Quantification of multiple bioagents with wireless, remote-query magnetoelastic microsensors

This paper presents a micromagnetoelastic sensor array for simultaneously monitoring multiple biological agents. Magnetoelastic sensors, made of low-cost amorphous ferromagnetic ribbons, are analogous and complementary to piezoelectric acoustic wave sensors, which track parameters of interest via changes in resonance behavior. Magnetoelastic sensors are excited with magnetic ac fields, and, in turn, they generate magnetic fluxes that can be detected with a sensing coil from a distance. As a result, these sensors are highly attractive, not only due to their small size and low cost, but also because of their passive and wireless nature. Magnetoelastic sensors have been applied for monitoring pressure, temperature, liquid density, and viscosity, fluid How velocity and direction, and with chemical/biological responsive coatings that change mass or elasticity, various biological and chemical agents. In this paper, we report the fabrication and application of a six-sensor array for simultaneous measurement of Escherichia coli O157:H7, staphylococcal enterotoxin B, and ricin. In addition, the sensor array also monitors temperature and pH so the measurements are independent from these two parameters

[1]  C A Grimes,et al.  A wireless, remote query magnetoelastic CO2 sensor. , 2000, Journal of environmental monitoring : JEM.

[2]  C A Grimes,et al.  A wireless, remote query ammonia sensor. , 2001, Sensors and actuators. B, Chemical.

[3]  Kefeng Zeng,et al.  A staphylococcal enterotoxin B magnetoelastic immunosensor. , 2004, Biosensors & bioelectronics.

[4]  C. Grimes,et al.  Viscosity measurements of viscous liquids using magnetoelastic thick-film sensors , 2000 .

[5]  Itamar Willner,et al.  Assembly of Microperoxidase-11 and Co(II)-Protoporphyrin IX Reconstituted Myoglobin Monolayers on Au-Electrodes: Integrated Bioelectrocatalytic Interfaces , 1997 .

[6]  D. D. Stubbs,et al.  Molecular recognition for electronic noses using surface acoustic wave immunoassay sensors , 2002 .

[7]  Craig A. Grimes,et al.  Remote query fluid-flow velocity measurement using magnetoelastic thick-film sensors (invited) , 2000 .

[8]  John Cookson,et al.  A survey of chemical and biological warfare , 1969 .

[9]  Shu-I Tu,et al.  1-Naphthyl phosphate as an enzymatic substrate for enzyme-linked immunomagnetic electrochemistry , 1999 .

[10]  M. Nieuwenhuizen,et al.  Detection of staphylococcal enterotoxin B employing a piezoelectric crystal immunosensor. , 1997, Biosensors & bioelectronics.

[11]  David R Franz,et al.  Medical Aspects of Chemical and Biological Warfare , 1997 .

[12]  Craig A. Grimes,et al.  Simultaneous measurement of liquid density and viscosity using remote query magnetoelastic sensors , 2000 .

[13]  Craig A. Grimes,et al.  The frequency response of magnetoelastic sensors to stress and atmospheric pressure , 2000 .

[14]  C A Grimes,et al.  Remote query measurement of pressure, fluid-flow velocity, and humidity using magnetoelastic thick-film sensors. , 2000, Sensors and actuators. A, Physical.

[15]  Kefeng Zeng,et al.  Magnetoelastic immunosensors: amplified mass immunosorbent assay for detection of Escherichia coli O157:H7. , 2003, Analytical chemistry.

[16]  Gérard Jaouen,et al.  Specific binding of avidin to biotin immobilised on modified gold surfaces: Fourier transform infrared reflection absorption spectroscopy analysis , 2002 .

[17]  J F Frank,et al.  Immunomagnetic separation and flow cytometry for rapid detection of Escherichia coli O157:H7. , 1998, Journal of food protection.

[18]  M S Bergdoll,et al.  Estimation of human dose of staphylococcal enterotoxin A from a large outbreak of staphylococcal food poisoning involving chocolate milk. , 1988, International journal of food microbiology.

[19]  Avraham Rasooly,et al.  Spectral surface plasmon resonance biosensor for detection of staphylococcal enterotoxin B in milk. , 2002, International journal of food microbiology.

[20]  S Yao,et al.  Rapid determination of ribonuclease and microanalysis of heparin with a SAW/conductance sensor. , 1997, Talanta.

[21]  Chuanmin Ruan,et al.  A bienzyme electrochemical biosensor coupled with immunomagnetic separation for rapid detection of Escherichia coli O157:H7 in food samples , 2002 .

[22]  Yanbin Li,et al.  Immunobiosensor chips for detection of Escherichia coil O157:H7 using electrochemical impedance spectroscopy. , 2002, Analytical chemistry.

[23]  C. Grimes,et al.  A remote query magnetoelastic pH sensor. , 2000, Sensors and actuators. B, Chemical.

[24]  W. Tsai,et al.  Piezoelectric crystal immunosensor for the detection of staphylococcal enterotoxin B. , 2003, Biosensors & bioelectronics.

[25]  Dimitris Kouzoudis,et al.  Monitoring blood coagulation with magnetoelastic sensors. , 2003, Biosensors & bioelectronics.

[26]  T. Miyamoto,et al.  Immunomagnetic flow cytometric detection of staphylococcal enterotoxin B in raw and dry milk. , 2003, Journal of food protection.

[27]  Edward T. Zellers,et al.  Vapor recognition with an integrated array of polymer-coated flexural plate wave sensors , 2000 .

[28]  Craig A. Grimes,et al.  Wireless Magnetoelastic Resonance Sensors: A Critical Review , 2002 .

[29]  Craig A. Grimes,et al.  Magneto-acoustic sensors for measurement of liquid temperature, viscosity and density , 2001 .

[30]  David S. Ballantine,et al.  Acoustic wave sensors : theory, design, and physico-chemical applications , 1997 .

[31]  Kefeng Zeng,et al.  A magnetoelastic bioaffinity-based sensor for avidin. , 2004, Biosensors & bioelectronics.

[32]  D. Franz,et al.  RICIN TOXIN , 2000 .

[33]  Craig A. Grimes,et al.  A Magnetoelastic Ricin Immunosensor , 2004 .

[34]  C A Grimes,et al.  A remote query magnetostrictive viscosity sensor. , 2000, Sensors and actuators. A, Physical.

[35]  Lisa C Shriver-Lake,et al.  Detection of staphylococcal enterotoxin B in spiked food samples. , 2003, Journal of food protection.

[36]  Craig A. Grimes,et al.  Magnetic field tuning of the frequency–temperature response of a magnetoelastic sensor , 2002 .

[37]  A. Gehring,et al.  Use of a light-addressable potentiometric sensor for the detection of Escherichia coli O157:H7. , 1998, Analytical biochemistry.

[38]  Craig A. Grimes,et al.  Magnetism-Based Remote Query Glucose Sensors , 2001 .

[39]  Craig A. Grimes,et al.  Control of a magnetoelastic sensor temperature response by magnetic field tuning , 2003 .

[40]  A P Turner,et al.  Immunomagnetic separation with mediated flow injection analysis amperometric detection of viable Escherichia coli O157. , 1998, Analytical chemistry.

[41]  Craig A. Grimes,et al.  Time domain characterization of oscillating sensors: Application of frequency counting to resonance frequency determination , 2002 .