LacI transgenic animal study: relationships among DNA-adduct levels, mutant frequencies and cancer incidences.
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T. Sugimura | T. Ushijima | M. Nagao | T Sugimura | M Nagao | T Ushijima | M Ochiai | E Okochi | M. Ochiai | E. Okochi
[1] T. Sugimura,et al. DNA adduct level induced by 2-amino-3,4-dimethylimidazo[4,5-f]-quinoline in Big Blue mice does not correlate with mutagenicity. , 1998, Mutagenesis.
[2] J. Tucker,et al. Intestinal mutagenicity of two carcinogenic food mutagens in transgenic mice: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and amino(alpha)carboline. , 1996, Carcinogenesis.
[3] J. Weaver,et al. 32P-postlabeling analysis of DNA adducts persisting for up to 42 weeks in the skin, epidermis and dermis of mice treated topically with 7,12-dimethylbenz[a]anthracene. , 1985, Carcinogenesis.
[4] D W Gaylor,et al. Tumors and DNA adducts in mice exposed to benzo[a]pyrene and coal tars: implications for risk assessment. , 1998, Environmental health perspectives.
[5] S. Thorgeirsson,et al. Lack of Carcinogenicity of 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline (MeIQx) in Cynomolgus Monkeys , 1999, Japanese journal of cancer research : Gann.
[6] T. Sugimura,et al. DNA Modification by 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine in Rats , 1989, Japanese journal of cancer research : Gann.
[7] N Ito,et al. The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods. , 1997, Cancer research.
[8] T. Sugimura,et al. How we should deal with unavoidable exposure of man to environmental mutagens: cooked food mutagen discovery, facts and lessons for cancer prevention. , 2000, Mutation research.
[9] M. Nagao,et al. A new approach to risk estimation of food-borne carcinogens--heterocyclic amines--based on molecular information. , 1999, Mutation research.
[10] T. Sugimura,et al. No direct correlation between mutant frequencies and cancer incidence induced by MeIQ in various organs of Big Blue mice. , 1998, Mutation research.
[11] D. Phillips,et al. Tissue distribution of DNA adducts in CDF1 mice fed 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ). , 1990, Carcinogenesis.
[12] C. Potten,et al. Stem cells: the intestinal stem cell as a paradigm. , 2000, Carcinogenesis.
[13] H. Kataoka,et al. Determination of Mutagenic Heterocyclic Amines in Combustion Smoke Samples , 1998, Bulletin of environmental contamination and toxicology.
[14] H. Bartsch,et al. Analysis of DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine in rat and human tissues by alkaline hydrolysis and gas chromatography/electron capture mass spectrometry: validation by comparison with 32P-postlabeling. , 1994, Chemical research in toxicology.
[15] L. Boldrini,et al. Targeting of O6-methylguanine-DNA methyltransferase (MGMT) activity by antimessenger oligonucleotide sensitizes CHO/Mex+ transfected cells to mitozolomide. , 1996, Carcinogenesis.
[16] T. Mikami,et al. Comparison between in vivo mutagenicity and carcinogenicity in multiple organs by benzo[a]pyrene in the lacZ transgenic mouse (Muta Mouse). , 1998, Mutation research.
[17] J. Short,et al. Transgenic systems for in vivo mutation analysis. , 1993, Mutation research.
[18] G. R. Stuart,et al. Effects of gender and species on spectra of mutation induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the lacI transgene. , 1997, Mutation research.
[19] M A Butler,et al. Rapid metabolic phenotypes for acetyltransferase and cytochrome P4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps. , 1994, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
[20] N Ito,et al. A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). , 1991, Carcinogenesis.
[21] K T Bogen,et al. Cancer risk of heterocyclic amines in cooked foods: an analysis and implications for research. , 1995, Carcinogenesis.
[22] H. Bartsch,et al. Metabolic activation and DNA adduct detection of PhIP in dogs, rats, and humans in relation to urinary bladder and colon carcinogenesis. , 1995, Princess Takamatsu symposia.
[23] T. Sugimura,et al. Detection of Guanine‐C8‐2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine Adduct as a Single Spot on Thin‐layer Chromatography by Modification of the 32P‐Postlabeling Method , 1994, Japanese journal of cancer research : Gann.
[24] T. Sugimura,et al. A new modification of the 32P-post-labeling method to recover IQ-DNA adducts as mononucleotides. , 1999, Mutagenesis.
[25] T. Sugimura,et al. DNA adduct formation, cell proliferation and aberrant crypt focus formation induced by PhIP in male and female rat colon with relevance to carcinogenesis. , 1996, Carcinogenesis.
[26] M. Toyota,et al. Specific 5'-GGGA-3'-->5'-GGA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[27] T. Sugimura,et al. Identification of N-(deoxyguanosin-8-yl)-2-amino-3,4-dimethylimidazo[4,5-f]quinoline (dG-C8-MeIQ) as a major adduct formed by MeIQ with nucleotides in vitro with DNA in vivo. , 1994, Carcinogenesis.