Aldol reaction under solvent-free conditions: highly stereoselective synthesis of 1,3-amino alcohols

[formula: see text] A method for the highly stereoselective synthesis of 1,3-amino alcohols based on the indium trichloride-catalyzed Mukaiyama aldol reaction of keto ester (R,S)-1 under solvent-free conditions has been developed. The high selectivity observed can be explained on the basis of the shielding of one face by a remote substituent.

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