Sleep disturbance in movement disorders: insights, treatments and challenges

Sleep and circadian rhythm disturbances are central features of many movement disorders, exacerbating motor and non-motor symptoms and impairing quality of life. Understanding these disturbances to sleep is clinically important and may further our understanding of the underlying movement disorder. This review evaluates the current anatomical and neurochemical understanding of normal sleep and the recognised primary sleep disorders. In addition, we undertook a systematic review of the evidence for disruption to sleep across multiple movement disorders. Rapid eye movement sleep behaviour disorder has emerged as the most reliable prodromal biomarker for the alpha synucleinopathies, including Parkinson’s disease and multiple system atrophy, often preceding motor symptom onset by several years. Abnormal sleep has also been described for many other movement disorders, but further evidence is needed to determine whether this is a primary or secondary phenotypic component of the underlying condition. Medication used in the treatment of motor symptoms also affects sleep and can aggravate or cause certain sleep disorders. Within the context of movement disorders, there is also some suggestion of a shared underlying mechanism for motor and sleep pathophysiology, with evidence implicating thalamic and brainstem structures and monoaminergic neurotransmission. This review highlights the need for an understanding of normal and abnormal sleep within the movement disorder clinic, an ability to screen for specific causes of poor sleep and to treat sleep disturbance to improve quality of life. Key sleep disorders also act as important biomarkers and have implications in diagnosis, prognosis and the development of future therapies.

[1]  P. Krack,et al.  A case series and systematic review of rapid eye movement sleep behavior disorder outcome after deep brain stimulation in Parkinson's disease. , 2020, Sleep medicine.

[2]  Min-ting Lin,et al.  Ataxic Severity Is Positively Correlated With Fatigue in Spinocerebellar Ataxia Type 3 Patients , 2020, Frontiers in Neurology.

[3]  P. Pal,et al.  The Non-Motor Symptom Profile of Progressive Supranuclear Palsy , 2020, Journal of movement disorders.

[4]  R. Peng,et al.  Distinct non‐motor features of essential tremor with head tremor patients , 2020, Acta neurologica Scandinavica.

[5]  F. Jiménez-Jiménez,et al.  Sleep Disorders in Essential Tremor: Systematic Review and Meta-Analysis. , 2020, Sleep.

[6]  L. Sanford,et al.  Sleep in Parkinson's disease: A systematic review and meta-analysis of polysomnographic findings. , 2020, Sleep medicine reviews.

[7]  T. Charman,et al.  Sleep difficulties in children with Tourette syndrome and chronic tic disorders: A systematic review of characteristics and associated factors. , 2019, Sleep.

[8]  Xinglong Yang,et al.  Clinical characteristics of patients with essential tremor or essential tremor plus , 2019, Acta neurologica Scandinavica.

[9]  P. Pan,et al.  Obstructive sleep apnea in Parkinson's disease: a study in 239 Chinese patients. , 2019, Sleep medicine.

[10]  Yalan Chen,et al.  Clinical features of multiple system atrophy with or without rapid eye movement behavior disorder: a cross-sectional study in southwest China , 2019, Clinical Autonomic Research.

[11]  A. Shalash,et al.  Clinical Profile of Non-Motor Symptoms in Patients with Essential Tremor: Impact on Quality of Life and Age-Related Differences , 2019, Tremor and other hyperkinetic movements.

[12]  S. Lehéricy,et al.  Multimodal Magnetic Resonance Imaging Quantification of Brain Changes in Progressive Supranuclear Palsy , 2019, Movement disorders : official journal of the Movement Disorder Society.

[13]  Julie M. Hall,et al.  Melatonin for rapid eye movement sleep behavior disorder in Parkinson's disease: A randomised controlled trial , 2019, Movement disorders : official journal of the Movement Disorder Society.

[14]  Hiroshi Kataoka,et al.  Objective sleep measures between patients with Parkinson's disease and community-based older adults. , 2019, Sleep medicine.

[15]  J. Santamaria,et al.  Characterization of the sleep disorder of anti-IgLON5 disease. , 2019, Sleep.

[16]  J. Broman,et al.  A 10-Year Follow-Up of Excessive Daytime Sleepiness in Parkinson's Disease , 2019, Parkinson's disease.

[17]  M. H. Chagas,et al.  Obstructive sleep apnea and Parkinson's disease: characteristics and associated factors. , 2019, Arquivos de neuro-psiquiatria.

[18]  L. Lopiano,et al.  Sleep microstructure in Parkinson's disease: cycling alternating pattern (CAP) as a sensitive marker of early NREM sleep instability. , 2019, Sleep medicine.

[19]  S. Marino,et al.  Potential predictors of quality of life in Parkinson’s Disease: Sleep and mood disorders , 2019, Journal of Clinical Neuroscience.

[20]  Guo-En Cai,et al.  Sleep fragmentation as an important clinical characteristic of sleep disorders in Parkinson's disease: a preliminary study , 2019, Chinese medical journal.

[21]  R. Rodríguez-Labrada,et al.  Sleep spindles and K-complex activities are decreased in spinocerebellar ataxia type 2: relationship to memory and motor performances. , 2019, Sleep medicine.

[22]  A. Berardelli,et al.  Motor and non-motor symptoms in blepharospasm: clinical and pathophysiological implications , 2019, Journal of Neurology.

[23]  J. Bower,et al.  Prevalence of sleep disorders in Parkinson’s disease patients in two neurology referral hospitals in Ethiopia , 2019, BMC Neurology.

[24]  A. Lleó,et al.  Clinical and Video-Polysomnographic Analysis of Rem Sleep Behavior Disorder and other Sleep Disturbances in Dementia with Lewy Bodies. , 2019, Sleep.

[25]  J. Jankovic,et al.  Comprehensive systematic review summary: Treatment of tics in people with Tourette syndrome and chronic tic disorders , 2019, Neurology.

[26]  P. Braga-Neto,et al.  Sleep disorders in NiemannPick disease type C, beyond cataplexy. , 2019, Sleep medicine.

[27]  A. Quattrone,et al.  REM-Sleep Behavior Disorder in Patients With Essential Tremor: What Is Its Clinical Significance? , 2019, Front. Neurol..

[28]  P. Pal,et al.  Impaired sleep quality and cognition in patients of Parkinson's disease with REM sleep behavior disorder: a comparative study. , 2019, Sleep medicine.

[29]  Yoon H Cho,et al.  Neurophysiological and Behavioral Effects of Anti-Orexinergic Treatments in a Mouse Model of Huntington’s Disease , 2019, Neurotherapeutics.

[30]  F. Valldeoriola,et al.  Non-motor symptoms in Huntington’s disease: a comparative study with Parkinson’s disease , 2019, Journal of Neurology.

[31]  P. Bugalho,et al.  Polysomnographic data in Dementia with Lewy Bodies: correlation with clinical symptoms and comparison with other α-synucleinopathies. , 2019, Sleep medicine.

[32]  Yves Dauvilliers,et al.  Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study , 2019, Brain : a journal of neurology.

[33]  Xiaodong Zhu,et al.  Polysomnographic and neuropsychological characteristics of rapid eye movement sleep behavior disorder patients , 2019, Brain and behavior.

[34]  R. Bhidayasiri,et al.  Association between Sleep Disturbances and Daytime Somnolence in Parkinson’s Disease , 2019, European Neurology.

[35]  V. Tumas,et al.  The Prevalence and Correlation of Non-motor Symptoms in Adult Patients with Idiopathic Focal or Segmental Dystonia , 2019, Tremor and other hyperkinetic movements.

[36]  G. Plazzi,et al.  Persistence of limb dystonia and myoclonus during sleep in corticobasal syndrome: a case series. , 2019, Sleep medicine.

[37]  Hao Chi,et al.  Tauopathy , 2019, Cognitive Disorders.

[38]  Y. Takiyama,et al.  Spinocerebellar ataxia type 31 associated with REM sleep behavior disorder: a case report , 2019, BMC Neurology.

[39]  L. Morales-Chacón,et al.  Analysis of Sleep Macrostructure in Patients Diagnosed with Parkinson’s Disease , 2019, Behavioral sciences.

[40]  P. Stanzione,et al.  Levodopa‐induced dyskinesia in Parkinson disease: Sleep matters , 2018, Annals of neurology.

[41]  S. Ancoli-Israel,et al.  Nighttime Sleep and Daytime Sleepiness Improved With Pimavanserin During Treatment of Parkinson’s Disease Psychosis , 2018, Clinical neuropharmacology.

