Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer’s Disease

[1]  K. Marder,et al.  RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk , 2013, Neuron.

[2]  A. Singleton,et al.  TREM2 variants in Alzheimer's disease. , 2013, The New England journal of medicine.

[3]  A. Hofman,et al.  Variant of TREM2 associated with the risk of Alzheimer's disease. , 2013, The New England journal of medicine.

[4]  M. Heneka,et al.  NLRP3 is activated in Alzheimer´s disease and contributes to pathology in APP/PS1 mice , 2012, Nature.

[5]  Guoxing Wang,et al.  Receptor Signaling Lymphocyte-activation Molecule Family 1 (Slamf1) Regulates Membrane Fusion and NADPH Oxidase 2 (NOX2) Activity by Recruiting a Beclin-1/Vps34/Ultraviolet Radiation Resistance-associated Gene (UVRAG) Complex* , 2012, The Journal of Biological Chemistry.

[6]  L. Mei,et al.  VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology , 2011, The Journal of cell biology.

[7]  Cole M. Haynes,et al.  Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes , 2011, Nature Cell Biology.

[8]  D. Green,et al.  Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells , 2011, Proceedings of the National Academy of Sciences.

[9]  M. Giustetto,et al.  Synaptic Pruning by Microglia Is Necessary for Normal Brain Development , 2011, Science.

[10]  M. Farrer,et al.  VPS35 mutations in Parkinson disease. , 2011, American journal of human genetics.

[11]  Marc N. Offman,et al.  A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease. , 2011, American journal of human genetics.

[12]  D. Hall,et al.  The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy in C. elegans , 2011, Autophagy.

[13]  H. Virgin,et al.  Autophagy in immunity and inflammation , 2011, Nature.

[14]  H. Okada,et al.  BACE1 Retrograde Trafficking Is Uniquely Regulated by the Cytoplasmic Domain of Sortilin* , 2011, The Journal of Biological Chemistry.

[15]  J. Grutzendler,et al.  CX3CR1 in Microglia Regulates Brain Amyloid Deposition through Selective Protofibrillar Amyloid-β Phagocytosis , 2010, The Journal of Neuroscience.

[16]  M. Boes,et al.  SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages , 2010, Nature Immunology.

[17]  D. Westaway,et al.  Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations , 2010, Cell.

[18]  E. Masliah,et al.  Regulation of Amyloid Precursor Protein Processing by the Beclin 1 Complex , 2010, PloS one.

[19]  S. Gygi,et al.  Network organization of the human autophagy system , 2010, Nature.

[20]  Qing Jun Wang,et al.  The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond. , 2010, Trends in cell biology.

[21]  K. Shokat,et al.  Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34 , 2010, Science.

[22]  Chonglin Yang,et al.  Retromer Is Required for Apoptotic Cell Clearance by Phagocytic Receptor Recycling , 2010, Science.

[23]  D. Galasko,et al.  Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy , 2010, PloS one.

[24]  Rosemary O’Connor,et al.  Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling , 2010, Neurobiology of Aging.

[25]  S. Smale.  Transfection by electroporation of RAW 264.7 macrophages. , 2010, Cold Spring Harbor protocols.

[26]  F. Heppner,et al.  Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia , 2009, Nature Neuroscience.

[27]  E. Masliah,et al.  Beclin 1 Gene Transfer Activates Autophagy and Ameliorates the Neurodegenerative Pathology in α-Synuclein Models of Parkinson's and Lewy Body Diseases , 2009, The Journal of Neuroscience.

[28]  Tony Wyss-Coray,et al.  Immune Activation in Brain Aging and Neurodegeneration: Too Much or Too Little? , 2009, Neuron.

[29]  Brian Spencer,et al.  The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. , 2008, The Journal of clinical investigation.

[30]  Jun Tan,et al.  Blocking TGF-β–Smad2/3 innate immune signaling mitigates Alzheimer-like pathology , 2008, Nature Medicine.

[31]  D. Holtzman,et al.  Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease , 2008, Nature.

