Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1.
暂无分享,去创建一个
[1] R. Evans,et al. An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[2] C. Lieber. CYP2E1: from ASH to NASH. , 2004, Hepatology research : the official journal of the Japan Society of Hepatology.
[3] F Peter Guengerich,et al. Cytochromes P450, drugs, and diseases. , 2003, Molecular interventions.
[4] D. Moore,et al. Induction of bilirubin clearance by the constitutive androstane receptor (CAR) , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[5] F. Guengerich,et al. Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. , 1991, Chemical research in toxicology.
[6] B B Brodie,et al. Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism. , 1973, The Journal of pharmacology and experimental therapeutics.
[7] Effects of alcohol and oxidative stress on liver pathology: the role of the mitochondrion. , 2002, Alcoholism, clinical and experimental research.
[8] A. Salter,et al. Molecular basis of non-responsiveness to peroxisome proliferators: the guinea-pig PPARalpha is functional and mediates peroxisome proliferator-induced hypolipidaemia. , 1998, The Biochemical journal.
[9] F Peter Guengerich,et al. Functional characterization of four allelic variants of human cytochrome P450 1A2. , 2004, Archives of biochemistry and biophysics.
[10] F. Gonzalez,et al. Study of P450 function using gene knockout and transgenic mice. , 2003, Archives of biochemistry and biophysics.
[11] Ai-Ming Yu,et al. Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6. , 2003, Pharmacogenetics.
[12] T. Pineau,et al. Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor , 1995, Science.
[13] D. Moore,et al. The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism , 2000, Nature.
[14] Shelly C. Lu,et al. Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[15] Kenji Nakamura,et al. Loss of teratogenic response to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) in mice lacking the Ah (dioxin) receptor , 1997, Genes to cells : devoted to molecular & cellular mechanisms.
[16] T. Vanhaecke,et al. Hepatocyte cultures in drug metabolism and toxicological research and testing. , 2006, Methods in molecular biology.
[17] R S McCuskey,et al. Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[18] T. Shimada,et al. Purification and characterization of human liver microsomal cytochrome P-450 2A6. , 1991, Molecular pharmacology.
[19] L. Maltais,et al. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. , 2004, Pharmacogenetics.
[20] D. Roop,et al. Disruption of Dihydronicotinamide Riboside:Quinone Oxidoreductase 2 (NQO2) Leads to Myeloid Hyperplasia of Bone Marrow and Decreased Sensitivity to Menadione Toxicity* , 2002, The Journal of Biological Chemistry.
[21] A. Cederbaum,et al. Oxidative stress, toxicology, and pharmacology of CYP2E1. , 2004, Annual review of pharmacology and toxicology.
[22] M. Ingelman-Sundberg,et al. Rat liver microsomal NADPH-supported oxidase activity and lipid peroxidation dependent on ethanol-inducible cytochrome P-450 (P-450IIE1). , 1989, Biochemical pharmacology.
[23] D. Nebert,et al. Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery. , 2000, Biochemical and biophysical research communications.
[24] I. Leclercq,et al. Central role of PPARα‐dependent hepatic lipid turnover in dietary steatohepatitis in mice , 2003, Hepatology.
[25] B. Neuschwander‐Tetri,et al. Humanized xenobiotic response in mice expressing nuclear receptor SXR , 2000, Nature.
[26] T. Shimada,et al. Activation of procarcinogens by human cytochrome P450 enzymes. , 1998, Mutation research.
[27] C. Wolf,et al. Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase Pi. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[28] A. Jaiswal,et al. Disruption of the DT Diaphorase (NQO1) Gene in Mice Leads to Increased Menadione Toxicity* , 1998, The Journal of Biological Chemistry.
[29] W. Chan,et al. Resistance to carbon tetrachloride-induced hepatotoxicity in mice which lack CYP2E1 expression. , 1998, Toxicology and applied pharmacology.
[30] T. Pineau,et al. Role of CYP2E1 in the Hepatotoxicity of Acetaminophen (*) , 1996, The Journal of Biological Chemistry.
[31] P. Watkins,et al. THE HUMAN CYP3A SUBFAMILY: PRACTICAL CONSIDERATIONS* , 2000, Drug metabolism reviews.
[32] M. Ingelman-Sundberg,et al. Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis , 1998, Hepatology.
[33] A. Cederbaum,et al. Stable expression of human cytochrome P4502E1 in HepG2 cells: characterization of catalytic activities and production of reactive oxygen intermediates. , 1993, Biochemistry.
