Dual-responsive nanocarriers from star shaped poly(N-isopropylacrylamide) coated mesoporous silica for drug delivery

Abstract The pH and temperature dual-responsive nanocarriers were fabricated from 2-mercaptobenzimidazole modified mesoporous silica nanoparticles (MSN-BM) and poly(N-isopropylacrylamide) star polymer based on β-cyclodextrin core（β-CD-(PNIPAM)7）coated as nanovalve by host-guest recognition. Nanoparticles show a well-ordered mesoporous structure with the pore diameter of 2–3 nm and size was about 100–150 nm. Doxorubicin (DOX) was effectively encapsulated in MSNs with the drug-loading content and entrapment efficiency up to 40.51 and 85.11%, respectively. The opening of the pores could be switched on and off by the stimulating factors, such as acid and temperature as desired. The higher the concentration of acid, the more of DOX was released from nanoparticles. Furthermore, the release of DOX from composite nanoparticles was enhanced with the temperature increased from 25 to 42 °C. Graphical Abstract

[1]  F. Guo,et al.  Synthesis of temperature/pH dual-sensitive supramolecular micelles from β-cyclodextrin-poly(N-isopropylacrylamide) star polymer for drug delivery. , 2018, Colloids and surfaces. B, Biointerfaces.

[2]  Ping Wang,et al.  pH-responsive nanoreservoirs based on hyaluronic acid end-capped mesoporous silica nanoparticles for targeted drug delivery. , 2018, International journal of biological macromolecules.

[3]  S. Rajput,et al.  Etoposide encapsulated functionalized mesoporous silica nanoparticles: Synthesis, characterization and effect of functionalization on dissolution kinetics in simulated and biorelevant media , 2018 .

[4]  M. Vallet‐Regí,et al.  Mesoporous silica nanoparticles functionalized with hyaluronic acid. Effect of the biopolymer chain length on cell internalization. , 2018, Colloids and surfaces. B, Biointerfaces.

[5]  Hamida Panezai,et al.  Dual (pH- and temperature-) stimuli responsive nanocarrier with bimodal mesoporous silica nanoparticles core and copolymer shell for controlled ibuprofen-releasing: Fractal feature and diffusion mechanism , 2017 .

[6]  Guiying Li,et al.  Supramolecular assembly of poly(β-cyclodextrin) block copolymer and benzimidazole-poly(ε-caprolactone) based on host-guest recognition for drug delivery. , 2017, Colloids and surfaces. B, Biointerfaces.

[7]  Jian-tao Lin,et al.  pH and redox dual stimulate-responsive nanocarriers based on hyaluronic acid coated mesoporous silica for targeted drug delivery. , 2017, Materials science & engineering. C, Materials for biological applications.

[8]  D. Ma,et al.  Redox-responsive nanocarriers for drug and gene co-delivery based on chitosan derivatives modified mesoporous silica nanoparticles. , 2017, Colloids and surfaces. B, Biointerfaces.

[9]  D. Gomes,et al.  Multifunctional mesoporous silica nanoparticles for cancer-targeted, controlled drug delivery and imaging , 2017 .

[10]  Jun Hu,et al.  Transferrin gated mesoporous silica nanoparticles for redox-responsive and targeted drug delivery. , 2017, Colloids and surfaces. B, Biointerfaces.

[11]  L. Belyakova,et al.  Mesoporous silica nanoparticles equipped with surface nanovalves for pH-controlled liberation of doxorubicin , 2016, Interface Focus.

[12]  X. Zhu,et al.  pH and redox-operated nanovalve for size-selective cargo delivery on hollow mesoporous silica spheres. , 2016, Journal of colloid and interface science.

[13]  R. Zhuo,et al.  Dual‐stimuli‐responsive polymer‐coated mesoporous silica nanoparticles used for controlled drug delivery , 2015 .

[14]  R. Martínez‐Máñez,et al.  Gated mesoporous silica nanoparticles for the controlled delivery of drugs in cancer cells. , 2015, Langmuir : the ACS journal of surfaces and colloids.

[15]  Guiying Li,et al.  Hybrid vesicles co-assembled from anionic graft copolymer and metal ions for controlled drug release , 2015 .

[16]  Xuezhong Du,et al.  Pillar[6]arene-valved mesoporous silica nanovehicles for multiresponsive controlled release. , 2014, ACS applied materials & interfaces.

[17]  Yanli Zhao,et al.  Synthesis and in vitro evaluation of charge reversal photoresponsive quinoline tethered mesoporous silica for targeted drug delivery. , 2014, Journal of materials chemistry. B.

[18]  Guiying Li,et al.  Synthesis of thermo-sensitive polyelectrolyte complex nanoparticles from CS-g-PNIPAM and SA-g-PNIPAM for controlled drug release , 2014, Macromolecular Research.

[19]  Junsheng Liu,et al.  Formation of thermo-sensitive polyelectrolyte complex micelles from two biocompatible graft copolymers for drug delivery. , 2014, Journal of biomedical materials research. Part A.

[20]  Cristina Martín,et al.  Ultrafast dynamics of C30 in solution and within CDs and HSA protein. , 2014, The journal of physical chemistry. B.

[21]  Chuanglong He,et al.  Effect of pH-responsive alginate/chitosan multilayers coating on delivery efficiency, cellular uptake and biodistribution of mesoporous silica nanoparticles based nanocarriers. , 2014, ACS applied materials & interfaces.

[22]  Xuesi Chen,et al.  Cisplatin crosslinked pH-sensitive nanoparticles for efficient delivery of doxorubicin. , 2014, Biomaterials.

[23]  R. Martínez‐Máñez,et al.  Glucose-triggered release using enzyme-gated mesoporous silica nanoparticles. , 2013, Chemical communications.

[24]  R. Zhuo,et al.  Multifunctional envelope-type mesoporous silica nanoparticles for tumor-triggered targeting drug delivery. , 2013, Journal of the American Chemical Society.

[25]  Guiying Li,et al.  Self-assembled nanoparticles from thermo-sensitive polyion complex micelles for controlled drug release , 2011 .

[26]  J. Zink,et al.  pH-Operated mechanized porous silicon nanoparticles. , 2011, Journal of the American Chemical Society.

[27]  W. Nau,et al.  Supramolecular encapsulation of benzimidazole-derived drugs by cucurbit[7]uril , 2011 .

[28]  J. F. Stoddart,et al.  Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves. , 2010, Journal of the American Chemical Society.

[29]  Guiying Li,et al.  Complex micelles formed from two diblock copolymers for applications in controlled drug release , 2009 .

[30]  L. F. Zara,et al.  Modification of silica gel by attachment of 2-mercaptobenzimidazole for use in removing Hg(II) from aqueous media: a thermodynamic approach. , 2007, Journal of colloid and interface science.

[31]  M. Jaroniec,et al.  Tailoring Surface and Structural Properties of MCM-41 Silicas by Bonding Organosilanes , 1998 .