Canagliflozin alleviates experimentally induced benign prostate hyperplasia in a rat model: exploring potential mechanisms involving mir-128b/EGFR/EGF and JAK2/STAT3 signaling pathways through in silico and in vivo investigations.

[1]  Kawkab A. Ahmed,et al.  Donepezil halts acetic acid-induced experimental colitis in rats and its associated cognitive impairment through regulating inflammatory/oxidative/apoptotic cascades: An add-on to its anti-dementia activity. , 2023, International immunopharmacology.

[2]  Dongning Li,et al.  A Network Pharmacology to Explore the Potential Targets of Canagliflozin and Dapagliflozin in Treating Atherosclerosis , 2022, Journal of Vascular Diseases.

[3]  Jing Yuan,et al.  SGLT2 inhibitor, canagliflozin, ameliorates cardiac inflammation in experimental autoimmune myocarditis. , 2022, International immunopharmacology.

[4]  Jing Ke,et al.  SGLT2 inhibition restrains thyroid cancer growth via G1/S phase transition arrest and apoptosis mediated by DNA damage response signaling pathways , 2022, Cancer cell international.

[5]  M. El-Sherbiny,et al.  Diacerein ameliorates testosterone-induced benign prostatic hyperplasia in rats: Effect on oxidative stress, inflammation and apoptosis. , 2021, International immunopharmacology.

[6]  M. Morsy,et al.  Canagliflozin, an SGLT-2 inhibitor, ameliorates acetic acid-induced colitis in rats through targeting glucose metabolism and inhibiting NOX2. , 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[7]  S. Chiragh,et al.  EFFECT OF CANAGLIFLOZIN ALONE AND IN COMBINATION WITH METFORMIN ON HORMONAL DERANGEMENTS AND ESTROUS CYCLE IN A POLYCYSTIC OVARY SYNDROME RAT MODEL , 2021, Khyber Medical University Journal.

[8]  Yup Kang,et al.  Anti-inflammatory Effects of Empagliflozin and Gemigliptin on LPS-Stimulated Macrophage via the IKK/NF-κB, MKK7/JNK, and JAK2/STAT1 Signalling Pathways , 2021, Journal of immunology research.

[9]  M. Azadbakht,et al.  Evaluation of Juniperus communis L. seed extract on benign prostatic hyperplasia induced in male Wistar rats , 2021, African Journal of Urology.

[10]  A. Abdel-Naim,et al.  Piceatannol Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats by Modulation of Nrf2/HO-1/NFκB Axis , 2020, Frontiers in Pharmacology.

[11]  Qiang Zhang,et al.  Sodium-glucose co-transporter-2 (SGLT-2) inhibition reduces glucose uptake to induce breast cancer cell growth arrest through AMPK/mTOR pathway. , 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[12]  A. Abdel-Naim,et al.  Febuxostat attenuates testosterone-induced benign prostatic hyperplasia in rats via inhibiting JAK/STAT axis. , 2020, Life sciences.

[13]  Farzana Zerin,et al.  Canagliflozin ameliorates renal oxidative stress and inflammation by stimulating AMPK–Akt–eNOS pathway in the isoprenaline-induced oxidative stress model , 2020, Scientific Reports.

[14]  Farzana Zerin,et al.  Canagliflozin attenuates isoprenaline-induced cardiac oxidative stress by stimulating multiple antioxidant and anti-inflammatory signaling pathways , 2020, Scientific Reports.

[15]  H. Helmy,et al.  Immunomodulatory effect of diallyl sulfide on experimentally-induced benign prostate hyperplasia via the suppression of CD4+T/IL-17 and TGF-β1/ERK pathways , 2020, Inflammopharmacology.

[16]  W. Durante,et al.  Canagliflozin inhibits vascular smooth muscle cell proliferation and migration: Role of heme oxygenase-1 , 2020, Redox biology.

[17]  G. Helmlinger,et al.  Differentiating the Sodium‐Glucose Cotransporter 1 Inhibition Capacity of Canagliflozin vs. Dapagliflozin and Empagliflozin Using Quantitative Systems Pharmacology Modeling , 2020, CPT: pharmacometrics & systems pharmacology.

[18]  Dongqing Wang,et al.  MicroRNA-128-b regulates epidermal growth factor receptor expression in non-small cell lung cancer , 2019, Molecular medicine reports.

