Computer-aided Discovery of Peptides that Specifically Attack Bacterial Biofilms

[1]  P. Newell,et al.  Form Follows Function , 2018, Loudspeakers.

[2]  J. D’Cunha The matrix revisited. , 2018, The Journal of thoracic and cardiovascular surgery.

[3]  R. Hancock,et al.  Aggregation and Its Influence on the Immunomodulatory Activity of Synthetic Innate Defense Regulator Peptides. , 2017, Cell chemical biology.

[4]  R. Hancock,et al.  Bacterial Abscess Formation Is Controlled by the Stringent Stress Response and Can Be Targeted Therapeutically , 2016, EBioMedicine.

[5]  R. Hancock,et al.  High throughput screening methods for assessing antibiofilm and immunomodulatory activities of synthetic peptides , 2015, Peptides.

[6]  R. Hancock,et al.  Peptide IDR‐1018: modulating the immune system and targeting bacterial biofilms to treat antibiotic‐resistant bacterial infections , 2015, Journal of peptide science : an official publication of the European Peptide Society.

[7]  Y. Marrero-Ponce,et al.  Towards Better BBB Passage Prediction Using an Extensive and Curated Data Set , 2015, Molecular informatics.

[8]  Suzana M. Ribeiro,et al.  Antibiofilm Peptides Increase the Susceptibility of Carbapenemase-Producing Klebsiella pneumoniae Clinical Isolates to β-Lactam Antibiotics , 2015, Antimicrobial Agents and Chemotherapy.

[9]  R. Hancock,et al.  D-enantiomeric peptides that eradicate wild-type and multidrug-resistant biofilms and protect against lethal Pseudomonas aeruginosa infections. , 2015, Chemistry & biology.

[10]  G. Maccari,et al.  BaAMPs: the database of biofilm-active antimicrobial peptides , 2015, Biofouling.

[11]  R. Hancock,et al.  A Broad-Spectrum Antibiofilm Peptide Enhances Antibiotic Action against Bacterial Biofilms , 2014, Antimicrobial Agents and Chemotherapy.

[12]  R. Hancock,et al.  Broad-Spectrum Anti-biofilm Peptide That Targets a Cellular Stress Response , 2014, PLoS pathogens.

[13]  Antibiotic resistance—the need for global solutions , 2014, BDJ.

[14]  J. Dearden,et al.  QSAR modeling: where have you been? Where are you going to? , 2014, Journal of medicinal chemistry.

[15]  M. V. van Hoek,et al.  Biofilms , 2013, Virulence.

[16]  Robert E W Hancock,et al.  Peptide design for antimicrobial and immunomodulatory applications. , 2013, Biopolymers.

[17]  Sun-Hee Park,et al.  Investigation of Biofilm Formation and its Association with the Molecular and Clinical Characteristics of Methicillin-resistant Staphylococcus aureus , 2013, Osong public health and research perspectives.

[18]  Robert E W Hancock,et al.  Bacterial biofilm development as a multicellular adaptation: antibiotic resistance and new therapeutic strategies. , 2013, Current opinion in microbiology.

[19]  D. Lebeaux,et al.  From in vitro to in vivo Models of Bacterial Biofilm-Related Infections , 2013, Pathogens.

[20]  A. Cardona,et al.  Fiji: an open-source platform for biological-image analysis , 2012, Nature Methods.

[21]  V. Korolik,et al.  Inhibition of Bacterial Biofilm Formation and Swarming Motility by a Small Synthetic Cationic Peptide , 2012, Antimicrobial Agents and Chemotherapy.

[22]  G. Schneider,et al.  Designing antimicrobial peptides: form follows function , 2011, Nature Reviews Drug Discovery.

[23]  T. Hashiguchi,et al.  Quantitative analysis of biofilm formation of methicillin-resistant Staphylococcus aureus (MRSA) strains from patients with orthopaedic device-related infections. , 2011, FEMS immunology and medical microbiology.

[24]  H. Vogel,et al.  The expanding scope of antimicrobial peptide structures and their modes of action. , 2011, Trends in biotechnology.