[34] Wen Xie,et al. Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[35] J. Casazza,et al. Identification of ethanol-inducible P-450 isozyme 3a as the acetone and acetol monooxygenase of rabbit microsomes. , 1985, The Journal of biological chemistry.
[36] L. Hui,et al. Association of genetic polymorphisms in CYP2E1, MPO, NQO1, GSTM1, and GSTT1 genes with benzene poisoning. , 2002, Environmental health perspectives.
[37] K. Hensley,et al. Reactive oxygen species and protein oxidation in aging: a look back, a look ahead. , 2002, Archives of biochemistry and biophysics.
[38] D. WuDunn. Genetic basis of glaucoma , 2002, Current opinion in ophthalmology.
[39] C. Wolf,et al. Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[40] J. Reddy,et al. Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[41] I. Leclercq,et al. CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. , 2000, The Journal of clinical investigation.
[42] J. Peters,et al. Mechanism of Action of the Nongenotoxic Peroxisome Proliferators: Role of the Peroxisome Proliferator-Activated Receptor α , 1998 .
[43] N. Chalasani,et al. Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis , 2003, Hepatology.
[44] B B Brodie,et al. Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo. , 1973, The Journal of pharmacology and experimental therapeutics.
[45] M. Czaja,et al. CYP2E1 overexpression alters hepatocyte death from menadione and fatty acids by activation of ERK1/2 signaling , 2004, Hepatology.
[46] J. Matés,et al. Antioxidant enzymes and human diseases. , 1999, Clinical biochemistry.
[47] T. Pineau,et al. Role of CYP1A2 in caffeine pharmacokinetics and metabolism: studies using mice deficient in CYP1A2. , 1996, Pharmacogenetics.
[48] Lang Li,et al. Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans. , 2003, British journal of clinical pharmacology.
[49] F. Gonzalez,et al. Targeted Disruption of Soluble Epoxide Hydrolase Reveals a Role in Blood Pressure Regulation* , 2000, The Journal of Biological Chemistry.
[50] F. Gonzalez,et al. Transgenic models in xenobiotic metabolism and toxicology. , 2002, Toxicology.
[51] H. Forman,et al. Redox signaling and the MAP kinase pathways , 2003, BioFactors.
[52] J M Ward,et al. Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice. , 1998, Toxicology and applied pharmacology.
[53] T. Willson,et al. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[54] K. Korzekwa,et al. Cytochromes P450 Expression Systems , 1995 .
[55] A. Cederbaum,et al. CYP2E1 Overexpression in HepG2 Cells Induces Glutathione Synthesis by Transcriptional Activation of γ-Glutamylcysteine Synthetase* , 2000, The Journal of Biological Chemistry.
[56] J. Goldstein,et al. Mouse Liver CYP2C39 Is a Novel Retinoic Acid 4-Hydroxylase , 2004, Journal of Biological Chemistry.
[57] T. Willson,et al. Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor. , 2002, Journal of lipid research.
[58] G. L. Kedderis,et al. Metabolism of chloroform by cytochrome P450 2E1 is required for induction of toxicity in the liver, kidney, and nose of male mice. , 1999, Toxicology and applied pharmacology.
[59] Y. Liu,et al. Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor. , 2001, Drug metabolism and disposition: the biological fate of chemicals.
[60] I. Leclercq,et al. Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress. , 2001, American journal of physiology. Gastrointestinal and liver physiology.
[61] E. P. Dellinger,et al. CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease , 2003, Hepatology.
[62] K. Mak,et al. Model of nonalcoholic steatohepatitis. , 2004, The American journal of clinical nutrition.
[63] J. Ward,et al. Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[64] P. Valensi,et al. Cytochrome P450 2E1 activity in diabetic and obese patients as assessed by chlorzoxazone hydroxylation , 1998, Fundamental & clinical pharmacology.
[65] F. Gonzalez,et al. Targeted Disruption of the Microsomal Epoxide Hydrolase Gene , 1999, The Journal of Biological Chemistry.
[66] F. Gonzalez,et al. Induction of rat hepatic N-nitrosodimethylamine demethylase by acetone is due to protein stabilization. , 1989, The Journal of biological chemistry.
[67] D. Moore,et al. Modulation of Acetaminophen-Induced Hepatotoxicity by the Xenobiotic Receptor CAR , 2002, Science.
[68] M. Weltman,et al. Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation. , 1996, Gastroenterology.