论文信息 - A New Cycloartanol Sulfate from the Green Alga Tuemoya Sp.: An Inhibitor of VZV Protease

A New Cycloartanol Sulfate from the Green Alga Tuemoya Sp.: An Inhibitor of VZV Protease

Abstract As part of a search for novel inhibitors of Herpes Zoster protease, the MeOH extract of the green alga Tuemoya sp. was shown to be active. Bioassay-guided fractionation of the extract yielded a previously reported cycloartane-3,28-disulfate-23-ol plus a novel compound that was identified as cycloart-24-en-23-one-28-sulfate-3-ol (1). These compounds demonstrated activity against both VZV and CMV protease in the 4–7 μM range.

A. Freyer | L. Killmer | Randall K. Johnson | A. Breen | A. D. Patil

[1] R. Johnson,et al. Halistanol disulfate B, a novel sulfated sterol from the sponge Pachastrella sp.: inhibitor of endothelin converting enzyme. , 1996, Journal of natural products.

[2] J. Papkoff,et al. New cycloartanol sulfates from the alga Tydemania expeditionis: inhibitors of the protein tyrosine kinase pp60v-src. , 1994, Journal of natural products.

[3] H. Achenbach,et al. Cycloartanes and other terpenoids and phenylpropanoids from Monocyclanthus vignei , 1992 .

[4] H. Krebs. Recent developments in the field of marine natural products with emphasis on biologically active compounds. , 1986, Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progres dans la chimie des substances organiques naturelles.