[42]  H. Shill,et al.  Predicting alpha-synuclein pathology by REM sleep behavior disorder diagnosis. , 2018, Parkinsonism & related disorders.

[43]  C. Colwell,et al.  4.2 Piloting Actigraphy for the Assessment of Sleep Functioning in Youth With Persistent Tic Disorders , 2018, Journal of the American Academy of Child & Adolescent Psychiatry.

[44]  A. Takakura,et al.  Correlation between neuroanatomical and functional respiratory changes observed in an experimental model of Parkinson's disease , 2018, Experimental physiology.

[45]  A. Walters,et al.  Deep brain stimulation improves restless legs syndrome in patients with Parkinson disease , 2018, Neurology.

[46]  J. Pedroso,et al.  Sleep apnea in Machado-Joseph disease: a clinical and polysomnographic evaluation. , 2018, Sleep medicine.

[47]  Julie A E Christensen,et al.  Comparison of computerized methods for rapid eye movement sleep without atonia detection , 2018, Sleep.

[48]  Anders M. Dale,et al.  Brain-wide glymphatic enhancement and clearance in humans assessed with MRI. , 2018, JCI insight.

[49]  J. Kulisevsky,et al.  Circadian Rhythm, Cognition, and Mood Disorders in Huntington's Disease. , 2018, Journal of Huntington's disease.

[50]  Jianfang Ma,et al.  A haplotype of MAP2K5/SKOR1 was associated with essential tremor in Chinese population. , 2018, Parkinsonism & related disorders.

[51]  D. Bowers,et al.  Sleep disturbances and depression severity in patients with Parkinson's disease , 2018, Brain and behavior.

[52]  A. Rana,et al.  Decreased sleep quality in Parkinson’s patients is associated with higher anxiety and depression prevalence and severity, and correlates with pain intensity and quality , 2018, Neurological research.

[53]  T. Ashizawa,et al.  Sleep disorders in spinocerebellar ataxia type 10 , 2018, Journal of sleep research.

[54]  J. Yun,et al.  Sleep Related Problems as a Nonmotor Symptom of Dentatorubropallidoluysian Atrophy , 2018, Journal of Korean medical science.

[55]  H. Reichmann,et al.  Rasagiline improves polysomnographic sleep parameters in patients with Parkinson's disease: a double‐blind, baseline‐controlled trial , 2018, European journal of neurology.

[56]  Sanjeev Jain,et al.  Assessment of Sleep Spindle Density among Genetically Positive Spinocerebellar Ataxias Types 1, 2, and 3 Patients , 2018, Annals of Neurosciences.

[57]  D. Grabli,et al.  Stridor combined with other sleep breathing disorders in multiple system atrophy: a tailored treatment? , 2018, Sleep medicine.

[58]  Jing Yang,et al.  Impact of sleep-related breathing disorder on motor and non-motor symptoms in multiple system atrophy , 2018, Sleep and Breathing.

[59]  P. Bugalho,et al.  Probable REM-Sleep Behavior Disorder and Dysautonomic Symptoms in Essential Tremor , 2017, Tremor and other hyperkinetic movements.

[60]  T. Acar,et al.  Essential Tremor is not Only a Movement Disorder; Its Relationship with Sleep and Anxiety. , 2017, Noro psikiyatri arsivi.

[61]  Xiangrong Zhang,et al.  Depression and associated factors in nondemented Chinese patients with Parkinson’s disease , 2017, Clinical Neurology and Neurosurgery.

[62]  J. Olgin,et al.  Wilson's Disease and Cardiac Myopathy. , 2017, The American journal of cardiology.

[63]  A. Bentivoglio,et al.  Subjective Assessment of Sleep in Huntington Disease: Reliability of Sleep Questionnaires Compared to Polysomnography , 2017, Neurodegenerative Diseases.

[64]  K. Black Treatment of Parkinson's disease psychosis. , 2017, Medicina internacia revuo.

[65]  Christine M. Walsh,et al.  Sleepless Night and Day, the Plight of Progressive Supranuclear Palsy , 2017, Sleep.

[66]  M. H. Chagas,et al.  High Frequency of Sleep Disorders in Parkinson’s Disease and Its Relationship with Quality of Life , 2017, European Neurology.

[67]  B. Kutty,et al.  Challenges in sleep stage R scoring in patients with autosomal dominant spinocerebellar ataxias (SCA1, SCA2 and SCA3) and oculomotor abnormalities: a whole night polysomnographic evaluation. , 2017, Sleep medicine.

[68]  D. Weiss,et al.  Botulinumtoxin Improves both Generic and Disease-Specific Quality of Life in Cervical Dystonia , 2017, Front. Neurol..

[69]  K. Hirata,et al.  Restless legs syndrome, leg motor restlessness and their variants in patients with Parkinson's disease and related disorders , 2017, Journal of the Neurological Sciences.

[70]  C. Colwell,et al.  Sleep Sufficiency in Pediatric and Adolescent Tourette's Disorder: National Survey of Children's Health , 2017, Journal of developmental and behavioral pediatrics : JDBP.

[71]  J. J. Lee,et al.  Rapid eye movement sleep behaviour disorder and striatal dopamine depletion in patients with Parkinson's disease , 2017, European journal of neurology.

[72]  Lama M Chahine,et al.  A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015. , 2017, Sleep medicine reviews.

[73]  P. Nopoulos,et al.  A survey-based study identifies common but unrecognized symptoms in a large series of juvenile Huntington's disease. , 2017, Neurodegenerative disease management.

[74]  Ying-Zu Huang,et al.  Sleep disturbances in Taiwanese patients with Parkinson's disease , 2017, Brain and behavior.

[75]  K. Josephs,et al.  IgLON5 antibody , 2017, Neurology: Neuroimmunology & Neuroinflammation.

[76]  G. Plazzi,et al.  Modulation of the Muscle Activity During Sleep in Cervical Dystonia , 2017, Sleep.

[77]  C. Marini,et al.  Obstructive sleep apnea syndrome in Parkinson's disease and other parkinsonisms. , 2017, Functional neurology.

[78]  T. Ashizawa,et al.  Nonmotor Symptoms in Patients with Spinocerebellar Ataxia Type 10 , 2017, The Cerebellum.

[79]  Clifford B Saper,et al.  Wake–sleep circuitry: an overview , 2017, Current Opinion in Neurobiology.

[80]  T. Shimohata,et al.  Natural course and potential prognostic factors for sleep-disordered breathing in multiple system atrophy. , 2017, Sleep medicine.

[81]  N. Brüggemann,et al.  Clinical manifestations of the anti-IgLON5 disease , 2017, Neurology.

[82]  H. Benali,et al.  Pedunculopontine network dysfunction in Parkinson's disease with postural control and sleep disorders , 2017, Movement disorders : official journal of the Movement Disorder Society.

[83]  K. Yoshiyama,et al.  Effects of donepezil on sleep disturbances in patients with dementia with Lewy bodies: An open-label study with actigraphy , 2017, Psychiatry Research.

[84]  D. Barrett,et al.  Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice , 2017, Brain : a journal of neurology.

[85]  Xiaobo Pan,et al.  Cognitive Function Characteristics of Parkinson's Disease with Sleep Disorders , 2017, Parkinson's disease.

[86]  M. Siemiński,et al.  Sleeping difficulties and health‐related quality of life in Parkinson's disease , 2017, Acta neurologica Scandinavica.

[87]  Xudong Li,et al.  Transcranial sonography in idiopathic REM sleep behavior disorder and multiple system atrophy , 2017, Psychiatry and clinical neurosciences.

[88]  T. Lange,et al.  Course of Tourette Syndrome and Comorbidities in a Large Prospective Clinical Study. , 2017, Journal of the American Academy of Child and Adolescent Psychiatry.

[89]  Shinn-Ying Ho,et al.  Tourette Syndrome as an Independent Risk Factor for Subsequent Sleep Disorders in Children: A Nationwide Population-Based Case–Control Study , 2017, Sleep.

[90]  H. Katzen,et al.  Insomnia, Sleep Quality, and Quality of Life in Mild to Moderate Parkinson's Disease , 2017, Annals of the American Thoracic Society.

[91]  Zheng Xue,et al.  Clinical characteristics of sleep disorders in patients with Parkinson’s disease , 2017, Journal of Huazhong University of Science and Technology [Medical Sciences].

[92]  E. Fonoff,et al.  Restless legs syndrome in Wilson's disease: frequency, characteristics, and mimics , 2017, Acta neurologica Scandinavica.

[93]  Jing Yang,et al.  Non-motor symptoms and the quality of life in multiple system atrophy with different subtypes. , 2017, Parkinsonism & related disorders.

