 83 (47 males and 36 females) serologically confirmed dengue fever (DF) and dengue hemorrhagic fever (DHF) patients during their hospitalization. The predictive equation for Hb was derived using multivariate analysis. We investigated all the parameters in BIA, patients' symptom and demographic data. In this developed model, four predictors (reactance (XC), sex, weight and vomiting) were found to be the best predictive factors for modeling Hb in dengue patients. However, the model can only explain approximately 42% of the variation in Hb status, thus single frequency bio-impedance stand-alone technique is insufficient to monitor Hb for the DF and DHF patients. Further investigation using multi-frequency BIA is recommended in modeling Hb to achieve the most parsimonious model.

[1]  S. Halstead,et al.  Antibody, macrophages, dengue virus infection, shock, and hemorrhage: a pathogenetic cascade. , 1989, Reviews of infectious diseases.

[2]  W. Abas,et al.  Assessment of haematocrit status using bioelectrical impedance analysis in dengue patients , 2003 .

[3]  E. Chungue,et al.  Intérêt du Titrage des IgM par Technique Immunoenzymatique Pour le Sérodiagnostic et la Surveillance Épidémiologique de la Dengue en Polynésie Française , 1989 .

[4]  P. Deurenberg,et al.  Hydrational Status Assessed by Bioelectrical Impedance Spectroscopy and Dilution Methods in Patients with Classical Dengue Fever , 2000, Annals of the New York Academy of Sciences.

[5]  H. Schwan.  Electrical properties of tissue and cell suspensions. , 1957, Advances in biological and medical physics.

[6]  M. Ja.  Application of total body bioimpedance to the critically ill patient. Brazilian Group for Bioimpedance Study. , 1996 .

[7]  R. Pethig,et al.  Dielectric properties of body tissues. , 1987, Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics.

[8]  Alan L Rothman,et al.  Assessment of body fluid compartment volumes by multifrequency bioelectrical impedance spectroscopy in children with dengue. , 2002, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[9]  H C Lukaski,et al.  Methods for the assessment of human body composition: traditional and new. , 1987, The American journal of clinical nutrition.

[10]  S. Devi,et al.  Detection of specific IgM in dengue infection. , 1987, The Southeast Asian journal of tropical medicine and public health.

[11]  H. Schwan,et al.  An electrical method to determine hematocrits. , 1960, IRE transactions on medical electronics.

[12]  H C Lukaski,et al.  Assessment of fat-free mass using bioelectrical impedance measurements of the human body. , 1985, The American journal of clinical nutrition.

[13]  I. Gartside,et al.  Noninvasive measurement of microvascular leakage in patients with dengue hemorrhagic fever. , 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[14]  S. Nimmannitya,et al.  Clinical spectrum and management of dengue haemorrhagic fever. , 1987, The Southeast Asian journal of tropical medicine and public health.

[15]  Wan Abu Bakar Wan Abas,et al.  Dengue fever (DF) and dengue haemorrhagic fever (DHF) symptoms analysis from an expert system perspective , 2001, Proceedings. IEEE International Multi Topic Conference, 2001. IEEE INMIC 2001. Technology for the 21st Century..

[16]  Fatimah Ibrahim,et al.  A novel approach to classify risk in dengue hemorrhagic fever (DHF) using bioelectrical impedance analysis (BIA) , 2005, IEEE Transactions on Instrumentation and Measurement.

[17]  Nelson Cv,et al.  Electronic measurement of blood sedimentation rate. , 1972 .

[18]  M. Mazariegos,et al.  Bioelectrical Impedance Spectroscopy in Health and Disease: Correspondence between Whole Body and Segmental Bioelectrical Impedance Spectroscopy Indices in Patients with Classical Dengue Fever , 2000, Annals of the New York Academy of Sciences.

[19]  R F Kushner,et al.  Bioelectrical impedance analysis: a review of principles and applications. , 1992, Journal of the American College of Nutrition.

[20]  A. Bottoni,et al.  Resistance and reactance in patients undergoing coronary artery bypass. , 2003, Nutricion hospitalaria.

[21]  R. Patterson,et al.  Development and evaluation of an impedance cardiac output system. , 1966, Aerospace medicine.

[22]  J P Morucci,et al.  Bioelectrical impedance techniques in medicine. Part I: Bioimpedance measurement. Second section: impedance spectrometry. , 1996, Critical reviews in biomedical engineering.