Oral Health Effects of Combusted and Smokeless Tobacco Products

The oral cavity is usually the first part of a consumer’s body exposed to the constituents of tobacco products or their emissions. Consequently, the oral cavity is a frequent site for carcinogenic, microbial, immunologic, and clinical effects of tobacco use. This article summarizes 5 presentations on various aspects of oral health affected by combusted or noncombusted tobacco products from a recent conference, “Oral Health Effects of Tobacco Products: Science and Regulatory Policy,” sponsored by the American Association for Dental Research and the Food and Drug Administration.

[1]  I. Jaspers,et al.  Cinnamaldehyde in flavored e-cigarette liquids temporarily suppresses bronchial epithelial cell ciliary motility by dysregulation of mitochondrial function. , 2019, American journal of physiology. Lung cellular and molecular physiology.

[2]  Brian A. King,et al.  Flavored Tobacco Product Use Among Middle and High School Students — United States, 2014–2018 , 2015, MMWR. Morbidity and mortality weekly report.

[3]  Brian A. King,et al.  Notes from the Field: Use of Electronic Cigarettes and Any Tobacco Product Among Middle and High School Students — United States, 2011–2018 , 2018, MMWR. Morbidity and mortality weekly report.

[4]  P. Anastas,et al.  Formation of flavorant-propylene Glycol Adducts With Novel Toxicological Properties in Chemically Unstable E-Cigarette Liquids. , 2018, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[5]  Laura E. Herring,et al.  Chronic E‐Cigarette Exposure Alters the Human Bronchial Epithelial Proteome , 2018, American journal of respiratory and critical care medicine.

[6]  A. Balhaddad,et al.  Effects of Nicotine on Oral Microorganisms, Human Tissues, and the Interactions between Them , 2018, Current Oral Health Reports.

[7]  Xuedong Zhou,et al.  Nicotine is a risk factor for dental caries: An in vivo study , 2018, Journal of dental sciences.

[8]  G. Radicioni,et al.  E‐Cigarette Use Causes a Unique Innate Immune Response in the Lung, Involving Increased Neutrophilic Activation and Altered Mucin Secretion , 2017, American journal of respiratory and critical care medicine.

[9]  R. Strongin,et al.  Formaldehyde Hemiacetal Sampling, Recovery, and Quantification from Electronic Cigarette Aerosols , 2017, Scientific Reports.

[10]  G. Glish,et al.  Flavored e-cigarette liquids and cinnamaldehyde impair respiratory innate immune cell function. , 2017, American journal of physiology. Lung cellular and molecular physiology.

[11]  L. Johnston,et al.  Demographic subgroup trends among adolescents in the use of various licit and illicit drugs, 1975-2016 (Monitoring the Future Occasional Paper No. 88) , 2017 .

[12]  Jennifer L. Pearson,et al.  Flavored Tobacco Product Use in Youth and Adults: Findings From the First Wave of the PATH Study (2013-2014). , 2017, American journal of preventive medicine.

[13]  Kenneth M Taylor,et al.  Tobacco-Specific Nitrosamines in the Tobacco and Mainstream Smoke of U.S. Commercial Cigarettes. , 2017, Chemical research in toxicology.

[14]  S. Amin,et al.  Carcinogenesis of the Oral Cavity: Environmental Causes and Potential Prevention by Black Raspberry. , 2017, Chemical research in toxicology.

[15]  P. Ling,et al.  Tobacco industry use of flavourings to promote smokeless tobacco products , 2016, Tobacco Control.

[16]  P. Talbot,et al.  Distribution, quantification and toxicity of cinnamaldehyde in electronic cigarette refill fluids and aerosols , 2016, Tobacco Control.

[17]  H. Destaillats,et al.  Emissions from Electronic Cigarettes: Key Parameters Affecting the Release of Harmful Chemicals. , 2016, Environmental science & technology.

[18]  Xuedong Zhou,et al.  Effect of nicotine on cariogenic virulence of Streptococcus mutans , 2016, Folia Microbiologica.

[19]  Neal L. Benowitz,et al.  Electronic Cigarettes : Not All Good News ? E-cigarette use results in suppression of immune and inflammatory-response genes in nasal epithelial cells similar to cigarette smoke , 2016 .

[20]  A. Holmlund,et al.  Prevalence of dental caries and influencing factors, time trends over a 30-year period in an adult population. Epidemiological studies between 1983 and 2013 in the county of Dalarna, Sweden , 2016, Acta odontologica Scandinavica.

[21]  D. Hatsukami,et al.  Call to Establish Constituent Standards for Smokeless Tobacco Products , 2016 .

[22]  R. Courtney,et al.  The Health Consequences of Smoking-50 Years of Progress: A Report of the Surgeon General, 2014Us Department of Health and Human Services Atlanta, GA: Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for: Critique , 2015 .

[23]  Brian A. King,et al.  Flavored Tobacco Product Use Among Middle and High School Students--United States, 2014. , 2015, MMWR. Morbidity and mortality weekly report.

[24]  Mingyun Li,et al.  Nicotine promotes Streptococcus mutans extracellular polysaccharide synthesis, cell aggregation and overall lactate dehydrogenase activity. , 2015, Archives of oral biology.

[25]  B. Lindgren,et al.  Evidence Supporting Product Standards for Carcinogens in Smokeless Tobacco Products , 2014, Cancer Prevention Research.

[26]  M. Parascandola,et al.  Smokeless tobacco and public health : a global perspective , 2014 .

[27]  T. Hanioka,et al.  Daily smoking may independently predict caries development in adults. , 2014, The journal of evidence-based dental practice.