[94]  I. Ghorayeb,et al.  Impact of sleep apnea syndrome on survival in patients with multiple system atrophy. , 2017, Parkinsonism & related disorders.

[95]  J. Pedroso,et al.  Non-motor and Extracerebellar Features in Spinocerebellar Ataxia Type 2 , 2017, The Cerebellum.

[96]  T. Banaschewski,et al.  Opposite Impact of REM Sleep on Neurobehavioral Functioning in Children with Common Psychiatric Disorders Compared to Typically Developing Children , 2017, Front. Psychol..

[97]  A. Cagnin,et al.  Sleep-Wake Profile in Dementia with Lewy Bodies, Alzheimer's Disease, and Normal Aging. , 2016, Journal of Alzheimer's disease : JAD.

[98]  Jing Yang,et al.  Nonmotor symptoms in primary adult‐onset cervical dystonia and blepharospasm , 2016, Brain and behavior.

[99]  E. Huey,et al.  Daytime sleepiness and nighttime sleep quality across the full spectrum of cognitive presentations in essential tremor , 2016, Journal of the Neurological Sciences.

[100]  Tie-mei Zhang,et al.  Nonmotor symptoms in patients with Parkinson disease , 2016, Medicine.

[101]  Nicolas Sauvageot,et al.  Reduced Rapid Eye Movement Density in Parkinson Disease: A Polysomnography-Based Case-Control Study. , 2016, Sleep.

[102]  Daniela Berg,et al.  Advances in markers of prodromal Parkinson disease , 2016, Nature Reviews Neurology.

[103]  M. Todisco,et al.  Specific patterns of laryngeal electromyography during wakefulness are associated to sleep disordered breathing and nocturnal stridor in multiple system atrophy. , 2016, Parkinsonism & related disorders.

[104]  M. Okun,et al.  High rates of fatigue and sleep disturbances in dystonia , 2016, The International journal of neuroscience.

[105]  K. Anand,et al.  Impact of sleep quality on the quality of life of patients with Parkinson’s disease: a questionnaire based study , 2016, Clinical Neurology and Neurosurgery.

[106]  B. Mollenhauer,et al.  The Evolution of REM Sleep Behavior Disorder in Early Parkinson Disease. , 2016, Sleep.

[107]  O. Bruni,et al.  Sleep, anxiety and psychiatric symptoms in children with Tourette syndrome and tic disorders. , 2016, European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society.

[108]  Yen-Lin Chen,et al.  Depression as the Primary Cause of Insomnia and Excessive Daytime Sleepiness in a Family with Multiple Cases of Spinocerebellar Ataxia. , 2016, Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.

[109]  A. Rao,et al.  Essential tremor-Parkinson's disease: A double whammy , 2016, Journal of the Neurological Sciences.

[110]  J. Pedroso,et al.  Polysomnography findings in spinocerebellar ataxia type 6 , 2016, Journal of sleep research.

[111]  W. Poewe,et al.  Neuropathological criteria of anti-IgLON5-related tauopathy , 2016, Acta Neuropathologica.

[112]  M. Vidailhet,et al.  Does Postural Rigidity Decrease during REM Sleep without Atonia in Parkinson Disease? , 2016, Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.

[113]  A. Castro Caldas,et al.  Pharmacological interventions for daytime sleepiness and sleep disorders in Parkinson's disease: Systematic review and meta-analysis. , 2016, Parkinsonism & related disorders.

[114]  D. Louis Collins,et al.  Structural Brain Alterations Associated with Rapid Eye Movement Sleep Behavior Disorder in Parkinson’s Disease , 2016, Scientific Reports.

[115]  O. Hansson,et al.  The Swedish SCOPA-SLEEP for assessment of sleep disorders in Parkinson’s disease and healthy controls , 2016, Quality of Life Research.

[116]  G. Egan,et al.  Subjective sleep problems in Huntington's disease: A pilot investigation of the relationship to brain structure, neurocognitive, and neuropsychiatric function , 2016, Journal of the Neurological Sciences.

[117]  D. Rusakov,et al.  Do Astrocytes Respond To Dopamine , 2016 .

[118]  G. Landouré,et al.  Sleep quality assessment in 35 Parkinson's disease patients in the Fann Teaching Hospital, Dakar, Senegal. , 2016, Revue neurologique.

[119]  F. García-Río,et al.  Central Apneas and REM Sleep Behavior Disorder as an Initial Presentation of Multiple System Atrophy. , 2016, Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.

[120]  Seong-Beom Koh,et al.  Comparison of motor and non-motor features between essential tremor and tremor dominant Parkinson's disease , 2016, Journal of the Neurological Sciences.

[121]  J. Pedroso,et al.  NREM‐related parasomnias in Machado–Joseph disease: clinical and polysomnographic evaluation , 2016, Journal of sleep research.

[122]  M. T. Pellecchia,et al.  A Four-Year Longitudinal Study on Restless Legs Syndrome in Parkinson Disease. , 2016, Sleep.

[123]  T. Scammell,et al.  Bradysomnia in Parkinson’s disease , 2016, Clinical Neurophysiology.

[124]  A. Picco,et al.  Parkinson’s Disease Sleep Scale 2: application in an Italian population , 2016, Neurological Sciences.

[125]  M. Martín-Baranera,et al.  Agomelatine for Depression in Parkinson Disease: Additional Effect on Sleep and Motor Dysfunction , 2015, Journal of clinical psychopharmacology.

[126]  I. Jaussent,et al.  Daytime sleepiness in Parkinson's disease , 2015 .

[127]  Dag Aarsland,et al.  Higher Frequency and Complexity of Sleep Disturbances in Dementia with Lewy Bodies as Compared to Alzheimer's Disease , 2015, Neurodegenerative Diseases.

[128]  M. Mishima,et al.  Use of a new generation of adaptive servo ventilation for sleep-disordered breathing in patients with multiple system atrophy , 2015, BMJ Case Reports.

[129]  M. Okun,et al.  A Polysomnographic Study of Parkinson's Disease Sleep Architecture , 2015, Parkinson's disease.

[130]  C. Cámara-Lemarroy,et al.  Non-motor symptoms and quality of life in patients with Parkinson’s disease in Northeastern Mexico , 2015, Acta Neurologica Belgica.

[131]  A. Bentivoglio,et al.  Polysomnographic Findings and Clinical Correlates in Huntington Disease: A Cross-Sectional Cohort Study. , 2015, Sleep.

[132]  B. Bakım,et al.  Cognitive functions, fatigue, depression, anxiety, and sleep disturbances: assessment of nonmotor features in young patients with essential tremor , 2015, Acta Neurologica Belgica.

[133]  S. Lazic,et al.  Sleep deficits but no metabolic deficits in premanifest Huntington's disease , 2015, Annals of neurology.

[134]  E. Louis,et al.  Motor and Non-motor Features: Differences between Patients with Isolated Essential Tremor and Patients with Both Essential Tremor and Parkinson’s Disease , 2015, Tremor and other hyperkinetic movements.

[135]  Í. Lopes-Cendes,et al.  Fatigue is frequent and severe in spinocerebellar ataxia type 1. , 2015, Parkinsonism & related disorders.

[136]  A. Durr,et al.  Nocturnal agitation in Huntington disease is caused by arousal-related abnormal movements rather than by rapid eye movement sleep behavior disorder. , 2015, Sleep medicine.

[137]  D. Mijatović,et al.  Effects of various factors on sleep disorders and quality of life in Parkinson’s disease , 2015, Acta Neurologica Belgica.

[138]  P. Derost,et al.  Emergence of restless legs syndrome after subthalamic stimulation in Parkinson's disease: a dopaminergic overstimulation? , 2015, Sleep medicine.

[139]  Günther J. L. Gerhardt,et al.  NREM sleep alpha and sigma activity in Parkinson’s disease: Evidence for conflicting electrophysiological activity? , 2015, Clinical Neurophysiology.

[140]  G. Oyama,et al.  High frequency of beta-propeller protein-associated neurodegeneration (BPAN) among patients with intellectual disability and young-onset parkinsonism , 2015, Neurobiology of Aging.

[141]  Julie A. E. Christensen,et al.  Sleep spindle alterations in patients with Parkinson's disease , 2015, Front. Hum. Neurosci..

[142]  M. Partinen,et al.  Parkinson's disease and narcolepsy-like symptoms. , 2015, Sleep medicine.

[143]  P. Barone,et al.  Diagnosis and treatment of restless legs syndrome in progressive supranuclear palsy , 2015, Journal of the Neurological Sciences.

