Gene expression changes caused by the p38 MAPK inhibitor dilmapimod in COPD patients: analysis of blood and sputum samples from a randomized, placebo-controlled clinical trial
暂无分享,去创建一个
C. Larminie | Dave Singh | R. Tal-Singer | R. Mayer | S. Bates | J. Betts | C. Clayton | L. Warnock | B. E. Hoffman
[1] G. Shurin,et al. C-reactive protein and lung diseases. , 2014, The international journal of biochemistry & cell biology.
[2] H. Watz,et al. Efficacy and safety of the p38 MAPK inhibitor losmapimod for patients with chronic obstructive pulmonary disease: a randomised, double-blind, placebo-controlled trial. , 2014, The Lancet. Respiratory medicine.
[3] L. Edwards,et al. Lessons from ECLIPSE: a review of COPD biomarkers , 2013, Thorax.
[4] Dave Singh. P38 inhibition in COPD; cautious optimism , 2013, Thorax.
[5] W. MacNee,et al. Efficacy and safety of the oral p38 inhibitor PH-797804 in chronic obstructive pulmonary disease: a randomised clinical trial , 2013, Thorax.
[6] Dave Singh,et al. Increased phosphorylated p38 mitogen-activated protein kinase in COPD lungs , 2012, European Respiratory Journal.
[7] M. Neerman-Arbez,et al. Fibrinogen gene regulation , 2012, Thrombosis and Haemostasis.
[8] D. Lomas,et al. An Oral Inhibitor of p38 MAP Kinase Reduces Plasma Fibrinogen in Patients With Chronic Obstructive Pulmonary Disease , 2012, Journal of clinical pharmacology.
[9] Carla M. T. Bauer,et al. IL-1α/IL-1R1 Expression in Chronic Obstructive Pulmonary Disease and Mechanistic Relevance to Smoke-Induced Neutrophilia in Mice , 2011, PloS one.
[10] Christopher E Brightling,et al. Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers. , 2011, American journal of respiratory and critical care medicine.
[11] C. Harbron,et al. Synergistic Effects of p38 Mitogen-Activated Protein Kinase Inhibition with a Corticosteroid in Alveolar Macrophages from Patients with Chronic Obstructive Pulmonary Disease , 2011, Journal of Pharmacology and Experimental Therapeutics.
[12] K. Chung,et al. p38 mitogen-activated protein kinase pathways in asthma and COPD. , 2011, Chest.
[13] B. Lambrecht,et al. Role of IL-1&agr; and the Nlrp3/caspase-1/IL-1&bgr; axis in cigarette smoke-induced pulmonary inflammation and COPD , 2011, European Respiratory Journal.
[14] Stanley B. Cohen,et al. A 24-Week, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study of the Efficacy of Oral SCIO-469, a p38 Mitogen-activated Protein Kinase Inhibitor, in Patients with Active Rheumatoid Arthritis , 2011, The Journal of Rheumatology.
[15] A. Cuadrado,et al. Mechanisms and functions of p38 MAPK signalling. , 2010, The Biochemical journal.
[16] A. Whitmarsh. A central role for p38 MAPK in the early transcriptional response to stress , 2010, BMC Biology.
[17] Axel Weber,et al. Interleukin-1 (IL-1) Pathway , 2010, Science Signaling.
[18] Dave Singh,et al. A Randomized, Placebo‐Controlled Study of the Effects of the p38 MAPK Inhibitor SB‐681323 on Blood Biomarkers of Inflammation in COPD Patients , 2010, Journal of clinical pharmacology.
[19] T. Cheng,et al. Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis. , 2009, Arthritis and rheumatism.
[20] M. Genovese. Inhibition of p38: has the fat lady sung? , 2009, Arthritis and rheumatism.
[21] L. Fabbri,et al. Increased activation of p38 MAPK in COPD , 2008, European Respiratory Journal.
[22] A. Nicholson,et al. Different Mitogen-Activated Protein Kinase-Dependent Cytokine Responses in Cells of the Monocyte Lineage , 2008, Journal of Pharmacology and Experimental Therapeutics.
[23] J. Friedland,et al. Matrix metalloproteinases in destructive pulmonary pathology , 2005, Thorax.
[24] C. Jobin,et al. NF-κB inducing kinase activates NF-κB transcriptional activity independently of IκB kinase γ through a p38 MAPK-dependent RelA phosphorylation pathway , 2004 .
[25] A. Baldwin,et al. Oncoprotein Suppression of Tumor Necrosis Factor-induced NFκB Activation Is Independent of Raf-controlled Pathways* , 2003, Journal of Biological Chemistry.
[26] J. Boehm,et al. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases , 2003, Nature Reviews Drug Discovery.
[27] Terence P. Speed,et al. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias , 2003, Bioinform..
[28] Marty W. Mayo,et al. Akt Stimulates the Transactivation Potential of the RelA/p65 Subunit of NF-κB through Utilization of the IκB Kinase and Activation of the Mitogen-activated Protein Kinase p38* , 2001, The Journal of Biological Chemistry.
[29] G. Stark,et al. Complex roles of Stat1 in regulating gene expression , 2000, Oncogene.
[30] J. Baldassare,et al. The role of p38 mitogen-activated protein kinase in IL-1 beta transcription. , 1999, Journal of immunology.
[31] G. Haegeman,et al. p38 and Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase Pathways Are Required for Nuclear Factor-κB p65 Transactivation Mediated by Tumor Necrosis Factor* , 1998, The Journal of Biological Chemistry.
[32] F. Hargreave,et al. Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements. , 1996, American journal of respiratory and critical care medicine.