Down-regulation of the antigen processing machinery is linked to a loss of inflammatory response in colorectal cancer.

[1]  B. Leggett,et al.  HLA‐DR expression is associated with better prognosis in sporadic Australian clinicopathological Stage C colorectal cancers , 2009, International journal of cancer.

[2]  Matt van de Rijn,et al.  Intraepithelial T cells and prognosis in ovarian carcinoma: novel associations with stage, tumor type, and BRCA1 loss , 2009, Modern Pathology.

[3]  S. Chae,et al.  Prognostic implications of type and density of tumour-infiltrating lymphocytes in gastric cancer , 2008, British Journal of Cancer.

[4]  A. Gemma,et al.  Predominant infiltration of macrophages and CD8+ T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer , 2008, Cancer.

[5]  Soldano Ferrone,et al.  HLA Class I Antigen Processing Machinery Component Expression and Intratumoral T-Cell Infiltrate as Independent Prognostic Markers in Ovarian Carcinoma , 2008, Clinical Cancer Research.

[6]  B. Seliger Molecular mechanisms of MHC class I abnormalities and APM components in human tumors , 2008, Cancer Immunology, Immunotherapy.

[7]  W. Weichert,et al.  Class I Histone Deacetylase Expression Has Independent Prognostic Impact in Human Colorectal Cancer: Specific Role of Class I Histone Deacetylases In vitro and In vivo , 2008, Clinical Cancer Research.

[8]  R. Gopaul,et al.  Combining the Antigen Processing Components TAP and Tapasin Elicits Enhanced Tumor-Free Survival , 2008, Clinical Cancer Research.

[9]  E. Jordanova,et al.  Association of antigen processing machinery and HLA class I defects with clinicopathological outcome in cervical carcinoma , 2007, Cancer Immunology, Immunotherapy.

[10]  E. Jordanova,et al.  Expression and genetic analysis of transporter associated with antigen processing in cervical carcinoma. , 2007, Gynecologic oncology.

[11]  V. Reuter,et al.  CD8 tumor-infiltrating lymphocytes are predictive of survival in muscle-invasive urothelial carcinoma , 2007, Proceedings of the National Academy of Sciences.

[12]  Maximilian Waldner,et al.  Colon cancer and the immune system: the role of tumor invading T cells. , 2006, World journal of gastroenterology.

[13]  Z. Trajanoski,et al.  Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome , 2006, Science.

[14]  S. Ferrone,et al.  HLA class I antigen down-regulation in primary laryngeal squamous cell carcinoma lesions as a poor prognostic marker. , 2006, Cancer research.

[15]  Gerd Ritter,et al.  Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[16]  S. Ferrone,et al.  Human Leukocyte Antigen and Antigen Processing Machinery Component Defects in Astrocytic Tumors , 2005, Clinical Cancer Research.

[17]  B. Seliger,et al.  Restoration of the expression of transporters associated with antigen processing in lung carcinoma increases tumor-specific immune responses and survival. , 2005, Cancer research.

[18]  B. Seliger,et al.  Defects in the Human Leukocyte Antigen Class I Antigen Processing Machinery in Head and Neck Squamous Cell Carcinoma: Association with Clinical Outcome , 2005, Clinical Cancer Research.

[19]  R. Tollenaar,et al.  Natural killer cells infiltrating colorectal cancer and MHC class I expression. , 2005, Molecular immunology.

[20]  George Coukos,et al.  Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival , 2004, Nature Medicine.

[21]  C. Ostwald,et al.  Prognostic role of CD8+ tumor-infiltrating lymphocytes in stage III colorectal cancer with and without microsatellite instability. , 2004, Human pathology.

[22]  H. Putter,et al.  Immune system and prognosis in colorectal cancer: a detailed immunohistochemical analysis , 2004, Laboratory Investigation.

[23]  S. Bustin,et al.  Tumour‐infiltrating lymphocytes in colorectal cancer with microsatellite instability are activated and cytotoxic , 2004, The British journal of surgery.

[24]  B. Seliger,et al.  MHC class I antigen processing pathway defects, ras mutations and disease stage in colorectal carcinoma , 2004, International journal of cancer.

[25]  T. Sasada,et al.  CD4+CD25+ regulatory T cells in patients with gastrointestinal malignancies , 2003, Cancer.