[144]  O. Rascol,et al.  Distinctive Features of NREM Parasomnia Behaviors in Parkinson’s Disease and Multiple System Atrophy , 2015, PloS one.

[145]  J. Iriarte,et al.  Prevalence of REM sleep behavior disorder in multiple system atrophy: a multicenter study and meta-analysis , 2015, Clinical Autonomic Research.

[146]  M. Kapoor,et al.  Spectrum of sleep disorders in a patient with spinocerebellar ataxia 13. , 2015, Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.

[147]  Kyum-Yil Kwon,et al.  Nonmotor symptoms in essential tremor: Comparison with Parkinson's disease and normal control , 2015, Journal of the Neurological Sciences.

[148]  A. Bentivoglio,et al.  Rapid eye movement sleep behavior disorder: a window on the emotional world of Parkinson disease. , 2015, Sleep.

[149]  R. Petersen,et al.  Abnormal daytime sleepiness in dementia with Lewy bodies compared to Alzheimer’s disease using the Multiple Sleep Latency Test , 2014, Alzheimer’s Research & Therapy.

[150]  N. Hattori,et al.  Rotigotine vs ropinirole in advanced stage Parkinson's disease: a double-blind study. , 2014, Parkinsonism & related disorders.

[151]  K. Chaudhuri,et al.  Nonmotor symptoms and focal cervical dystonia: Observations from 102 patients , 2014 .

[152]  R. Munhoz,et al.  REM sleep behaviour disorder: How useful is it for the differential diagnosis of parkinsonism? , 2014, Clinical Neurology and Neurosurgery.

[153]  P. Cortelli,et al.  Cognitive and Sleep Features of Multiple System Atrophy: Review and Prospective Study , 2014, European Neurology.

[154]  S. Prabhakar,et al.  Sleep disturbances in drug naïve Parkinson's disease (PD) patients and effect of levodopa on sleep , 2014, Annals of Indian Academy of Neurology.

[155]  N. Jodoin,et al.  Increased Prevalence of Non-motor Symptoms in Essential Tremor , 2014, Tremor and other hyperkinetic movements.

[156]  G. Tribl,et al.  Wilson's disease presenting as rapid eye movement sleep behavior disorder: a possible window to early treatment. , 2014, Arquivos de neuro-psiquiatria.

[157]  S. Ancoli-Israel,et al.  Parkinson's disease and REM sleep behavior disorder result in increased non-motor symptoms. , 2014, Sleep medicine.

[158]  F. Marrosu,et al.  Time structure of leg movement activity during sleep in untreated Parkinson disease and effects of dopaminergic treatment. , 2014, Sleep medicine.

[159]  A. Rothner,et al.  Sleep disorders in children with Tourette syndrome. , 2014, Pediatric neurology.

[160]  P. Pal,et al.  Alterations in Polysomnographic (PSG) profile in drug-naïve Parkinson's disease , 2014, Annals of Indian Academy of Neurology.

[161]  Alex Iranzo,et al.  A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study , 2014, The Lancet Neurology.

[162]  I. Ghorayeb,et al.  Restless legs syndrome in multiple system atrophy , 2014, Journal of Neural Transmission.

[163]  R. Barker,et al.  Sleep and circadian rhythm regulation in early Parkinson disease. , 2014, JAMA neurology.

[164]  G. B. Zimatore,et al.  Change in Non-motor Symptoms in Parkinson's Disease and Essential Tremor Patients: A One-year Follow-up Study , 2014, Tremor and other hyperkinetic movements.

[165]  Sebastiaan Overeem,et al.  Actigraphy as a diagnostic aid for REM sleep behavior disorder in Parkinson’s disease , 2014, BMC Neurology.

[166]  G. Stebbins,et al.  Beyond a motor disorder: a prospective evaluation of sleep quality in cervical dystonia. , 2014, Parkinsonism & related disorders.

[167]  N. Brüggemann,et al.  Non-motor phenotype of dopa-responsive dystonia and quality of life assessment. , 2014, Parkinsonism & related disorders.

[168]  C. Baumann,et al.  Revisiting the impact of REM sleep behavior disorder on motor progression in Parkinson's disease. , 2014, Parkinsonism & related disorders.

[169]  A. Rademaker,et al.  Circadian melatonin rhythm and excessive daytime sleepiness in Parkinson disease. , 2014, JAMA neurology.

[170]  B. Mollenhauer,et al.  Rapid eye movement sleep behavioral events: a new marker for neurodegeneration in early Parkinson disease? , 2014, Sleep.

[171]  Poul Jennum,et al.  Decreased sleep spindle density in patients with idiopathic REM sleep behavior disorder and patients with Parkinson’s disease , 2014, Clinical Neurophysiology.

[172]  J R Hodges,et al.  Disturbances in melatonin secretion and circadian sleep-wake regulation in Parkinson disease. , 2014, Sleep medicine.

[173]  J. Molinuevo,et al.  Neurodegenerative Disorder Risk in Idiopathic REM Sleep Behavior Disorder: Study in 174 Patients , 2014, PloS one.

[174]  D. Burn,et al.  Primary sleep disorder prevalence in patients with newly diagnosed Parkinson's disease , 2014, Movement disorders : official journal of the Movement Disorder Society.

[175]  Xiao-Min Wang,et al.  Sleep Disorders in Parkinson’s Disease: Clinical Features, Iron Metabolism and Related Mechanism , 2013, PloS one.

[176]  H. Tan,et al.  Restless Legs Syndrome and Its Associated Risk Factors in Parkinson's Disease , 2013, Parkinson's disease.

[177]  A. Mansour,et al.  Clinical and polysomnographic study of RBD in Parkinson’s disease from Egypt , 2013 .

[178]  S. Ancoli-Israel,et al.  Effects of sleep disorders on the non-motor symptoms of Parkinson disease. , 2013, Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.

[179]  R. Chervin,et al.  Insomnia and sleepiness in Parkinson disease: associations with symptoms and comorbidities. , 2013, Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.

[180]  C. Shapiro,et al.  Relationship Between Polysomnographic Sleep Architecture and Behavior in Medication-free Children with TS, ADHD, TS and ADHD, and Controls , 2013, Journal of developmental and behavioral pediatrics : JDBP.

[181]  J. Benito-León,et al.  Short sleep duration heralds essential tremor: A prospective, population‐based study , 2013, Movement disorders : official journal of the Movement Disorder Society.

[182]  P. Derambure,et al.  Rapid eye movement sleep behavior disorder in treatment-naïve Parkinson disease patients. , 2013, Sleep medicine.

[183]  C. Baumann,et al.  Sleepwalking, REM Sleep Behaviour Disorder and Overlap Parasomnia in Patients with Parkinson's Disease , 2013, European Neurology.

[184]  E. Sinforiani,et al.  Analysis of video‐polysomnographic sleep findings in dementia with Lewy bodies , 2013, Movement disorders : official journal of the Movement Disorder Society.

[185]  S. Lewis,et al.  The Relationship between Thermoregulation and REM Sleep Behaviour Disorder in Parkinson’s Disease , 2013, PloS one.

[186]  Alexandra Durr,et al.  Biological and clinical characteristics of individuals at risk for spinocerebellar ataxia types 1, 2, 3, and 6 in the longitudinal RISCA study: analysis of baseline data , 2013, The Lancet Neurology.

[187]  Habib Benali,et al.  The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson’s disease , 2013, Brain : a journal of neurology.

[188]  M. Alegre,et al.  Cardiac autonomic impairment during sleep is linked with disease severity in Parkinson’s disease , 2013, Clinical Neurophysiology.

[189]  Wei Song,et al.  Clinical and polysomnographic features of patients with multiple system atrophy in Southwest China , 2013, Sleep and Breathing.

[190]  Sandro Sorbi,et al.  Daytime course of sleepiness in de novo Parkinson's disease patients , 2013, Journal of sleep research.

[191]  U. Muthane,et al.  Prevalence and profile of Restless Legs Syndrome in Parkinson's disease and other neurodegenerative disorders: a case-control study. , 2013, Parkinsonism & related disorders.

[192]  C. Trenkwalder,et al.  No Difference in Sleep and RBD between Different Types of Patients with Multiple System Atrophy: A Pilot Video-Polysomnographical Study , 2013, Sleep disorders.

[193]  C. Baumann,et al.  REM sleep behavior disorder in Parkinson's disease: a questionnaire-based survey. , 2013, Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.

[194]  R. Petersen,et al.  Polysomnographic Findings in Dementia With Lewy Bodies , 2013, The neurologist.

