Iron‐TEMPO‐Catalyzed Domino Aerobic Alcohol Oxidation/Oxidative Cross‐Dehydrogenative Coupling for the Synthesis of α‐Keto Amides

An iron-TEMPO-catalyzed (TEMPO = 2,2,6,6-tetramethyl-1-piperidinyloxy), aerobic process was developed to synthesize α-keto amides. This reaction proceeds through a domino alcohol oxidation/oxidative cross-dehydrogenative coupling sequence, uses 2-hydroxyacetophenones and amines as the starting materials, and takes place under molecular oxygen, which makes the transformation highly efficient, practical, and environmentally friendly.

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