The potent synthetic androgens, dimethandrolone (7α,11β-dimethyl-19-nortestosterone) and 11β-methyl-19-nortestosterone, do not require 5α-reduction to exert their maximal androgenic effects
暂无分享,去创建一个
J. Reel | T. Pham | B. Attardi | J. Engbring | Laurent Pessaint | S. Koduri | S. Hild | Bruce A Till | D. Gropp | Anne Semon
[1] A. Matsumoto,et al. Long-term effects of dimethandrolone 17β-undecanoate and 11β-methyl-19-nortestosterone 17β-dodecylcarbonate on body composition, bone mineral density, serum gonadotropins, and androgenic/anabolic activity in castrated male rats. , 2011, Journal of andrology.
[2] A. Matsumoto,et al. Long-Term Effects of Dimethandrolone 17Beta-Undecanoate (DMAU) and 11Beta-Methyl-19-Nortestosterone 17Beta-Dodecylcarbonate (11Beta-MNTDC) on Body Composition, Bone Mineral Density (BMD), Serum Gonadotropins, and Androgenic/Anabolic Activity in Castrated Male Rats. , 2009 .
[3] J. Reel,et al. Dimethandrolone (7α,11β-dimethyl-19-nortestosterone) and 11β-methyl-19-nortestosterone are not converted to aromatic A-ring products in the presence of recombinant human aromatase , 2008, The Journal of Steroid Biochemistry and Molecular Biology.
[4] J. Reel,et al. Dimethandrolone undecanoate: a new potent orally active androgen with progestational activity. , 2006, Endocrinology.
[5] J. Dalton,et al. Chemistry and structural biology of androgen receptor. , 2005, Chemical reviews.
[6] D. Tindall,et al. Dihydrotestosterone and the prostate: the scientific rationale for 5alpha-reductase inhibitors in the treatment of benign prostatic hyperplasia. , 2004, The Journal of urology.
[7] M. Oettel. The endocrine pharmacology of testosterone therapy in men , 2004, Naturwissenschaften.
[8] M. Byrne,et al. Testosterone replacement therapy in male hypogonadism , 2003, Journal of endocrinological investigation.
[9] Culley Carson,et al. The role of dihydrotestosterone in benign prostatic hyperplasia. , 2003, Urology.
[10] J. Reel,et al. CDB-4124 and its putative monodemethylated metabolite, CDB-4453, are potent antiprogestins with reduced antiglucocorticoid activity: in vitro comparison to mifepristone and CDB-2914 , 2002, Molecular and Cellular Endocrinology.
[11] M. K. James,et al. Unique preclinical characteristics of GG745, a potent dual inhibitor of 5AR. , 1997, The Journal of pharmacology and experimental therapeutics.
[12] C. Bardin,et al. Different patterns of metabolism determine the relative anabolic activity of 19-norandrogens , 1995, The Journal of Steroid Biochemistry and Molecular Biology.
[13] Y. Ito,et al. Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. , 1994, Endocrine reviews.
[14] C. Bardin,et al. The biological activity of 7 alpha-methyl-19-nortestosterone is not amplified in male reproductive tract as is that of testosterone. , 1992, Endocrinology.
[15] C. Bardin,et al. Radioimmunoassay of 7α-methyl-19-nortestosterone and investigation of its pharmacokinetics in animals , 1990, The Journal of Steroid Biochemistry and Molecular Biology.
[16] R. G. Christiansen,et al. Antiandrogenic steroidal sulfonylpyrazoles. , 1990, Journal of medicinal chemistry.
[17] C. Monder,et al. In Vitro Metabolism of 7α-Methyl-19-Nortestosterone by Rat Liver, Prostate, and Epididymis , 1988 .
[18] W F Raub,et al. The PROPHET system and resource sharing. , 1974, Federation proceedings.
[19] R. K. Meyer,et al. Myotrophic Activity of 19-Nortestosterone and Other Steroids Determined by Modified Levator Ani Muscle Method.∗ , 1953, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.