[195]  Hsiao-Lun Ku,et al.  Sleep disruption in spinocerebellar ataxia type 3: A genetic and polysomnographic study , 2013, Journal of the Chinese Medical Association : JCMA.

[196]  N. Diederich,et al.  Lack of Polysomnographic Non-REM Sleep Changes in Early Parkinson’s Disease , 2013, Movement disorders : official journal of the Movement Disorder Society.

[197]  Y. Ouchi,et al.  The high frequency of periodic limb movements in patients with Lewy body dementia. , 2012, Journal of psychiatric research.

[198]  M. Weller,et al.  Progressive dopamine and hypocretin deficiencies in Parkinson’s disease: is there an impact on sleep and wakefulness? , 2012, Journal of sleep research.

[199]  T. Shimohata,et al.  Daytime sleepiness in Japanese patients with multiple system atrophy: prevalence and determinants , 2012, BMC Neurology.

[200]  B. Högl,et al.  L01 Sleep in patients with huntington's disease: an interim analysis , 2012, Journal of Neurology, Neurosurgery & Psychiatry.

[201]  B. Sivertsen,et al.  Sleep problems in Parkinson's disease: a community-based study in Norway , 2012, BMC Neurology.

[202]  R. Manni,et al.  REM and NREM sleep enactment behaviors in Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies. , 2012, Sleep medicine.

[203]  K. Hirata,et al.  Nocturnal disturbances and restlessness in Parkinson's disease: Using the Japanese version of the Parkinson's disease sleep scale-2 , 2012, Journal of the Neurological Sciences.

[204]  Véronique Latreille,et al.  Rapid eye movement sleep behavior disorder and subtypes of Parkinson's disease , 2012, Movement disorders : official journal of the Movement Disorder Society.

[205]  G. Plazzi,et al.  A preliminary quantitative analysis of REM sleep chin EMG in Parkinson's disease with or without REM sleep behavior disorder. , 2012, Sleep medicine.

[206]  S. Ancoli-Israel,et al.  Clinical correlates of periodic limb movements in sleep in Parkinson's disease , 2012, Journal of the Neurological Sciences.

[207]  K. Nakashima,et al.  Comparison of REM sleep behaviour disorder variables between patients with progressive supranuclear palsy and those with Parkinson's disease. , 2012, Parkinsonism & related disorders.

[208]  P. Pal,et al.  Non‐motor features in essential tremor , 2012, Acta neurologica Scandinavica.

[209]  E. Louis,et al.  Sleep in essential tremor: a comparison with normal controls and Parkinson's disease patients. , 2012, Parkinsonism & related disorders.

[210]  J. Larsen,et al.  Increased risk of leg motor restlessness but not RLS in early Parkinson disease , 2011, Neurology.

[211]  B. Mollenhauer,et al.  Associated factors for REM sleep behavior disorder in Parkinson disease , 2011, Neurology.

[212]  R. Chervin,et al.  Risk of sleep-disordered breathing in Parkinson's disease , 2011, Sleep and Breathing.

[213]  E. Tan,et al.  Case Control Polysomnographic Studies of Sleep Disorders in Parkinson's Disease , 2011, PloS one.

[214]  H. Shill,et al.  Probable RBD is increased in Parkinson's disease but not in essential tremor or restless legs syndrome. , 2011, Parkinsonism & related disorders.

[215]  E. Růžička,et al.  Sleep disturbances in untreated Parkinson’s disease , 2011, Journal of Neurology.

[216]  A. Ormazabal,et al.  Neuropsychiatric symptoms and intelligence quotient in autosomal dominant Segawa disease , 2011, Journal of Neurology.

[217]  M. Farrer,et al.  A family with parkinsonism, essential tremor, restless legs syndrome, and depression , 2011, Neurology.

[218]  A. Spottke,et al.  Impaired sleep quality and restless legs syndrome in idiopathic focal dystonia: a controlled study , 2011, Journal of Neurology.

[219]  R. Rodríguez-Labrada,et al.  Sleep Disorders in Spinocerebellar Ataxia Type 2 Patients , 2011, Neurodegenerative Diseases.

[220]  R. Barker,et al.  Asymptomatic Sleep Abnormalities Are a Common Early Feature in Patients with Huntington’s Disease , 2011, Current neurology and neuroscience reports.

[221]  G. Deuschl,et al.  Effect of controlled‐release levodopa on the microstructure of sleep in Parkinson’s disease , 2011, European journal of neurology.

[222]  K. Nakashima,et al.  Comparison of the clinical features of rapid eye movement sleep behavior disorder in patients with Parkinson's disease and multiple system atrophy , 2011, Psychiatry and clinical neurosciences.

[223]  B. Boeve,et al.  Sleep Disturbance in Dementia with Lewy Bodies and Alzheimer’s Disease: A Multicenter Analysis , 2011, Dementia and Geriatric Cognitive Disorders.

[224]  James Robert Brašić,et al.  The dopamine transporter is decreased in the striatum of subjects with restless legs syndrome. , 2011, Sleep.

[225]  M. Vidailhet,et al.  The improvement of movement and speech during rapid eye movement sleep behaviour disorder in multiple system atrophy. , 2011, Brain : a journal of neurology.

[226]  L. Chahine,et al.  Effects of STN DBS for Parkinson's disease on restless legs syndrome and other sleep-related measures. , 2011, Parkinsonism & related disorders.

[227]  C. Bassetti,et al.  Sleepwalking in Parkinson’s disease: a questionnaire-based survey , 2011, Journal of Neurology.

[228]  G. Prado,et al.  Sleep Disorders in Machado–Joseph Disease: Frequency, Discriminative Thresholds, Predictive Values, and Correlation with Ataxia-Related Motor and Non-Motor Features , 2011, The Cerebellum.

[229]  T. Yuasa,et al.  Progressive supranuclear palsy presenting with urinary retention and sleep apnea , 2011, Clinical Autonomic Research.

[230]  S. Nevsimalova,et al.  Sleep disorders in Wilson’s disease , 2011, European journal of neurology.

[231]  D. Waldvogel,et al.  Fatigue and excessive daytime sleepiness in idiopathic Parkinson’s disease differently correlate with motor symptoms, depression and dopaminergic treatment , 2010, European journal of neurology.

[232]  D. Kunz,et al.  A two‐part, double‐blind, placebo‐controlled trial of exogenous melatonin in REM sleep behaviour disorder , 2010, Journal of sleep research.

[233]  D. Brooks,et al.  Faculty Opinions recommendation of Decreased striatal dopamine transporter uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study [corrected]. , 2010 .

[234]  J. Molinuevo,et al.  Decreased striatal dopamine transporter uptake and substantia nigra hyperechogenicity as risk markers of synucleinopathy in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a prospective study , 2010, The Lancet Neurology.

[235]  A. Taly,et al.  Sleep in Wilson's disease: a polysomnography-based study. , 2010, Neurology India.

[236]  S. V. van Rooden,et al.  Prevalence and clinical profile of restless legs syndrome in Parkinson's disease , 2010, Movement disorders : official journal of the Movement Disorder Society.

[237]  R. Barker,et al.  Identifying sleep disturbances in Huntington’s disease using a simple disease-focused questionnaire , 2010, PLoS currents.

[238]  Winfried Ilg,et al.  No increased risk of obstructive sleep apnea in Parkinson's disease , 2010, Movement disorders : official journal of the Movement Disorder Society.

[239]  R. Roos,et al.  Sleep and circadian rhythm alterations correlate with depression and cognitive impairment in Huntington's disease. , 2010, Parkinsonism & related disorders.

[240]  P. F. D. de Bruin,et al.  Sleep disturbances and brain MRI morphometry in Parkinson's disease, multiple system atrophy and progressive supranuclear palsy - a comparative study. , 2010, Parkinsonism & related disorders.

[241]  A. Cronin-Golomb,et al.  Sleep in Parkinson's disease: a comparison of actigraphy and subjective measures. , 2010, Parkinsonism & related disorders.

[242]  R. Sothern,et al.  Expression of clock genes Per1 and Bmal1 in total leukocytes in health and Parkinson’s disease , 2010, European journal of neurology.

[243]  D. Martino,et al.  Quality of sleep in primary focal dystonia: a case–control study , 2010, European journal of neurology.

[244]  D. Cunnington,et al.  Excessive daytime somnolence in spinocerebellar ataxia type 1 , 2010, Journal of the Neurological Sciences.

[245]  M. Vidailhet,et al.  Is obstructive sleep apnea a problem in Parkinson's disease? , 2010, Sleep medicine.