[19]  Y. Aso,et al.  The SGLT2 Inhibitor Canagliflozin Prevents Carcinogenesis in a Mouse Model of Diabetes and Non-Alcoholic Steatohepatitis-Related Hepatocarcinogenesis: Association with SGLT2 Expression in Hepatocellular Carcinoma , 2019, International journal of molecular sciences.

[20]  A. I. Abdelaziz,et al.  Activation of pCREB/Nrf-2 signaling mediates re-positioning of liraglutide as hepato-protective for methotrexate -induced liver injury (MILI). , 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[21]  John W. Nicholson,et al.  PREFACE TO THE THIRD EDITION , 2019, Plants of the San Francisco Bay Region.

[22]  A. Abdel-Naim,et al.  Cucurbitacin E glucoside from Citrullus colocynthis inhibits testosterone-induced benign prostatic hyperplasia in mice , 2019, Drug and chemical toxicology.

[23]  Yuan He,et al.  The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation , 2019, International journal of molecular sciences.

[24]  F. Schaper,et al.  Robustness and Information Transfer within IL-6-induced JAK/STAT Signalling , 2019, Communications Biology.

[25]  Josip Madunić,et al.  Sodium-glucose cotransporters: new targets of cancer therapy? , 2018, Arhiv za higijenu rada i toksikologiju.

[26]  B. Chung,et al.  Efficacy and safety of 5 alpha-reductase inhibitor monotherapy in patients with benign prostatic hyperplasia: A meta-analysis , 2018, PloS one.

[27]  M. Hollenberg,et al.  Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress. , 2018, Vascular pharmacology.

[28]  S. Sikka,et al.  Targeting Crosstalk between Nrf-2, NF-κB and Androgen Receptor Signaling in Prostate Cancer , 2018, Cancers.

[29]  A. Shalaby,et al.  Effect of canagliflozin, a sodium glucose co-transporter 2 inhibitor, on cisplatin-induced nephrotoxicity in mice , 2018, Naunyn-Schmiedeberg's Archives of Pharmacology.

[30]  T. Anwer,et al.  The combination of canagliflozin and omega-3 fatty acid ameliorates insulin resistance and cardiac biomarkers via modulation of inflammatory cytokines in type 2 diabetic rats , 2018, The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology.

[31]  Hamidreza Montazeri Aliabadi,et al.  “Do We Know Jack” About JAK? A Closer Look at JAK/STAT Signaling Pathway , 2018, Front. Oncol..

[32]  Wei Wang,et al.  Canagliflozin exerts anti‐inflammatory effects by inhibiting intracellular glucose metabolism and promoting autophagy in immune cells , 2018, Biochemical pharmacology.

[33]  A. Taille,et al.  Prostatic inflammation: a potential treatment target for male LUTS due to benign prostatic obstruction , 2018, Prostate Cancer and Prostatic Diseases.

[34]  H. Yoshiji,et al.  Sodium glucose cotransporter 2 inhibitor canagliflozin attenuates liver cancer cell growth and angiogenic activity by inhibiting glucose uptake , 2018, International journal of cancer.

[35]  Tetsuhiro Tanaka,et al.  The Anticipated Renoprotective Effects of Sodium-glucose Cotransporter 2 Inhibitors , 2018, Internal medicine.

[36]  Hongtao Chen,et al.  Therapeutic Effect of Sodium Glucose Co-Transporter 2 Inhibitor Dapagliflozin on Renal Cell Carcinoma , 2017, Medical science monitor : international medical journal of experimental and clinical research.

[37]  Zhiguang Qiao,et al.  Oxytocin: its role in benign prostatic hyperplasia via the ERK pathway. , 2017, Clinical science.

[38]  Lun Li,et al.  The anti-hyperplasia, anti-oxidative and anti-inflammatory properties of Qing Ye Dan and swertiamarin in testosterone-induced benign prostatic hyperplasia in rats. , 2017, Toxicology letters.

[39]  G. Guelfi,et al.  Different levels of serum microRNAs in prostate cancer and benign prostatic hyperplasia: evaluation of potential diagnostic and prognostic role , 2016, OncoTargets and therapy.

