HermesE: A 96-Channel Full Data Rate Direct Neural Interface in 0.13 $\mu$ m CMOS

A power and area efficient sensor interface consumes 6.4 mW from 1.2 V while occupying 5 mm × 5 mm in 0.13 μm CMOS. The interface offers simultaneous access to 96 channels of broadband neural data acquired from cortical microelectrodes as part of a head-mounted wireless recording system, enabling basic neuroscience as well as neuroprosthetics research. Signals are conditioned with a front-end achieving 2.2 μVrms input-referred noise in a 10 kHz bandwidth before conversion at 31.25 kSa/s by 10-bit SAR ADCs with 60.3 dB SNDR and 42 fJ/conv-step. Switched-capacitor filtering provides a well-controlled frequency response and utilizes windowed integrator sampling to mitigate noise aliasing, enhancing noise/power efficiency.

[1]  Bernhard E. Boser,et al.  3 A Mode-Matching ΔΣ Closed-Loop Vibratory-Gyroscope Readout Interface with a 0 . 004 ° / s / √ Hz Noise Floor over a 50 Hz Band , 2008 .

[2]  Jon A. Mukand,et al.  Neuronal ensemble control of prosthetic devices by a human with tetraplegia , 2006, Nature.

[3]  R.R. Harrison,et al.  A Low-Power Integrated Circuit for a Wireless 100-Electrode Neural Recording System , 2006, IEEE Journal of Solid-State Circuits.

[4]  R.R. Harrison,et al.  HermesC: Low-Power Wireless Neural Recording System for Freely Moving Primates , 2009, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[5]  Boris Murmann,et al.  An Analysis of Latch Comparator Offset Due to Load Capacitor Mismatch , 2006, IEEE Transactions on Circuits and Systems II: Express Briefs.

[6]  R.R. Harrison,et al.  Wireless Neural Recording With Single Low-Power Integrated Circuit , 2009, IEEE Transactions on Neural Systems and Rehabilitation Engineering.

[7]  Karim Abdelhalim,et al.  The 128-Channel Fully Differential Digital Integrated Neural Recording and Stimulation Interface , 2010, IEEE Transactions on Biomedical Circuits and Systems.

[8]  Moo Sung Chae,et al.  Design Optimization for Integrated Neural Recording Systems , 2008, IEEE Journal of Solid-State Circuits.

[9]  P. Gray,et al.  All-MOS charge redistribution analog-to-digital conversion techniques. I , 1975, IEEE Journal of Solid-State Circuits.

[10]  Michael P. Flynn,et al.  A 64 Channel Programmable Closed-Loop Neurostimulator With 8 Channel Neural Amplifier and Logarithmic ADC , 2010, IEEE Journal of Solid-State Circuits.

[11]  Karim Abdelhalim,et al.  128-channel fully differential digital neural recording and stimulation interface , 2009, 2009 IEEE International Symposium on Circuits and Systems.

[12]  B.E. Boser,et al.  A Mode-Matching $\Sigma\Delta$ Closed-Loop Vibratory Gyroscope Readout Interface With a 0.004$^{\circ}$ /s/$\surd{\hbox{Hz}}$ Noise Floor Over a 50 Hz Band , 2008, IEEE Journal of Solid-State Circuits.

[13]  Reid R. Harrison,et al.  The Design of Integrated Circuits to Observe Brain Activity , 2008, Proceedings of the IEEE.

[14]  Teresa H. Y. Meng,et al.  HermesD: A High-Rate Long-Range Wireless Transmission System for Simultaneous Multichannel Neural Recording Applications , 2010, IEEE Transactions on Biomedical Circuits and Systems.

[15]  Matthew T. Kaufman,et al.  Cortical Preparatory Activity: Representation of Movement or First Cog in a Dynamical Machine? , 2010, Neuron.

[16]  Rahul Sarpeshkar,et al.  An Energy-Efficient Micropower Neural Recording Amplifier , 2007, IEEE Transactions on Biomedical Circuits and Systems.

