Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance
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Yu Li | Michael Roden | Y. Li | M. Roden | A. Marette | F. Tremblay | S. Brûlé | Sung Hee Um | K. Masuda | X. J. Sun | M. Krebs | R. Polakiewicz | George Thomas | Frédéric Tremblay | Michael Krebs | André Marette | Roberto D Polakiewicz | George Thomas | Sophie Brûlé | Sung Hee Um | Kohei Masuda | Xiao Jian Sun | X. Sun | Frédéric Tremblay
[1] Roger Davis,et al. The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307 * , 2000, The Journal of Biological Chemistry.
[2] Tony Hunter,et al. Turnover of the Active Fraction of IRS1 Involves Raptor-mTOR- and S6K1-Dependent Serine Phosphorylation in Cell Culture Models of Tuberous Sclerosis , 2006, Molecular and Cellular Biology.
[3] I. Gout,et al. The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins , 2004, The Journal of cell biology.
[4] E. Kraegen,et al. Development of Muscle Insulin Resistance After Liver Insulin Resistance in High-Fat–Fed Rats , 1991, Diabetes.
[5] Alexandros Tzatsos,et al. Nutrients Suppress Phosphatidylinositol 3-Kinase/Akt Signaling via Raptor-Dependent mTOR-Mediated Insulin Receptor Substrate 1 Phosphorylation , 2006, Molecular and Cellular Biology.
[6] D. Leroith,et al. Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins. , 2001, The Journal of biological chemistry.
[7] T. Hunter,et al. Tuberous Sclerosis and Insulin Resistance: Unlikely Bedfellows Reveal A TORrid Affair , 2005, Cell cycle.
[8] R. Roth,et al. Modulation of Insulin Receptor Substrate-1 Tyrosine Phosphorylation and Function by Mitogen-activated Protein Kinase* , 1997, The Journal of Biological Chemistry.
[9] P. Felig,et al. Plasma amino acid levels and insulin secretion in obesity. , 1970, The New England journal of medicine.
[10] G. Thomas,et al. Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. , 2006, Cell metabolism.
[11] C. Kahn,et al. Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. , 1999, The Journal of clinical investigation.
[12] N. Sonenberg,et al. Upstream and downstream of mTOR. , 2004, Genes & development.
[13] J. Chen,et al. Protein Kinase C-ζ Phosphorylates Insulin Receptor Substrate-1 and Impairs Its Ability to Activate Phosphatidylinositol 3-Kinase in Response to Insulin* , 2001, The Journal of Biological Chemistry.
[14] A. Marette,et al. Activation of the mammalian target of rapamycin pathway acutely inhibits insulin signaling to Akt and glucose transport in 3T3-L1 and human adipocytes. , 2005, Endocrinology.
[15] Peter Nowotny,et al. Mechanism of amino acid-induced skeletal muscle insulin resistance in humans. , 2002, Diabetes.
[16] T. Hunter,et al. Inappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival Deficiencies , 2004, Current Biology.
[17] J. Russell,et al. Identification of Enhanced Serine Kinase Activity in Insulin Resistance* , 1999, The Journal of Biological Chemistry.
[18] A. Marette,et al. Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance. , 2005, Endocrinology.
[19] R. Burcelin,et al. Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice , 2000, Nature.
[20] Jianping Ye,et al. Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex* 210 , 2002, The Journal of Biological Chemistry.
[21] D. Accili. Lilly lecture 2003: the struggle for mastery in insulin action: from triumvirate to republic. , 2004, Diabetes.
[22] O. Shah,et al. 4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle. , 2000, American journal of physiology. Endocrinology and metabolism.
[23] Cristina M Rondinone,et al. Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation. , 2004, Biochemical and biophysical research communications.
[24] M. White,et al. IRS proteins and the common path to diabetes. , 2002, American journal of physiology. Endocrinology and metabolism.
[25] Y. Zick. Insulin resistance: a phosphorylation-based uncoupling of insulin signaling. , 2001, Trends in cell biology.
[26] Stefano Fumagalli,et al. Disruption of the p70s6k/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase , 1998, The EMBO journal.
[27] Peter Nowotny,et al. Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. , 2005, Diabetes.
[28] M. Birnbaum,et al. Protein Kinase C θ Inhibits Insulin Signaling by Phosphorylating IRS1 at Ser1101* , 2004, Journal of Biological Chemistry.
[29] E. Kraegen,et al. Influence of Dietary Fat Composition on Development of Insulin Resistance in Rats: Relationship to Muscle Triglyceride and ω-3 Fatty Acids in Muscle Phospholipid , 1991, Diabetes.
[30] L. S. Harrington,et al. Restraining PI3K: mTOR signalling goes back to the membrane. , 2005, Trends in biochemical sciences.
[31] A. Jaeschke,et al. mTOR: a mediator of intracellular homeostasis. , 2004, Current topics in microbiology and immunology.
[32] G. Thomas,et al. Substrate recognition determinants of the mitogen-activated 70K S6 kinase from rat liver. , 1992, The Journal of biological chemistry.
[33] T. Haruta,et al. Mammalian Target of Rapamycin Pathway Regulates Insulin Signaling via Subcellular Redistribution of Insulin Receptor Substrate 1 and Integrates Nutritional Signals and Metabolic Signals of Insulin , 2001, Molecular and Cellular Biology.
[34] P. Felig. Amino acid metabolism in man. , 1975, Annual review of biochemistry.
[35] A. Marette,et al. Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells. , 2001, The Journal of biological chemistry.
[36] M. Roden,et al. Nutrient-induced insulin resistance in human skeletal muscle. , 2004, Current medicinal chemistry.
[37] G. Thomas,et al. Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling. , 2002, Genes & development.
[38] L. Mayo,et al. A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1 , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[39] E. Hafen,et al. dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1 , 2002, Nature cell biology.
[40] B. Kahn,et al. Glucose transporters and insulin action--implications for insulin resistance and diabetes mellitus. , 1999, The New England journal of medicine.
[41] D. James,et al. Fat feeding causes widespread in vivo insulin resistance, decreased energy expenditure, and obesity in rats. , 1986, The American journal of physiology.
[42] J. Tanti,et al. MAP kinases and mTOR mediate insulin-induced phosphorylation of Insulin Receptor Substrate-1 on serine residues 307, 612 and 632 , 2003, Diabetologia.
[43] Johan Auwerx,et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity , 2004, Nature.
[44] X. Remesar,et al. Muscle amino acid pattern in obese rats , 1997, International Journal of Obesity.
[45] J. Olefsky,et al. A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. , 2000, Molecular endocrinology.