Development and testing of an accessible and reproducible experimental model of sleeve gastrectomy in rats

: Based on the results of bariatric surgery on metabolic syndrome (MS) that are not exclusively associated with weight loss, it is pertinent to analyze the modifications of MS blood variables, inflammatory biomarkers, and oxidative stress in an experimental model. The experimental models for this purpose described so far are complex, expensive, and difficult to reproduce. An experimental analytical study was carried out using male Wistar rats. The animals were divided into 6 groups of 12 rats each: control (C), metabolic injury (MS), sleeve gastrectomy (SG), MS + SG for 6 (SG6), 12 (SG12), and 24 ( SG24) weeks. Oxidative and metabolic variables, weight loss, and food intake were evaluated. MS was induced by administration of 10% fructose diluted in drinking water for 6 weeks. oxidative and metabolic variables showed significant differences when comparing the MS group with the rest of the groups with a progressive improvement in the groups operated on for SG. The model proved to be safe and reproducible. The metabolic injury generated and the results obtained from SG tended to emulate those observed in humans.