[26]  J. Hjelmborg,et al.  Prognostic value of the CD4+/CD8+ ratio of tumour infiltrating lymphocytes in colorectal cancer and HLA-DR expression on tumour cells , 2003, Cancer Immunology, Immunotherapy.

[27]  A. Rickinson,et al.  TAP-independent antigen presentation on MHC class I molecules: lessons from Epstein-Barr virus. , 2003, Microbes and infection.

[28]  Hein Putter,et al.  Down-Regulation of HLA-A Expression Correlates with a Better Prognosis in Colorectal Cancer Patients , 2002, Laboratory Investigation.

[29]  R. Lothe,et al.  Strong HLA-DR expression in microsatellite stable carcinomas of the large bowel is associated with good prognosis , 2002, British Journal of Cancer.

[30]  T. Eberlein,et al.  Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma1 , 2002, The Journal of Immunology.

[31]  P. Schlag,et al.  Prognostic significance of activated CD8(+) T cell infiltrations within esophageal carcinomas. , 2001, Cancer research.

[32]  B. Leggett,et al.  Tumour infiltrating lymphocytes and apoptosis are independent features in colorectal cancer stratified according to microsatellite instability status , 2001, Gut.

[33]  R. Dummer,et al.  TAP1 down‐regulation in primary melanoma lesions: An independent marker of poor prognosis , 2001, International journal of cancer.

[34]  M. Klemsz,et al.  Synergistic Induction of the Tap-1 Gene by IFN-γ and Lipopolysaccharide in Macrophages Is Regulated by STAT11 , 2000, The Journal of Immunology.

[35]  D. Hicklin,et al.  Down-regulation of HLA class I antigen-processing molecules in malignant melanoma: association with disease progression. , 1999, The American journal of pathology.

[36]  H Nagura,et al.  CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer. , 1998, Cancer research.

[37]  D. Hicklin,et al.  HLA class I antigen and transporter associated with antigen processing (TAP1 and TAP2) down-regulation in high-grade primary breast carcinoma lesions. , 1998, Cancer research.

[38]  R. Tampé,et al.  Reduced membrane major histocompatibility complex class I density and stability in a subset of human renal cell carcinomas with low TAP and LMP expression. , 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

[39]  W. Min,et al.  Kinetically coordinated induction of TAP1 and HLA class I by IFN-gamma: the rapid induction of TAP1 by IFN-gamma is mediated by Stat1 alpha. , 1996, Journal of immunology.

[40]  S. Tonegawa,et al.  TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4−8+ T cells , 1992, Cell.

[41]  P. Cresswell,et al.  Cytokines increase transporter in antigen processing-1 expression more rapidly than HLA class I expression in endothelial cells. , 1992, Journal of immunology.

[42]  R. Henderson,et al.  HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation. , 1992, Science.

[43]  P. Cresswell,et al.  Presentation of viral antigen by MHC class I molecules is dependent on a putative peptide transporter heterodimer , 1992, Nature.

[44]  R. Jaenisch,et al.  MHC class I deficiency: susceptibility to natural killer (NK) cells and impaired NK activity. , 1991, Science.

[45]  K. Koretz,et al.  Influence of major histocompatibility complex class I and II antigens on survival in colorectal carcinoma. , 1991, Cancer research.

[46]  P. Giacomini,et al.  Selective changes in expression of HLA class I polymorphic determinants in human solid tumors. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[47]  D. Ruiter,et al.  HLA antigens in colorectal tumours--low expression of HLA class I antigens in mucinous colorectal carcinomas. , 1987, British Journal of Cancer.

[48]  J. Jass Lymphocytic infiltration and survival in rectal cancer. , 1986, Journal of clinical pathology.

[49]  I. Ellis,et al.  Immunosurveillance is active in colorectal cancer as downregulation but not complete loss of MHC class I expression correlates with a poor prognosis , 2006, International journal of cancer.

[50]  Mads Hald Andersen,et al.  Cytotoxic T cells. , 2006, The Journal of investigative dermatology.

[51]  U. Ritz,et al.  Molecular mechanisms of HLA class I antigen abnormalities following viral infection and transformation , 2006, International journal of cancer.

[52]  A. Celada,et al.  Regulation of murine Tap1 and Lmp2 genes in macrophages by interferon gamma is mediated by STAT1 and IRF-1 , 2004, Genes and Immunity.