[32]  B. Oh,et al.  Structural and Biochemical Bases for the Inhibition of Autophagy and Apoptosis by Viral BCL-2 of Murine γ-Herpesvirus 68 , 2008, PLoS pathogens.

[33]  D. Green,et al.  Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis , 2007, Nature.

[34]  Wei Zhang,et al.  HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. , 2007, Cell host & microbe.

[35]  Qihua Sun,et al.  Autophagy Gene-Dependent Clearance of Apoptotic Cells during Embryonic Development , 2007, Cell.

[36]  T. Nishioku,et al.  Cathepsin E Deficiency Induces a Novel Form of Lysosomal Storage Disorder Showing the Accumulation of Lysosomal Membrane Sialoglycoproteins and the Elevation of Lysosomal pH in Macrophages* , 2007, Journal of Biological Chemistry.

[37]  J. Meldolesi,et al.  Triggering receptor expressed in myeloid cells 2 (TREM2) trafficking in microglial cells: Continuous shuttling to and from the plasma membrane regulated by cell stimulation , 2006, Neuroscience.

[38]  L. Mucke,et al.  Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology. , 2006, The Journal of clinical investigation.

[39]  L. Honig,et al.  Model‐guided microarray implicates the retromer complex in Alzheimer's disease , 2005, Annals of neurology.

[40]  B. Hyman,et al.  Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[41]  F. Helmchen,et al.  Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo , 2005, Science.

[42]  Masaaki Komatsu,et al.  Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice , 2005, The Journal of cell biology.

[43]  Takeshi Tokuhisa,et al.  The role of autophagy during the early neonatal starvation period , 2004, Nature.

[44]  D. Morgan,et al.  Time-dependent reduction in Aβ levels after intracranial LPS administration in APP transgenic mice , 2004, Experimental Neurology.

[45]  R. Pagano,et al.  Ligand-dependent and -independent transforming growth factor-beta receptor recycling regulated by clathrin-mediated endocytosis and Rab11. , 2004, Molecular biology of the cell.

[46]  Govind Bhagat,et al.  Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. , 2003, The Journal of clinical investigation.

[47]  Arnold J. Levine,et al.  Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[48]  K. Moore,et al.  CD36 Mediates the Innate Host Response to β-Amyloid , 2003, The Journal of experimental medicine.

[49]  F. Gage,et al.  Neprilysin Gene Transfer Reduces Human Amyloid Pathology in Transgenic Mice , 2003, The Journal of Neuroscience.

[50]  K. Tan-Takeuchi,et al.  Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice. , 2003, The Journal of clinical investigation.

[51]  S. Emr,et al.  Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase , 2002, Journal of Cell Science.

[52]  N. Heintz,et al.  A Novel Protein Complex Linking the δ2 Glutamate Receptor and Autophagy Implications for Neurodegeneration in Lurcher Mice , 2002, Neuron.

[53]  John D Lambris,et al.  Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[54]  L. Lue,et al.  Modeling microglial activation in Alzheimer’s disease with human postmortem microglial cultures , 2001, Neurobiology of Aging.

[55]  S. Grinstein,et al.  Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation , 2001, The Journal of cell biology.

[56]  Qingxian Lu,et al.  Homeostatic Regulation of the Immune System by Receptor Tyrosine Kinases of the Tyro 3 Family , 2001, Science.

[57]  L. Mucke,et al.  TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice , 2001, Nature Medicine.

[58]  R. Motter,et al.  Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease , 2000, Nature Medicine.

[59]  R. Wenthold,et al.  Distribution of Glutamate Receptor Subunit NMDAR1 in the Hippocampus of Normal Elderly and Patients with Alzheimer's Disease , 1999, Experimental Neurology.

[60]  S. Goff,et al.  Tyro-3 family receptors are essential regulators of mammalian spermatogenesis , 1999, Nature.

[61]  A. Singleton,et al.  TREM2 Variants in Alz hei mer's Disease , 2012 .

[62]  F. Heppner,et al.  Formation and maintenance of Alzheimer’s disease beta-amyloid plaques in the absence of microglia , 2010 .