An osteopontin‐derived peptide inhibits human hair growth at least in part by decreasing fibroblast growth factor‐7 production in outer root sheath keratinocytes

Given that unwanted hair growth (hirsutism, hypertrichosis) can cause major psychological distress, new pharmacological treatment strategies with safe and effective hair growth inhibitors that do not destroy the hair follicle (HF) and its stem cells need to be developed.

[1]  Wenping Wang,et al.  Osteopontin activates mesenchymal stem cells to repair skin wound , 2017, PloS one.

[2]  R. Paus,et al.  Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix. , 2017, European journal of cell biology.

[3]  Ran Wei,et al.  Osteopontin -- a promising biomarker for cancer therapy , 2017, Journal of Cancer.

[4]  Anak Khantachawana,et al.  Effect of laser diode light irradiation on growth capability of human hair follicle dermal papilla cells , 2017, 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[5]  Clare L. Garcin,et al.  The battle of the bulge: re‐evaluating hair follicle stem cells in wound repair , 2017, Experimental dermatology.

[6]  C. Moser,et al.  Evaluation of Gene Expression Patterns in Micrografts Demonstrate Induction of Catagen-Like Processes During Storage , 2017, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[7]  Somenath Sarkar,et al.  Long-pulsed Nd: YAG Laser and Intense Pulse Light-755 nm for Idiopathic Facial Hirsutism: A Comparative Study , 2017, Journal of cutaneous and aesthetic surgery.

[8]  R. Azziz,et al.  Androgen excess: Investigations and management. , 2016, Best practice & research. Clinical obstetrics & gynaecology.

[9]  A. Izeta,et al.  Hair follicle-containing punch grafts accelerate chronic ulcer healing: A randomized controlled trial. , 2016, Journal of the American Academy of Dermatology.

[10]  R. Paus,et al.  Thyroid Hormones Enhance Mitochondrial Function in Human Epidermis. , 2016, The Journal of investigative dermatology.

[11]  R. Paus,et al.  The Thyroid Hormone Analogue KB2115 (Eprotirome) Prolongs Human Hair Growth (Anagen) Ex Vivo. , 2016, The Journal of investigative dermatology.

[12]  Ha Rim Kim,et al.  Hominis Placenta facilitates hair re-growth by upregulating cellular proliferation and expression of fibroblast growth factor-7 , 2016, BMC Complementary and Alternative Medicine.

[13]  Z. Fedorowicz,et al.  Interventions for hirsutism excluding laser and photoepilation therapy alone: abridged Cochrane systematic review including GRADE assessments , 2016, The British journal of dermatology.

[14]  Jurgen Müller,et al.  Negative feedback regulation of the ERK1/2 MAPK pathway , 2016, Cellular and Molecular Life Sciences.

[15]  Y. Lim,et al.  Bee Venom Promotes Hair Growth in Association with Inhibiting 5α-Reductase Expression. , 2016, Biological & pharmaceutical bulletin.

[16]  M. Nobakht,et al.  Bulge Hair Follicle Stem Cells Accelerate Cutaneous Wound Healing in Rats. , 2016, Wounds : a compendium of clinical research and practice.

[17]  R. Kirsner,et al.  Optimizing Skin Grafting Using Hair-derived Skin Grafts: The Healing Potential of Hair Follicle Pluripotent Stem Cells. , 2016, Wounds : a compendium of clinical research and practice.

[18]  Jiwang Zhang,et al.  Osteopontin—A Master Regulator of Epithelial-Mesenchymal Transition , 2016, Journal of clinical medicine.

[19]  O. Kwon,et al.  Role of Arachidonic Acid in Promoting Hair Growth , 2016, Annals of dermatology.

[20]  R. Paus,et al.  Human hair follicle organ culture: theory, application and perspectives , 2015, Experimental dermatology.

[21]  Jung Chul Kim,et al.  A guide to studying human hair follicle cycling in vivo , 2015, The Journal of investigative dermatology.

[22]  G. Neri,et al.  Congenital generalized hypertrichosis: the skin as a clue to complex malformation syndromes , 2015, Italian Journal of Pediatrics.

[23]  Jie Yu,et al.  Hair Growth Promotion Activity and Its Mechanism of Polygonum multiflorum , 2015, Evidence-based complementary and alternative medicine : eCAM.

