Radioactive Coil Embolisation of Intracranial Aneurysms

Coil embolisation of intracranial aneurysms can improve the outcome of patients treated after subarachnoid haemorrage as compared to surgical clipping 1. Unfortunately, angiographic recurrences are not infrequent and although their clinical significance remains to be determined, they may be responsible for future ruptures2. In situ beta radiation, using coils ion-implanted with 32P, may prevent recanalization and thus improve long-term results of endovascular treatment. The present article will review the experimental data as well as present the clinical feasibility of radioactive coil embolisation of intracranial aneurysms.

[1]  J. Lamoureux,et al.  Long-Term Angiographic Recurrences After Selective Endovascular Treatment of Aneurysms With Detachable Coils , 2003, Stroke.

[2]  J. Raymond,et al.  Beta Radiation and Inhibition of Recanalization After Coil Embolization of Canine Arteries and Experimental Aneurysms: How Should Radiation Be Delivered? , 2003, Stroke.

[3]  A. Weill,et al.  Radioactive Embolization of Intracranial Aneurysms Using 32P-Implanted Coils , 2003, Stroke.

[4]  A. Molyneux International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial , 2002, The Lancet.

[5]  D. Kallmes,et al.  New expandable hydrogel-platinum coil hybrid device for aneurysm embolization. , 2002, AJNR. American journal of neuroradiology.

[6]  JeanRaymond,et al.  In Situ Beta Radiation to Prevent Recanalization After Coil Embolization of Cerebral Aneurysms , 2002 .

[7]  C. Janicki Comment on "Self-absorption correction for 32P, 198Au, and 188Re stents: dose point kernel calculations versus Monte Carlo". , 2002, Medical physics.

[8]  S. Tateshima,et al.  Bioabsorbable polymeric material coils for embolization of intracranial aneurysms: a preliminary experimental study. , 2001, Journal of neurosurgery.

[9]  L. Fig,et al.  Intracavitary therapy of craniopharyngiomas. , 1999, The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology.