Role of α-Dystroglycan as a Schwann Cell Receptor for Mycobacterium leprae

a-Dystroglycan (a-DG) is a component of the dystroglycan complex, which is involved in early development and morphogenesis and in the pathogenesis of muscular dystrophies. Here, a-DG was shown to serve as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy. Mycobacterium leprae specifically bound to a-DG only in the presence of the G domain of the a2 chain of laminin-2. Native a-DG competitively inhibited the laminin-2—mediated M. leprae binding to primary Schwann cells. Thus, M. leprae may use linkage between the extracellular matrix and cytoskeleton through laminin-2 and a-DG for its interaction with Schwann cells.

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