[17]  Anantha Chandrakasan,et al.  A Biomedical Sensor Interface With a sinc Filter and Interference Cancellation , 2011, IEEE Journal of Solid-State Circuits.

[18]  Vikash Gilja,et al.  Autonomous head-mounted electrophysiology systems for freely behaving primates , 2010, Current Opinion in Neurobiology.

[19]  M S Lewicki,et al.  A review of methods for spike sorting: the detection and classification of neural action potentials. , 1998, Network.

[20]  Jordi Parramon,et al.  A Micropower Low-Noise Neural Recording Front-End Circuit for Epileptic Seizure Detection , 2011, IEEE Journal of Solid-State Circuits.

[21]  J. Y. Lettvin,et al.  Comments on Microelectrodes , 1959, Proceedings of the IRE.

[22]  C.H. Diaz,et al.  CMOS technology for MS/RF SoC , 2003, 2004 IEEE Workshop on Microelectronics and Electron Devices.

[23]  Xinyu Xing,et al.  A 6.7nV/√Hz Sub-mHz-1/f-corner 14b analog-to-digital interface for rail-to-rail precision voltage sensing , 2011, 2011 IEEE International Solid-State Circuits Conference.

[24]  Teresa H. Y. Meng,et al.  HermesB: A Continuous Neural Recording System for Freely Behaving Primates , 2007, IEEE Transactions on Biomedical Engineering.

[25]  A.S. Sedra,et al.  Analog MOS integrated circuits for signal processing , 1987, Proceedings of the IEEE.

[26]  Moo Sung Chae,et al.  A 128-Channel 6mW Wireless Neural Recording IC with On-the-Fly Spike Sorting and UWB Tansmitter , 2008, 2008 IEEE International Solid-State Circuits Conference - Digest of Technical Papers.

[27]  Boris Murmann,et al.  A 96-channel full data rate direct neural interface in 0.13µm CMOS , 2011, 2011 Symposium on VLSI Circuits - Digest of Technical Papers.

[28]  Woradorn Wattanapanitch,et al.  An ultra-low-power neural recording amplifier and its use in adaptively-biased multi-amplifier arrays , 2007 .

[29]  J. Donoghue,et al.  Neural discharge and local field potential oscillations in primate motor cortex during voluntary movements. , 1998, Journal of neurophysiology.

[30]  Gang Xu,et al.  Performance analysis of general charge sampling , 2005, IEEE Trans. Circuits Syst. II Express Briefs.

[31]  Ahmad Mirzaei,et al.  Analysis of first-order anti-aliasing integration sampler , 2008, IEEE Transactions on Circuits and Systems I: Regular Papers.

[32]  Tamal Mukherjee,et al.  High-speed low-power integrating CMOS sample-and-hold amplifier architecture , 1995, Proceedings of the IEEE 1995 Custom Integrated Circuits Conference.

[33]  Robert G. Meyer,et al.  Analysis and Design of Analog Integrated Circuits , 1993 .

[34]  Teresa H. Y. Meng,et al.  A programmable pulse UWB transmitter with 34% energy efficiency for multichannel neuro-recording systems , 2010, IEEE Custom Integrated Circuits Conference 2010.

[35]  W.M.C. Sansen,et al.  A micropower low-noise monolithic instrumentation amplifier for medical purposes , 1987 .

[36]  Craig T. Nordhausen,et al.  Optimizing recording capabilities of the Utah Intracortical Electrode Array , 1994, Brain Research.

[37]  Jiren Yuan A charge sampling mixer with embedded filter function for wireless applications , 2000, ICMMT 2000. 2000 2nd International Conference on Microwave and Millimeter Wave Technology Proceedings (Cat. No.00EX364).

[38]  Andrew B Schwartz,et al.  Cortical neural prosthetics. , 2004, Annual review of neuroscience.

[39]  Pierluigi Nuzzo,et al.  Noise Analysis of Regenerative Comparators for Reconfigurable ADC Architectures , 2008, IEEE Transactions on Circuits and Systems I: Regular Papers.