[246]  Masaaki Suzuki,et al.  Multiple system atrophy manifesting as complex sleep-disordered breathing. , 2010, Auris, nasus, larynx.

[247]  S. Factor,et al.  Excessive daytime sleepiness in cervical dystonia. , 2009, Parkinsonism & related disorders.

[248]  M. I. Norlinah,et al.  Sleep disturbances in Malaysian patients with Parkinson's disease using polysomnography and PDSS. , 2009, Parkinsonism & related disorders.

[249]  R. Abramson,et al.  Sleep Patterns in Patients With Huntington's Disease and Their Unaffected First-Degree Relatives: A Brief Report , 2009, Behavioral sleep medicine.

[250]  M. Cendoroglo,et al.  Fatigue in a cohort of geriatric patients with and without Parkinson's disease. , 2009, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[251]  R. Wennberg,et al.  Selective enhancement of rapid eye movement sleep by deep brain stimulation of the human pons , 2009, Annals of neurology.

[252]  S. Leurgans,et al.  Daytime somnolence and nocturnal sleep disturbances in Huntington disease. , 2009, Parkinsonism & related disorders.

[253]  E. Storch,et al.  Sleep-Related Problems in Youth with Tourette's Syndrome and Chronic Tic Disorder , 2009 .

[254]  Brit Mollenhauer,et al.  Polysomnographic findings, video-based sleep analysis and sleep perception in progressive supranuclear palsy. , 2009, Sleep medicine.

[255]  P. Burkhard,et al.  Restless legs syndrome: an early manifestation of Huntington’s disease? , 2009, Acta neurologica Scandinavica.

[256]  Y. Sohn,et al.  Factors contributing to the development of restless legs syndrome in patients with Parkinson disease , 2009, Movement disorders : official journal of the Movement Disorder Society.

[257]  A. Negrotti,et al.  Absence of co-morbidity of Parkinson disease and restless legs syndrome: a case–control study in patients attending a movement disorders clinic , 2009, Neurological Sciences.

[258]  G. Plazzi,et al.  Status dissociatus evolving from REM sleep behaviour disorder in multiple system atrophy. , 2009, Sleep medicine.

[259]  Nobutaka Hattori,et al.  Parkinson’s Disease with and without REM Sleep Behaviour Disorder: Are There Any Clinical Differences? , 2009, European Neurology.

[260]  P. Pasqualetti,et al.  Sleep-wake cycle and effects of cabergoline monotherapy in de novo Parkinson’s disease patients , 2008, Journal of Neurology.

[261]  S. Leurgans,et al.  Visual hallucinations and symptoms of REM sleep behavior disorder in Parkinsonian tauopathies , 2008, International journal of geriatric psychiatry.

[262]  J. Schiefer,et al.  Rapid eye movement sleep disturbances in Huntington disease. , 2008, Archives of neurology.

[263]  E. Tan,et al.  Case–control study of restless legs syndrome and quality of sleep in Parkinson's disease , 2008, Journal of the Neurological Sciences.

[264]  H. Hjalgrim,et al.  Validation of the Presence of Comorbidities in a Danish Clinical Cohort of Children With Tourette Syndrome , 2008, Journal of child neurology.

[265]  J. Marinus,et al.  Nighttime sleep problems and daytime sleepiness in Parkinson's disease , 2008, Movement disorders : official journal of the Movement Disorder Society.

[266]  R. Walker,et al.  The frequency and nature of sleep disorders in a community‐based population of patients with Parkinson’s disease , 2007, European journal of neurology.

[267]  G. Plazzi,et al.  Impaired cortical and autonomic arousal during sleep in multiple system atrophy , 2007, Clinical Neurophysiology.

[268]  Mandar S Jog,et al.  Methylphenidate improves fatigue scores in Parkinson disease: A randomized controlled trial , 2007, Movement disorders : official journal of the Movement Disorder Society.

[269]  E. Tolosa,et al.  Cerebrospinal fluid hypocretin‐1 levels in multiple system atrophy , 2007, Movement disorders : official journal of the Movement Disorder Society.

[270]  P. Derambure,et al.  Sleep and vigilance in corticobasal degeneration: A descriptive study , 2007, Neurophysiologie Clinique/Clinical Neurophysiology.

[271]  K. Hirata,et al.  Characteristics of sleep disturbances in Japanese patients with Parkinson's disease. A study using Parkinson's disease sleep scale , 2007, Movement disorders : official journal of the Movement Disorder Society.

[272]  E. Tolosa,et al.  Efficacy of pramipexole and transdermal rotigotine in advanced Parkinson's disease: a double-blind, double-dummy, randomised controlled trial , 2007, The Lancet Neurology.

[273]  T. Banaschewski,et al.  Sleep patterns in children with attention-deficit/hyperactivity disorder, tic disorder, and comorbidity. , 2007, Journal of child psychology and psychiatry, and allied disciplines.

[274]  Tetsutaro Ozawa,et al.  Daytime hypoxemia, sleep-disordered breathing, and laryngopharyngeal findings in multiple system atrophy. , 2007, Archives of neurology.

[275]  I. McKeith,et al.  Subjectively reported sleep quality and excessive daytime somnolence in Parkinson's disease with and without dementia, dementia with Lewy bodies and Alzheimer's disease , 2007, International journal of geriatric psychiatry.

[276]  T. Banaschewski,et al.  REM-sleep alterations in children with co-existence of tic disorders and attention-deficit/hyperactivity disorder: impact of hypermotor symptoms , 2007, European Child & Adolescent Psychiatry.

[277]  Michael S Okun,et al.  Depression symptoms in movement disorders: Comparing Parkinson's disease, dystonia, and essential tremor , 2007, Movement disorders : official journal of the Movement Disorder Society.

[278]  G. Plazzi,et al.  Sleep‐related stridor due to dystonic vocal cord motion and neurogenic tachypnea/tachycardia in multiple system atrophy , 2007, Movement disorders : official journal of the Movement Disorder Society.

[279]  F. Pasquier,et al.  Efficacy and Safety of Galantamine in Patients with Dementia with Lewy Bodies: A 24-Week Open-Label Study , 2007, Dementia and Geriatric Cognitive Disorders.

[280]  K. Krakow,et al.  Stages of sleep pathology in spinocerebellar ataxia type 2 (SCA2) , 2006, Neurology.

[281]  K. Nakashima,et al.  CSF orexin levels of Parkinson's disease, dementia with Lewy bodies, progressive supranuclear palsy and corticobasal degeneration , 2006, Journal of the Neurological Sciences.

[282]  D. Aarsland,et al.  Insomnia in Parkinson’s disease: frequency and progression over time , 2006, Journal of Neurology, Neurosurgery & Psychiatry.

[283]  K. Ray Chaudhuri,et al.  The range and nature of sleep dysfunction in untreated Parkinson's disease (PD). A comparative controlled clinical study using the Parkinson's disease sleep scale and selective polysomnography , 2006, Journal of the Neurological Sciences.

[284]  W. Poewe,et al.  Disturbance of rapid eye movement sleep in spinocerebellar ataxia type 2 , 2006, Movement disorders : official journal of the Movement Disorder Society.

[285]  L. Pollak,et al.  Excessive daytime sleepiness in patients with Parkinson's disease: A polysomnography study , 2006, Movement disorders : official journal of the Movement Disorder Society.

[286]  P. Derambure,et al.  Vigilance troubles in Parkinson's disease: a subjective and objective polysomnographic study. , 2006, Sleep medicine.

[287]  J. Zarranz,et al.  Sleep complaints and their relation with drug treatment in patients suffering from Parkinson's disease , 2006, Movement disorders : official journal of the Movement Disorder Society.

[288]  M. Mahowald,et al.  Evaluation of sleep and daytime somnolence in spinocerebellar ataxia type 6 (SCA6) , 2006, Neurology.

[289]  W. Ondo,et al.  Association between restless legs syndrome and essential tremor , 2006, Movement disorders : official journal of the Movement Disorder Society.

[290]  K. Nakashima,et al.  Prevalence and clinical characteristics of restless legs syndrome in Japanese patients with Parkinson's disease , 2006, Movement disorders : official journal of the Movement Disorder Society.

[291]  O. Rascol,et al.  Sleep disruption, daytime somnolence and ‘sleep attacks’ in Parkinson's disease: a clinical survey in PD patients and age‐matched healthy volunteers , 2006, European journal of neurology.

[292]  J. Steyaert,et al.  Expanded motor and psychiatric phenotype in autosomal dominant Segawa syndrome due to GTP cyclohydrolase deficiency , 2005, Journal of Neurology, Neurosurgery & Psychiatry.

