In this paper, we consider the design methodology of a mobile patient hub for the remote self-management of COPD patients. The patient hub design forms a part of the WELCOME system. WELCOME is a current EU project that aims to design and develop a new mobile health system to provide integrated care for COPD patients with comorbidities. The approach adopted for this research is based on the Web of Things architecture with RESTful principles as the enabler of communications. The proposed patient hub architecture design is based on three layers: an application layer, a middleware layer and the sensors layer. This paper presents the detail of the initial design of the middleware and an analysis of the architecture in the context of the system's requirements.