[25]  Kai Hilpert,et al.  Structural studies of a peptide with immune modulating and direct antimicrobial activity. , 2010, Chemistry & biology.

[26]  Thomas Bjarnsholt,et al.  Antibiotic resistance of bacterial biofilms. , 2010, International journal of antimicrobial agents.

[27]  Artem Cherkasov,et al.  Use of artificial intelligence in the design of small peptide antibiotics effective against a broad spectrum of highly antibiotic-resistant superbugs. , 2009, ACS chemical biology.

[28]  R. Hancock,et al.  Human Host Defense Peptide LL-37 Prevents Bacterial Biofilm Formation , 2008, Infection and Immunity.

[29]  Artem Cherkasov,et al.  QSAR modeling and computer‐aided design of antimicrobial peptides , 2008, Journal of peptide science : an official publication of the European Peptide Society.

[30]  Artem Cherkasov,et al.  Evaluating Different Descriptors for Model Design of Antimicrobial Peptides with Enhanced Activity Toward P. aeruginosa , 2007, Chemical biology & drug design.

[31]  R. Hancock,et al.  Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies , 2006, Nature Biotechnology.

[32]  H. Vogel,et al.  Tryptophan- and arginine-rich antimicrobial peptides: structures and mechanisms of action. , 2006, Biochimica et biophysica acta.

[33]  D. Davidson,et al.  Impact of LL‐37 on anti‐infective immunity , 2005, Journal of leukocyte biology.

[34]  A. S. Kabankin,et al.  Relationship Between Structure and Hepatoprotector Activity of Adamantane Derivatives. Part 2. Application of Autocorrelative, Substructural, and 3D Molecular Descriptors , 2005, Pharmaceutical Chemistry Journal.

[35]  Artem Cherkasov,et al.  Inductive Electronegativity Scale. Iterative Calculation of Inductive Partial Charges , 2003, J. Chem. Inf. Comput. Sci..

[36]  Roberto Todeschini,et al.  Structure/Response Correlations and Similarity/Diversity Analysis by GETAWAY Descriptors, 1. Theory of the Novel 3D Molecular Descriptors , 2002, J. Chem. Inf. Comput. Sci..

[37]  Paola Gramatica,et al.  Structure/Response Correlations and Similarity/Diversity Analysis by GETAWAY Descriptors, 2. Application of the Novel 3D Molecular Descriptors to QSAR/QSPR Studies , 2002, J. Chem. Inf. Comput. Sci..

[38]  Pierre Baldi,et al.  Assessing the accuracy of prediction algorithms for classification: an overview , 2000, Bioinform..

[39]  J. Costerton,et al.  Bacterial biofilms: a common cause of persistent infections. , 1999, Science.

[40]  Johann Gasteiger,et al.  Deriving the 3D structure of organic molecules from their infrared spectra , 1999 .

[41]  Artem Cherkasov,et al.  A NEW APPROACH TO THE THEORETICAL ESTIMATION OF INDUCTIVE CONSTANTS , 1998 .

[42]  J. Schuur,et al.  Infrared Spectra Simulation of Substituted Benzene Derivatives on the Basis of a 3D Structure Representation. , 1997, Analytical chemistry.

[43]  Johann Gasteiger,et al.  The Coding of the Three-Dimensional Structure of Molecules by Molecular Transforms and Its Application to Structure-Spectra Correlations and Studies of Biological Activity , 1996, J. Chem. Inf. Comput. Sci..

[44]  R. Hancock,et al.  Synthesis of peptide arrays using SPOT-technology and the CelluSpots-method. , 2009, Methods in molecular biology.

[45]  R. Hancock,et al.  Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances , 2008, Nature Protocols.

[46]  A. Cherkasov Inductive Descriptors: 10 Successful Years in QSAR , 2005 .

[47]  Roberto Kolter,et al.  Biofilms: the matrix revisited. , 2005, Trends in microbiology.

[48]  Rajakrishnan Rajkumar,et al.  Grammar Engineering for CCG using Ant and XSLT ∗ , 2001 .