[293]  N. Diederich,et al.  Sleep apnea syndrome in Parkinson's disease. A case–control study in 49 patients , 2005, Movement disorders : official journal of the Movement Disorder Society.

[294]  L. Saccomani,et al.  Tourette syndrome and chronic tics in a sample of children and adolescents , 2005, Brain and Development.

[295]  E. Tolosa,et al.  Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD , 2005, Neurology.

[296]  K. Abe,et al.  Sleep disturbances in Japanese patients with Parkinson's disease—comparing with patients in the UK , 2005, Journal of the Neurological Sciences.

[297]  B. Bioulac,et al.  Unusual nocturnal motor restlessness in a patient with spinocerebellar ataxia 3 , 2005, Movement disorders : official journal of the Movement Disorder Society.

[298]  B. Bioulac,et al.  Continuous positive airway pressure for sleep-related breathing disorders in multiple system atrophy: long-term acceptance. , 2005, Sleep medicine.

[299]  M. Kryger,et al.  Long-term treatment of sleep breathing disorder in a patient with Huntington's disease. , 2005, Parkinsonism & related disorders.

[300]  C. Comella,et al.  Nocturnal activity with nighttime pergolide in Parkinson disease: A controlled study using actigraphy , 2005, Neurology.

[301]  J. Röschke,et al.  Perception of sleep: Subjective versus objective sleep parameters in patients with Parkinson’s disease in comparison with healthy elderly controls , 2005, Journal of Neurology.

[302]  S. Lewis,et al.  The use of the Actiwatch–Neurologica® system to objectively assess the involuntary movements and sleep–wake activity in patients with mild–moderate Huntington’s disease , 2005, Journal of Neurology.

[303]  Y. Agid,et al.  REM sleep behavior disorder and REM sleep without atonia in patients with progressive supranuclear palsy. , 2005, Sleep.

[304]  G. Plazzi,et al.  REM sleep behaviour disorder in Parkinson’s disease: a questionnaire-based study , 2005, Neurological Sciences.

[305]  R. Barker,et al.  Disintegration of the Sleep-Wake Cycle and Circadian Timing in Huntington's Disease , 2005, The Journal of Neuroscience.

[306]  P. Anderer,et al.  Sleep microstructure and neurodegeneration as measured by [123I]β-CIT SPECT in treated patients with Parkinson’s disease , 2004, Journal of Neurology.

[307]  F. Richer,et al.  Restless legs in Tourette syndrome , 2004, Movement disorders : official journal of the Movement Disorder Society.

[308]  D. Comings,et al.  Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity , 2004, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[309]  R. Howard,et al.  Multiple system atrophy presenting as central sleep apnoea , 2004, European Respiratory Journal.

[310]  N. Tachibana,et al.  Longitudinal change in REM sleep components in a patient with multiple system atrophy associated with REM sleep behavior disorder: paradoxical improvement of nocturnal behaviors in a progressive neurodegenerative disease. , 2004, Sleep medicine.

[311]  K. Thennarasu,et al.  Nocturnal sleep disturbances and daytime dysfunction in patients with Parkinson's disease and in their caregivers. , 2004, Parkinsonism & related disorders.

[312]  J. Carrier,et al.  Association between waking EEG slowing and REM sleep behavior disorder in PD without dementia , 2004, Neurology.

[313]  P. Bruin,et al.  Snoring and excessive daytime sleepiness in Parkinson's disease , 2004, Journal of the Neurological Sciences.

[314]  A. Walters,et al.  A preliminary look at the percentage of patients with Restless Legs Syndrome who also have Parkinson Disease, Essential Tremor or Tourette Syndrome in a single practice , 2003, Journal of sleep research.

[315]  J. Friedman,et al.  REM behavior disorder and excessive daytime somnolence in Machado–Joseph disease (SCA‐3) , 2003, Movement disorders : official journal of the Movement Disorder Society.

[316]  J. Sharma,et al.  SLEEP DISORDERS IN PARKINSON'S DISEASE , 2003, International journal of clinical practice.

[317]  M. Michalis,et al.  Sleep breathing disorders in patients with idiopathic Parkinson's disease. , 2003, Respiratory medicine.

[318]  E. Rüther,et al.  Disturbed sleep in children with Tourette syndrome: a polysomnographic study. , 2003, Journal of psychosomatic research.

[319]  Donald L Bliwise,et al.  Assessment of sleepiness and unintended sleep in Parkinson's disease patients taking dopamine agonists. , 2003, Sleep medicine.

[320]  E. Mignot,et al.  Sleep disturbances and hypocretin deficiency in Niemann-Pick disease type C. , 2003, Sleep.

[321]  W. Poewe,et al.  Increased daytime sleepiness in Parkinson's disease: A questionnaire survey , 2003, Movement disorders : official journal of the Movement Disorder Society.

[322]  S. Evers,et al.  Genetic association of Huntington's disease and restless legs syndrome? A family report , 2003, Movement disorders : official journal of the Movement Disorder Society.

[323]  G. Fabbrini,et al.  Excessive daytime sleepiness in de novo and treated Parkinson's disease , 2002, Movement disorders : official journal of the Movement Disorder Society.

[324]  C. Trenkwalder,et al.  Microstructure of the non‐rapid eye movement sleep electroencephalogram in patients with newly diagnosed Parkinson's disease: Effects of dopaminergic treatment , 2002, Movement disorders : official journal of the Movement Disorder Society.

[325]  J. Carrier,et al.  REM sleep behavior disorder and REM sleep without atonia in Parkinson’s disease , 2002, Neurology.

[326]  P. Holmes,et al.  Comparison of sleep disturbance in mild versus severe Parkinson's disease. , 2002, Sleep.

[327]  B. Bioulac,et al.  Sleep disorders and their determinants in multiple system atrophy , 2002, Journal of neurology, neurosurgery, and psychiatry.

[328]  D. Aarsland,et al.  Development of daytime somnolence over time in Parkinson’s disease , 2002, Neurology.

[329]  Y. Agid,et al.  Parkinson’s disease and sleepiness: An integral part of PD , 2002, Neurology.

[330]  A. Lang,et al.  Excessive daytime sleepiness and sudden-onset sleep in Parkinson disease: a survey by the Canadian Movement Disorders Group. , 2002, JAMA.

[331]  I. Kanazawa,et al.  Homozygous Machado–Joseph disease presenting as REM sleep behaviour disorder and prominent psychiatric symptoms , 2002, European journal of neurology.

[332]  J. Broman,et al.  Sleep in patients with treated Wilson's disease. A questionnaire study , 2002, Nordic journal of psychiatry.

[333]  A. Monaco,et al.  McLeod neuroacanthocytosis: Genotype and phenotype , 2001, Annals of neurology.

[334]  M. Alegre,et al.  Unilateral periodic limb movements during sleep in corticobasal degeneration , 2001, Movement disorders : official journal of the Movement Disorder Society.

[335]  W. Martin,et al.  Daytime somnolence in patients with Parkinson's disease. , 2001, Parkinsonism & related disorders.

[336]  T. Wetter,et al.  Increased alpha activity in REM sleep in de novo patients with Parkinson's disease , 2001, Movement disorders : official journal of the Movement Disorder Society.

[337]  L. Werneck,et al.  Tics and Tourette syndrome: clinical evaluation of 44 cases. , 2001, Arquivos de neuro-psiquiatria.

[338]  G. Ebersbach,et al.  Sudden daytime sleep onset in Parkinson's disease: Polysomnographic recordings , 2001, Movement disorders : official journal of the Movement Disorder Society.

[339]  S. Noachtar,et al.  REM sleep behavior disorder in sleep-disordered patients with versus without Parkinson's disease: is there a need for polysomnography? , 2001, Journal of the Neurological Sciences.

[340]  J. Dichgans,et al.  Restless legs syndrome in spinocerebellar ataxia types 1, 2, and 3 , 2001, Journal of Neurology.

[341]  E. Rüther,et al.  Decreased sleep quality and increased sleep related movements in patients with Tourette's syndrome , 2001, Journal of neurology, neurosurgery, and psychiatry.

[342]  I. McKeith,et al.  A comparison of sleep profiles in patients with dementia with Lewy bodies and Alzheimer's disease , 2000, International journal of geriatric psychiatry.

[343]  E. Tolosa,et al.  Continuous positive air pressure eliminates nocturnal stridor in multiple system atrophy , 2000, The Lancet.