[40]  Ayman E El-Sahar,et al.  Dapoxetine attenuates testosterone-induced prostatic hyperplasia in rats by the regulation of inflammatory and apoptotic proteins. , 2016, Toxicology and applied pharmacology.

[41]  Kyung-Sook Chung,et al.  Musulju improves benign prostatic hyperplasia by regulating inflammatory and apoptotic proteins , 2016, Molecular medicine reports.

[42]  D. Fitchett,et al.  Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus: Cardiovascular and Kidney Effects, Potential Mechanisms, and Clinical Applications. , 2016, Circulation.

[43]  P. Muti,et al.  The diabetes medication Canagliflozin reduces cancer cell proliferation by inhibiting mitochondrial complex-I supported respiration , 2016, Molecular metabolism.

[44]  A. Sinclair,et al.  Efficacy and Safety of Canagliflozin in Individuals Aged 75 and Older with Type 2 Diabetes Mellitus: A Pooled Analysis , 2016, Journal of the American Geriatrics Society.

[45]  J. Xiong,et al.  MiR-128b is down-regulated in gastric cancer and negatively regulates tumour cell viability by targeting PDK1/Akt/NF-κB axis , 2016, Journal of Biosciences.

[46]  S. Yamagishi,et al.  Tofogliflozin, A Highly Selective Inhibitor of SGLT2 Blocks Proinflammatory and Proapoptotic Effects of Glucose Overload on Proximal Tubular Cells Partly by Suppressing Oxidative Stress Generation , 2015, Hormone and Metabolic Research.

[47]  Jie Yu,et al.  miR-128 modulates chemosensitivity and invasion of prostate cancer cells through targeting ZEB1. , 2015, Japanese journal of clinical oncology.

[48]  M. Marberger.  Medical Management of Lower Urinary Tract Symptoms in Men with Benign Prostatic Enlargement , 2013, Advances in Therapy.

[49]  Jiumao Lin,et al.  Qianliening capsule treats benign prostatic hyperplasia via suppression of the EGF/STAT3 signaling pathway , 2013, Experimental and therapeutic medicine.

[50]  R. Kurzrock,et al.  A kinase-independent biological activity for insulin growth factor-1 receptor (IGF-1R): Implications for Inhibition of the IGF-1R signal , 2013, Oncotarget.

[51]  J. Elkahwaji.  The role of inflammatory mediators in the development of prostatic hyperplasia and prostate cancer , 2012, Research and reports in urology.

[52]  M. Hung,et al.  Sodium/Glucose Co-transporter 1 Expression Increases in Human Diseased Prostate , 2012 .

[53]  Roman A. Laskowski,et al.  LigPlot+: Multiple Ligand-Protein Interaction Diagrams for Drug Discovery , 2011, J. Chem. Inf. Model..

[54]  N. Saini,et al.  MicroRNA-128 downregulates Bax and induces apoptosis in human embryonic kidney cells , 2011, Cellular and Molecular Life Sciences.

[55]  N. Kyprianou,et al.  Androgen receptor and growth factor signaling cross-talk in prostate cancer cells. , 2008, Endocrine-related cancer.

[56]  B. Liu,et al.  Activation of Signal Transducers and Activators of Transcription 3 and Overexpression of its Target Gene CyclinD1 in Laryngeal Carcinomas , 2008, The Laryngoscope.

[57]  C. Barnstable,et al.  STAT3 activation in response to growth factors or cytokines participates in retina precursor proliferation. , 2005, Experimental eye research.

[58]  Sheng-Chieh Hsu,et al.  Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway. , 2005, Cancer cell.

[59]  Chenguang Wang,et al.  Minireview: Cyclin D1: normal and abnormal functions. , 2004, Endocrinology.

[60]  Douglas L. Jones,et al.  Mortality After Myocardial Infarction in Mice , 2022 .

[61]  H. Drexler,et al.  Expression, activity and functional significance of inducible nitric oxide synthase in the failing human heart. , 1998, Journal of the American College of Cardiology.

[62]  OUP accepted manuscript , 2022, Nucleic Acids Research.

[63]  A. Scheen.  Pharmacodynamics, Efficacy and Safety of Sodium–Glucose Co-Transporter Type 2 (SGLT2) Inhibitors for the Treatment of Type 2 Diabetes Mellitus , 2014, Drugs.