Polymorphism of rs873308 near the transmembrane protein 57 gene is associated with serum lipid levels.

The single nucleotide polymorphism (SNP) of rs10903129 near the transmembrane protein (TMEM) 57 locus was associated with total cholesterol (TC) in a previous genome-wide association study, but the association of TMEM57 rs873308 SNP and serum lipid levels has not been previously reported. The genotypic and allelic frequencies of the TMEM57 rs873308 SNP in 865 individuals of Han Chinese and 902 participants of Mulao nationality was determined by polymerase chain and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing.The T allele frequency of TMEM57 rs873308 SNP was different between Han and Mulao (17.80% vs. 25.72%, P < 0.001), or between males and females in the two ethnic groups (P < 0.05). The T allele carriers had lower serum TC and ApoB and higher HDL-C levels and the ApoA1/ApoB ratio in Han; and lower TG, LDL-C, ApoA1 levels and the ApoA1/ApoB ratio and higher HDL-C levels in Mulao than the T allele non-carriers. There was also different association of the TMEM57 rs873308 SNP and serum lipid profiles between males and females in the both ethnic groups. Serum lipid parameters in the two ethnic groups were also associated with several environmental factors.The association of the TMEM57 rs873308 SNP and serum lipid levels was different in the Chinese Han and Mulao populations and between males and females in the both ethnic groups. The difference in serum lipid profiles between the two ethnic groups might partly result from different TMEM57 rs873308 SNP.

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