[344]  M. Silber,et al.  Stridor and death in multiple system atrophy , 2000, Movement disorders : official journal of the Movement Disorder Society.

[345]  Paul Sandor,et al.  An international perspective on Tourette syndrome: selected findings from 3500 individuals in 22 countries , 2000, Developmental medicine and child neurology.

[346]  T. Wetter,et al.  Sleep and periodic leg movement patterns in drug-free patients with Parkinson's disease and multiple system atrophy. , 2000, Sleep.

[347]  P. Halász,et al.  Hypersomnia in Wilson's disease: an unusual symptom in an unusual case. , 2000, Acta neurologica Scandinavica.

[348]  B. Boeve,et al.  Rapid eye movement sleep behaviour disorder: demographic, clinical and laboratory findings in 93 cases. , 2000, Brain : a journal of neurology.

[349]  J. Larsen,et al.  Excessive daytime sleepiness and sleep benefit in Parkinson's disease: A community‐based study , 1999, Movement disorders : official journal of the Movement Disorder Society.

[350]  S. Gauthier,et al.  Sleep and quantitative EEG in patients with progressive supranuclear palsy , 1997, Neurology.

[351]  N. Taylor,et al.  Sleep disturbance and Huntingdon's disease , 1997, British Journal of Psychiatry.

[352]  A. Straube,et al.  Periodic limb movements during sleep are a frequent finding in patients with Gilles de la Tourette’s syndrome , 1997, Journal of Neurology.

[353]  G. Sethuraman,et al.  Dopamine agonist treatment of tourette disorder in children: Results of an open‐label trial of pergolide , 1997, Movement disorders : official journal of the Movement Disorder Society.

[354]  G. Plazzi,et al.  REM sleep behavior disorders in multiple system atrophy , 1997, Neurology.

[355]  W. Oertel,et al.  Sleep Disturbances in Parkinson's Disease Patients and Spouses , 1997, Journal of the American Geriatrics Society.

[356]  F. Lobbezoo,et al.  Relationship Between Sleep, Neck Muscle Activity, and Pain in Cervical Dystonia , 1996, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[357]  T. Sadaoka,et al.  Sleep-related breathing disorders in patients with multiple system atrophy and vocal fold palsy. , 1996, Sleep.

[358]  R. Howard,et al.  Nocturnal and respiratory disturbances in Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy). , 1996, Postgraduate medical journal.

[359]  K. Hirata,et al.  Sleep disturbances in Huntington disease and DRPLA , 1996 .

[360]  A. Tisano,et al.  Sleep features in Tourette's syndrome, neuroacanthocytosis and Huntington's chorea , 1995, Neurophysiologie Clinique/Clinical Neurophysiology.

[361]  N. Quinn,et al.  REM sleep behaviour disorder as the presenting symptom of multiple system atrophy. , 1995, Journal of neurology, neurosurgery, and psychiatry.

[362]  P. Furer,et al.  Tourette syndrome: Associated symptoms and most disabling features , 1993, Neuroscience & Biobehavioral Reviews.

[363]  R. Manni,et al.  Nocturnal sleep in multisystem atrophy with autonomic failure: polygraphic findings in ten patients , 1993, Journal of Neurology.

[364]  H. Singer,et al.  Sleep disorders in Tourette syndrome: a primary or unrelated problem? , 1992, Pediatric neurology.

[365]  J. Krieg,et al.  Sleep EEG in Gilles de la Tourette's syndrome , 1992, Journal of Neurology.

[366]  E. Sforza,et al.  Sleep and cranial dystonia. , 1991, Electroencephalography and clinical neurophysiology.

[367]  M. Dose,et al.  Nocturnal sleep in huntington's disease , 1991, Journal of Neurology.

[368]  J. Jankovic,et al.  Cervical dystonia , 1991, Neurology.

[369]  C. Marsden,et al.  The effect of sleep on the dyskinetic movements of Parkinson's disease, Gilles de la Tourette syndrome, Huntington's disease, and torsion dystonia. , 1991, Archives of neurology.

[370]  C. Marsden,et al.  Motor inhibition from the brainstem is normal in torsion dystonia during REM sleep. , 1991, Journal of neurology, neurosurgery, and psychiatry.

[371]  Sing Lee The Neuropsychiatric Evolution of a Case of Progressive Supranuclear Palsy , 1991, British Journal of Psychiatry.

[372]  C. Marsden,et al.  Sleep spindles in torsion dystonia. , 1990, Archives of neurology.

[373]  P. Lavie,et al.  Motor abnormalities during sleep in patients with childhood hereditary progressive dystonia, and their unaffected family members. , 1989, Sleep.

[374]  D. Comings,et al.  A controlled study of Tourette syndrome. VI. Early development, sleep problems, allergies, and handedness. , 1987, American journal of human genetics.

[375]  J. Jankovic,et al.  Motor, Behavioral and Pharmacologic Findings in Tourette's Syndrome , 1987, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[376]  J. Friedman,et al.  Respiration and sleep in Parkinson's disease. , 1986, Journal of neurology, neurosurgery, and psychiatry.

[377]  E. Niedermeyer,et al.  Polysomnography of torsion dystonia. , 1984, Archives of neurology.

[378]  W. Matthews,et al.  SOMNAMBULISM IN CHILDREN WITH TOURETTE SYNDROME , 1984, Developmental medicine and child neurology.

[379]  J. Frost,et al.  Effect of tetrabenazine on tics and sleep of Gilles de la Tourette's syndrome , 1984, Neurology.

[380]  E. Niedermeyer,et al.  Polysomnographic findings in dystonia musculorum deformans. , 1983, Sleep.

[381]  T. Hashimoto,et al.  Increased body movements during sleep in gilles de la tourette syndrome , 1981, Brain and Development.

[382]  E. Jones Disease , 2020, Palgrave Studies in Economic History.

[383]  Jean-Pierre Lin,et al.  Gabapentin can significantly improve dystonia severity and quality of life in children. , 2016, European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society.

[384]  F. Sedel,et al.  [Psychiatric disorders in adult form of Niemann-Pick disease type C]. , 2016, L'Encephale.

[385]  Huidong Tang,et al.  Prevalence and clinical features of non-motor symptoms of essential tremor in Shanghai rural area. , 2016, Parkinsonism & related disorders.

[386]  M. Goldoni,et al.  A prospective study of the cumulative incidence and course of restless legs syndrome in de novo patients with Parkinson’s disease during chronic dopaminergic therapy , 2015, Journal of Neurology.

[387]  R. Rijsman,et al.  Restless legs syndrome in Parkinson's disease. , 2014, Parkinsonism & related disorders.

[388]  G. B. Zimatore,et al.  Do non-motor symptoms in Parkinson's disease differ from essential tremor before initial diagnosis? A clinical and scintigraphic study. , 2014, Parkinsonism & related disorders.

[389]  R. Riha,et al.  Beta-blockers as a cause of violent rapid eye movement sleep behavior disorder: a poorly recognized but common cause of violent parasomnias. , 2011, The American journal of medicine.

[390]  A. Taly,et al.  Sleep in Wilson’s disease: Questionnaire based study , 2011, Annals of Indian Academy of Neurology.

[391]  K. Josephs,et al.  Photophobia, visual hallucinations, and REM sleep behavior disorder in progressive supranuclear palsy and corticobasal degeneration: a prospective study. , 2009, Parkinsonism & related disorders.

[392]  W. Koroshetz,et al.  Quetiapine in the treatment of behavioral disturbances in patients with Huntington's disease. , 2006, Psychosomatics.

[393]  Wolfgang Schreiber,et al.  Brain morphology and sleep EEG in patients with Huntington's disease , 2005, European Archives of Psychiatry and Clinical Neuroscience.

[394]  D. Waldvogel,et al.  Parkinsonism with excessive daytime sleepiness--a narcolepsy-like disorder? , 2005, Journal of neurology.

[395]  K. Schimrigk,et al.  Changes in nocturnal sleep in Huntington's and Parkinson's disease , 2004, Journal of Neurology.

[396]  G. Plazzi,et al.  Sleep disorders in multiple system atrophy: a correlative video-polysomnographic study. , 2004, Sleep medicine.

[397]  D. Licht,et al.  Juvenile dentatorubral-pallidoluysian atrophy: new clinical features. , 2002, Pediatric neurology.

[398]  P. Bramanti,et al.  The effect of nocturnal physiological sleep on various movement disorders , 1990, Movement disorders : official journal of the Movement Disorder Society.

[399]  Roberta F. White,et al.  Sleep Abnormdties in Progressive Suprmuclear Palsy , 1989 .