From Plant Compounds to Botanicals and Back: A Current Snapshot

This work aims at giving an updated picture of the strict interaction between main plant biologically active compounds and botanicals. The main features of the emerging class of dietary supplements, the botanicals, are highlighted. Focus is also on the definition of actual possibilities of study approach and research strategies. Examples of innovative directions are given: assessment of interaction of bioactive compounds, chemometrics and the new goal of biorefineries. Current models of existing databases, such as plant metabolic pathways, food composition, bioactive compounds, dietary supplements, and dietary markers, are described as usable tools for health research. The need for categorization of botanicals as well as for the implementation of specific and dedicated databases emerged, based on both analytical data and collected data taken from literature throughout a harmonized and standardized approach for the evaluation of an adequate dietary intake.

[1]  E. Feskens,et al.  Dietary and health biomarkers—time for an update , 2017, Genes & Nutrition.

[2]  Lucie A. Pfaltzgraff,et al.  Current and future trends in food waste valorization for the production of chemicals, materials and fuels: a global perspective , 2014 .

[3]  E. Ernst Herbal medicinal products. , 2002, The British journal of general practice : the journal of the Royal College of General Practitioners.

[4]  Minoru Kanehisa,et al.  KEGG Bioinformatics Resource for Plant Genomics and Metabolomics. , 2016, Methods in molecular biology.

[5]  J. Bircher,et al.  Understanding the nature of health: New perspectives for medicine and public health. Improved wellbeing at lower costs , 2016, F1000Research.

[6]  Craig Knox,et al.  PhytoHub V1.4: A new release for the online database dedicated to food phytochemicals and their human metabolites , 2016 .

[7]  D. Mcclements,et al.  Food-Grade Covalent Complexes and Their Application as Nutraceutical Delivery Systems: A Review. , 2017, Comprehensive reviews in food science and food safety.

[8]  Li-fang Zhang,et al.  An Approach for Searching Bioactive Compounds from Traditional Chinese Plant Food and Herb Medicines by Investigating Spectrum–Effect Relationships , 2017 .

[9]  S. Tripathi,et al.  Concept of standardization, extraction and pre phytochemical screening strategies for herbal drug , 2014 .

[10]  Jidong Sun Safety and Clinical Applications , 2007 .

[11]  U. Rashid,et al.  An overview of recent developments in metabolomics and proteomics – phytotherapic research perspectives , 2017 .

[12]  S. Sturm,et al.  Recent advances on HPLC/MS in medicinal plant analysis—An update covering 2011–2016 , 2018, Journal of pharmaceutical and biomedical analysis.

[13]  David S. Wishart,et al.  Phenol-Explorer 3.0: a major update of the Phenol-Explorer database to incorporate data on the effects of food processing on polyphenol content , 2013, Database J. Biol. Databases Curation.

[14]  Annarita Paiano,et al.  Circular Economy as a New Model for the Exploitation of the Agroindustrial Biomass , 2016 .

[15]  Vinod Kumar,et al.  Food waste: a potential bioresource for extraction of nutraceuticals and bioactive compounds , 2017, Bioresources and Bioprocessing.

[16]  David B. Haytowitz,et al.  USDA Database for the Flavonoid Content of Selected Foods Release 3.2 , 2015 .

[17]  Rachel Berry,et al.  Assessing and improving the quality of food composition databases for nutrition and health applications in Europe: the contribution of EuroFIR. , 2014, Advances in nutrition.

[18]  F. Verpoort,et al.  Plant Food Residues as a Source of Nutraceuticals and Functional Foods , 2016, Foods.

[19]  David S. Wishart,et al.  HMDB 4.0: the human metabolome database for 2018 , 2017, Nucleic Acids Res..

[20]  W. Rand,et al.  Report of a planning conference concerning an international network of food data systems (INFOODS). , 1984, The American journal of clinical nutrition.

[21]  Lucie A. Pfaltzgraff,et al.  Food waste biomass: a resource for high-value chemicals , 2013 .

[22]  P. Restani,et al.  ePlantLIBRA: A composition and biological activity database for bioactive compounds in plant food supplements. , 2016, Food chemistry.

[23]  R. V. van Breemen Development of Safe and Effective Botanical Dietary Supplements , 2015, Journal of medicinal chemistry.

[24]  E. Gibney,et al.  Addressing the inter‐individual variation in response to consumption of plant food bioactives: Towards a better understanding of their role in healthy aging and cardiometabolic risk reduction , 2016, Molecular nutrition & food research.

[25]  P Finglas,et al.  EuroFIR eBASIS: application for health claims submissions and evaluations , 2010, European Journal of Clinical Nutrition.

[26]  D. Schrenk,et al.  Bioactive compounds: definition and assessment of activity. , 2009, Nutrition.

[27]  A. Brown An overview of herb and dietary supplement efficacy, safety and government regulations in the United States with suggested improvements. Part 1 of 5 series. , 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[28]  Yizeng Liang,et al.  Recent advances in the compound-oriented and pattern-oriented approaches to the quality control of herbal medicines , 2008, Chinese medicine.

[29]  Jidong Sun D-Limonene: safety and clinical applications. , 2007, Alternative medicine review : a journal of clinical therapeutic.

[30]  D. Shaw,et al.  Pharmacovigilance of herbal medicine. , 2012, Journal of ethnopharmacology.

[31]  A. Sureda,et al.  Hypotensive effects of genistein: From chemistry to medicine. , 2017, Chemico-biological interactions.

