I. Size and Shape of Cells, Occurrence of Mitoses

Summary. An extensive hypertrophy of the muscle coat develops in the small intestine of the guinea pig oral to an experimental stenosis. The profiles of smooth muscle cells become larger and irregular in shape. From the analysis of serial sections the arrangement of the muscle cells is less orderly than in control muscles. Many muscle cells are split into two or more branches over part of their length. The average cell volume is 3-4 times that of control muscle cells; the cell surface increases less dramatically and, in spite of the appearance of deep invaginations of the cell membrane, the surface-to-volume ratio falls from 1.4 to 0.8. The average cell length is only slightly increased compared with controls. Smooth muscle cells in mitosis are observed in all the hypertrophic muscles examined, in both muscle layers; in the circular musculature they occur mainly found in the middle part of the layer.

[1]  A. Bekoff,et al.  Physiological properties of dissociated muscle fibres obtained from innervated and denervated adult rat muscle. , 1977, The Journal of physiology.

[2]  F. Kummerow,et al.  Mitotic structures of aortic smooth muscle cells in swine and in culture: paired cisternae. , 1977, Journal of electron microscopy.

[3]  W. Gonyea,et al.  Skeletal muscle fiber splitting induced by weight-lifting exercise in cats. , 1977, Acta physiologica Scandinavica.

[4]  I. Östman-Smith Prevention of exercise-induced cardiac hypertrophy in rats by chemical sympathectomy (guanethidine treatment) , 1976, Neuroscience.

[5]  B. Johansson Structural and functional changes in rat portal veins after experimental portal hypertension. , 1976, Acta physiologica Scandinavica.

[6]  R. Bevan Effect of Sympathetic Denervation on Smooth Muscle Cell Proliferation in the Growing Rabbit Ear Artery , 1975, Circulation research.

[7]  F. D. Stephens,et al.  The response of smooth muscle cells in the rabbit urinary bladder to outflow obstruction. , 1975, Investigative urology.

[8]  J. McGeachie Smooth muscle regeneration. A review and experimental study. , 1974, Monographs in developmental biology.

[9]  J. James,et al.  Polyploidy in the human myometrium. , 1975, Zeitschrift fur mikroskopisch-anatomische Forschung.

[10]  G. Campbell,et al.  Mitosis of contractile smooth muscle cells in tissue culture. , 1974, Experimental cell research.

[11]  E. Atanassova,et al.  Smooth muscle cell regeneration in repair of gastric anastomosis in the dog , 1974, Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie.

[12]  R. Goss,et al.  Hypertrophy of the rat urinary bladder following reduction of its functional volume. , 1974, The Journal of experimental zoology.

[13]  G. Burnstock,et al.  An analysis of the interactions between sympathetic nerve fibers and smooth muscle cells in tissue culture. , 1973, Developmental biology.

[14]  G. Martin,et al.  Symposium on in vitro studies related to atherogenesis. Life histories of hyperplastoid cell lines from aorta and skin. , 1973, Experimental and molecular pathology.

[15]  R. Zak Cell proliferation during cardiac growth. , 1973, The American journal of cardiology.

[16]  L. Martin,et al.  Hypertrophy and hyperplasia in the mouse uterus after oestrogen treatment: an autoradiographic study. , 1973, The Journal of endocrinology.

[17]  P. Pfitzer Polyploide Zellkerne im Herzmuskel von Affen , 1972, Virchows Archiv B Cell Pathology.

[18]  R. Roth,et al.  Adrenergic Denervation of the Hypertrophied Gut Remnant , 1972, Annals of surgery.

[19]  M. Tilson Compensatory hypertrophy of the gut. Testing of the tissue mass, intraluminal nutrition and functional demand hypothesis. , 1972, Archives of surgery.

[20]  E. Weser,et al.  Studies of small bowel adaptation after intestinal resection in the rat. , 1971, Gastroenterology.

[21]  E. Hall-Craggs,et al.  The longitudinal division of fibres in overloaded rat skeletal muscle. , 1970, Journal of anatomy.

[22]  R. O'Neal,et al.  Ultrastructural features of aortic cells in mitosis in control and cholesterol-fed swine. , 1970, Laboratory investigation; a journal of technical methods and pathology.

[23]  P. Marchisio,et al.  Choline acetyltransferase activity of rabbit ileum wall. The effects of extrinsic and intrinsic denervation and of combined experimental hypertrophy. , 1970, Archives internationales de physiologie et de biochimie.

[24]  C. P. Leblond,et al.  NATURE OF DIVIDING NUCLEI IN SKELETAL MUSCLE OF GROWING RATS , 1970, The Journal of cell biology.

[25]  R. Miledi,et al.  Electron-microscopic structure of denervated skeletal muscle , 1969, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[26]  F. Manasek,et al.  MITOSIS IN DEVELOPING CARDIAC MUSCLE , 1968, The Journal of cell biology.

[27]  Rumyantsev Pp,et al.  The ultrastructure of differentiating cells of the heart muscle in the state of mitotic division. , 1968 .

[28]  R. Kempson,et al.  Stretch-induced myometrial hypertrophy. , 1967, Fertility and sterility.

[29]  W. Sandritter,et al.  Deoxyribonucleic Acid Content (Feulgen Photometry) and Dry Weight (Interference Microscopy) of Normal and Hypertrophic Heart Muscle Fibres , 1964, Nature.

[30]  B. Linge THE RESPONSE OF MUSCLE TO STRENUOUS EXERCISE , 1962 .

[31]  A. Csapo Smooth muscle as a contractile unit. , 1962, Physiological reviews. Supplement.

[32]  G. Nylander,et al.  Intestinal adaptation following extensive resection in the rat. , 1962, Acta chirurgica Scandinavica.

[33]  D. Grohmann [Mitotic growth potential of embryonic and fetal chicken hearts and its significance for the understanding of heart malformations]. , 1961, Zeitschrift fur Zellforschung und mikroskopische Anatomie.

[34]  C. Booth,et al.  Intestinal hypertrophy following partial resection of the small bowel in the rat , 1959, The British journal of surgery.

[35]  A. Benninghoff Vermehrung und Vergrößerung von Nervenzellen bei Hypertrophie des Innervationsgebietes , 1951 .

[36]  S. R. Reynolds,et al.  The rate of uterine growth resulting from chronic distention , 1937 .

[37]  E. Carey Studies in the dynamics of histogenesis. Tension of differential growth as a stimulus to myogenesis. VII. The experimental transformation of the smooth bladder muscle of the dog, histologically into cross‐striated muscle and physiologically into an organ manifesting rhythmicality , 1921 .

[38]  E. Carey STUDIES IN THE DYNAMICS OF HISTOGENESIS : I. TENSION OF DIFFERENTIAL GROWTH AS A STIMULUS TO MYOGENESIS. , 1920 .