[28]  I. Jaspers.  Cigarette smoke effects on innate immune mechanisms in the nasal mucosa. Potential effects on the microbiome. , 2014, Annals of the American Thoracic Society.

[29]  B. Paster,et al.  Bacterial profiles of saliva in relation to diet, lifestyle factors, and socioeconomic status , 2014, Journal of oral microbiology.

[30]  Patrick M. O'Malley,et al.  Demographic subgroup trends among adolescents in the use of various licit and illicit drugs, 1975-2015 , 2014 .

[31]  Y Wang,et al.  Identification of Toxicants in Cinnamon-Flavored Electronic Cigarette Refill Fluids. , 2014, Toxicology in vitro : an international journal published in association with BIBRA.

[32]  S. Hecht,et al.  (S)-N'-Nitrosonornicotine, a constituent of smokeless tobacco, is a powerful oral cavity carcinogen in rats. , 2013, Carcinogenesis.

[33]  D. Hatsukami,et al.  Nornicotine nitrosation in saliva and its relation to endogenous synthesis of N'-nitrosonornicotine in humans. , 2013, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[34]  D. Hatsukami,et al.  Flavored and nonflavored smokeless tobacco products: rate, pattern of use, and effects. , 2013, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[35]  Olivia A. Wackowski,et al.  Examining market trends in the United States smokeless tobacco use: 2005–2011 , 2012, Tobacco Control.

[36]  Mingyun Li,et al.  Effect of nicotine on growth and metabolism of Streptococcus mutans. , 2012, European journal of oral sciences.

[37]  S. Hecht,et al.  Research opportunities related to establishing standards for tobacco products under the Family Smoking Prevention and Tobacco Control Act. , 2012, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

[38]  Jian-Min Yuan,et al.  Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokers. , 2011, Carcinogenesis.

[39]  Mingyun Li,et al.  Bacterial interactions in dental biofilm , 2011, Virulence.

[40]  R. Greer.  Oral manifestations of smokeless tobacco use. , 2011, Otolaryngologic clinics of North America.

[41]  G. Campus,et al.  Does Smoking Increase Risk for Caries? A Cross-Sectional Study in an Italian Military Academy , 2011, Caries Research.

[42]  L. Windsor,et al.  Smoking and oral health. , 2011, Journal - Oklahoma Dental Association.

[43]  Jian-Min Yuan,et al.  Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention. , 2010, Chemical research in toxicology.

[44]  J. Wennström,et al.  Oral health risks of tobacco use and effects of cessation. , 2010, International dental journal.

[45]  S. Burchiel,et al.  Some non-heterocyclic polycyclic aromatic hydrocarbons and some related exposures. , 2010, IARC monographs on the evaluation of carcinogenic risks to humans.

[46]  G. Connolly,et al.  Patterns of dual use of cigarettes and smokeless tobacco among US males: findings from national surveys , 2009, Tobacco Control.

[47]  Y. Bek,et al.  Association of passive smoking with caries and related salivary biomarkers in young children. , 2008, Archives of oral biology.

[48]  G. Maupomé,et al.  Cigarette Smoking and Dental Caries among Professional Truck Drivers in Mexico , 2008, Caries Research.

[49]  Iarc Monographs,et al.  Smokeless tobacco and some tobacco-specific N-nitrosamines. , 2007, IARC monographs on the evaluation of carcinogenic risks to humans.

[50]  G. Taylor,et al.  Smokeless Tobacco and Severe Active Periodontal Disease, NHANES III , 2005, Journal of dental research.

[51]  Dorothy K Hatsukami,et al.  Smokeless tobacco use: harm reduction or induction approach? , 2004, Preventive medicine.

[52]  Office on Smoking.  The Health Consequences of Smoking: A Report of the Surgeon General , 2004 .

[53]  M. Thun,et al.  Tobacco smoke and involuntary smoking. , 2004, IARC monographs on the evaluation of carcinogenic risks to humans.

[54]  C. Bain,et al.  Tobacco Intervention: Tobacco and oral disease , 2000, British Dental Journal.

[55]  S. Tomar,et al.  Smoking-Attributable Periodontitis in the United States: Findings From NHANES III. , 2000, Journal of periodontology.

[56]  C. Bain,et al.  Tobacco and oral disease , 2000 .

[57]  C. Bain,et al.  Tobacco and oral disease. EU-Working Group on Tobacco and Oral Health. , 2000, British dental journal.

[58]  D. Winn,et al.  Chewing tobacco use and dental caries among U.S. men. , 1999, Journal of the American Dental Association.

[59]  S. Hecht,et al.  Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines. , 1998, Chemical research in toxicology.

[60]  J. Henningfield,et al.  Review of the evidence that pH is a determinant of nicotine dosage from oral use of smokeless tobacco. , 1997, Tobacco control.

[61]  P. Robertson,et al.  Oral Effects of Smokeless Tobacco Use by Professional Baseball Players , 1997, Advances in dental research.

[62]  R. Woody,et al.  Abrasive particles in tobacco products: a possible factor in dental attrition. , 1995, Journal of the American Dental Association.

[63]  M. Djordjevic,et al.  Effects of storage conditions on levels of tobacco-specific N-nitrosamines and N-nitrosamino acids in U.S. moist snuff , 1993 .

[64]  G. Oilo,et al.  Abrasives in snuff? , 1989, Acta odontologica Scandinavica.

[65]  A. Ekfeldt.  Incisal and occlusal tooth wear and wear of some prosthodontic materials. An epidemiological and clinical study. , 1989, Swedish dental journal. Supplement.