[32]  Yeng Chen,et al.  Extraction, isolation and characterization of bioactive compounds from plants' extracts. , 2010, African journal of traditional, complementary, and alternative medicines : AJTCAM.

[33]  A. Baiano Recovery of Biomolecules from Food Wastes — A Review , 2014, Molecules.

[34]  J. Milner,et al.  A free new dietary supplement label database for registered dietitian nutritionists. , 2014, Journal of the Academy of Nutrition and Dietetics.

[35]  David S. Wishart,et al.  Phenol-Explorer: an online comprehensive database on polyphenol contents in foods , 2010, Database J. Biol. Databases Curation.

[36]  Ying Zhang,et al.  HMDB: the Human Metabolome Database , 2007, Nucleic Acids Res..

[37]  Mohd Shahir Shamsir Omar,et al.  Review: DNA Barcoding and Chromatography Fingerprints for the Authentication of Botanicals in Herbal Medicinal Products , 2017, Evidence-based complementary and alternative medicine : eCAM.

[38]  Vito Verardo,et al.  Food Use for Social Innovation by Optimizing Food Waste Recovery Strategies , 2016 .

[39]  A. Durazzo CHAPTER 3:Extractable and Non-extractable Polyphenols: an Overview , 2018 .

[40]  Paul Finglas,et al.  eBASIS (Bioactive Substances in Food Information Systems) and Bioactive Intakes: Major Updates of the Bioactive Compound Composition and Beneficial Bioeffects Database and the Development of a Probabilistic Model to Assess Intakes in Europe , 2017, Nutrients.

[41]  P. Clifton,et al.  Polyphenols and Glycemic Control , 2016, Nutrients.

[42]  M. Banach,et al.  Editorial: Natural Products as the Integral Part of the Therapy? , 2017, Current pharmaceutical design.

[43]  A. Bansal,et al.  Chemometrics: A new scenario in herbal drug standardization , 2014, Journal of pharmaceutical analysis.

[44]  A. Durazzo Study Approach of Antioxidant Properties in Foods: Update and Considerations , 2017, Foods.

[45]  David S. Wishart,et al.  Phenol-Explorer 2.0: a major update of the Phenol-Explorer database integrating data on polyphenol metabolism and pharmacokinetics in humans and experimental animals , 2012, Database J. Biol. Databases Curation.

[46]  Charis M. Galanakis Recovery of high added-value components from food wastes: Conventional, emerging technologies and commercialized applications , 2012 .

[47]  S. Gupta,et al.  PRELIMINARY PHYTOCHEMICAL SCREENING OF SIX MEDICINAL PLANTS USED IN TRADITIONAL MEDICINE , 2014 .

[48]  Kazuki Saito,et al.  Metabolomics for functional genomics, systems biology, and biotechnology. , 2010, Annual review of plant biology.

[49]  P. Shankar,et al.  Essential medicines and health products information portal , 2014, Journal of pharmacology & pharmacotherapeutics.

[50]  Ni Ai,et al.  A Bioactive Chemical Markers Based Strategy for Quality Assessment of Botanical Drugs: Xuesaitong Injection as a Case Study , 2017, Scientific Reports.

[51]  G. Du,et al.  Polyphenols: Potential source of drugs for the treatment of ischaemic heart disease. , 2016, Pharmacology & therapeutics.

[52]  J E Harrison,et al.  Nutritional assessment. , 1994, Blood purification.

[53]  Liliana Jiménez,et al.  Dietary Polyphenols and the Prevention of Diseases , 2005, Critical reviews in food science and nutrition.

[54]  Pei Chen,et al.  Botanical supplements: Detecting the transition from ingredient to product , 2017 .

[55]  M. Ekor,et al.  The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety , 2014, Front. Pharmacol..

[56]  A. Romani,et al.  Sustainability, Innovation, and Green Chemistry in the Production and Valorization of Phenolic Extracts from Olea europaea L. , 2016 .

[57]  Robert Petryszak,et al.  Plant Reactome: a resource for plant pathways and comparative analysis , 2016, Nucleic Acids Res..

[58]  M. Monagas,et al.  Quality specifications for articles of botanical origin from the United States Pharmacopeia. , 2018, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[59]  Raymond D. Boisvert,et al.  A Critical Conversation on Paul B. Thompson's From Field to Fork: Food Ethics for Everyone , 2015, Public Philosophy Journal.

[60]  Rong-hong Zhang,et al.  Prodrugs of triterpenoids and their derivatives. , 2017, European journal of medicinal chemistry.

[61]  Liping Qu,et al.  European regulation model for herbal medicine: The assessment of the EU monograph and the safety and efficacy evaluation in marketing authorization or registration in Member States. , 2018, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[62]  W. Stahel The circular economy , 2016, Nature.

[63]  Songhua Hu,et al.  Adjuvant activities of saponins from traditional Chinese medicinal herbs. , 2009, Vaccine.

[65]  V. Kuete Health Effects of Alkaloids from African Medicinal Plants , 2014 .

[66]  Health is state of physical, mental, and social wellbeing , 2011, BMJ : British Medical Journal.

[67]  Foo-Tim Chau,et al.  Chemical information of Chinese medicines: A challenge to chemist , 2006 .

[68]  M. Wong,et al.  The Use of Omic Technologies Applied to Traditional Chinese Medicine Research , 2017, Evidence-based complementary and alternative medicine : eCAM.

[69]  K. Ingle,et al.  Phytochemicals: Extraction methods, identification and detection of bioactive compounds from plant extracts , 2017 .