[24]  J. Grant-Kels,et al.  Endocrine evaluation of hirsutism☆ , 2015, International journal of women's dermatology.

[25]  K. Scharffetter-Kochanek,et al.  Osteopontin deficiency affects imiquimod‐induced psoriasis‐like murine skin inflammation and lymphocyte distribution in skin, draining lymph nodes and spleen , 2015, Experimental dermatology.

[26]  A. Izeta,et al.  Reflections on how wound healing‐promoting effects of the hair follicle can be translated into clinical practice , 2015, Experimental dermatology.

[27]  Aditya K. Gupta,et al.  5% Minoxidil: treatment for female pattern hair loss. , 2014, Skin therapy letter.

[28]  N. Somani,et al.  Hirsutism: An Evidence-Based Treatment Update , 2014, American Journal of Clinical Dermatology.

[29]  M. Picardo,et al.  Advanced inhibition of undesired human hair growth by PPARγ modulation? , 2014, The Journal of investigative dermatology.

[30]  R. Paus,et al.  A new humanized mouse model for alopecia areata. , 2013, The journal of investigative dermatology. Symposium proceedings.

[31]  J. Pouwels,et al.  Integrin inactivators: balancing cellular functions in vitro and in vivo , 2013, Nature Reviews Molecular Cell Biology.

[32]  R. Paus,et al.  Neural controls of human hair growth: calcitonin gene-related peptide (CGRP) induces catagen. , 2012, Journal of dermatological science.

[33]  A. Dunaif,et al.  The Hirsute woman: challenges in evaluation and management. , 2011, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.

[34]  R. Paus,et al.  Exploring the "hair growth-wound healing connection": anagen phase promotes wound re-epithelialization. , 2011, The Journal of investigative dermatology.

[35]  R. Paus,et al.  Methods in hair research: how to objectively distinguish between anagen and catagen in human hair follicle organ culture , 2010, Experimental dermatology.

[36]  J. Weiss,et al.  Osteopontin and the skin: multiple emerging roles in cutaneous biology and pathology , 2009, Experimental dermatology.

[37]  Ralf Paus,et al.  The Hair Follicle as a Dynamic Miniorgan , 2009, Current Biology.

[38]  R. Paus,et al.  Immunophenotyping of the human bulge region: the quest to define useful in situ markers for human epithelial hair follicle stem cells and their niche , 2008, Experimental dermatology.

[39]  M. Humphries,et al.  Functional role of β1 integrin-mediated signalling in the human hair follicle , 2008 .

[40]  C. Elmets,et al.  Osteopontin Expression in Normal Skin and Non-melanoma Skin Tumors , 2008, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[41]  L. Liaw,et al.  Osteopontin: A Multifunctional Molecule Regulating Chronic Inflammation and Vascular Disease , 2007, Arteriosclerosis, thrombosis, and vascular biology.

[42]  D. Tobin,et al.  Dissecting the impact of chemotherapy on the human hair follicle: a pragmatic in vitro assay for studying the pathogenesis and potential management of hair follicle dystrophy. , 2007, The American journal of pathology.

[43]  S. Arase,et al.  Adenosine stimulates fibroblast growth factor-7 gene expression via adenosine A2b receptor signaling in dermal papilla cells. , 2007, The Journal of investigative dermatology.

[44]  Tobias Nyström,et al.  A constitutive endogenous osteopontin production is important for macrophage function and differentiation. , 2007, Experimental cell research.

[45]  R. Paus,et al.  Towards the development of a simplified long‐term organ culture method for human scalp skin and its appendages under serum‐free conditions , 2007, Experimental dermatology.

[46]  T. Sun,et al.  Osteopontin gene is expressed in the dermal papilla of pelage follicles in a hair-cycle-dependent manner. , 2001, The Journal of investigative dermatology.

[47]  C Hutter,et al.  Dermal fibroblast-derived growth factors restore the ability of beta(1) integrin-deficient embryonal stem cells to differentiate into keratinocytes. , 2001, Developmental biology.

[48]  M. Xiang,et al.  [Osteopontin of skin and hair follicle of rat]. , 2000, Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae.

[49]  C. Potten,et al.  Keratinocyte growth factor increases hair follicle survival following cytotoxic insult. , 2000, The Journal of investigative dermatology.

[50]  D. Elder,et al.  The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. , 1998, Journal of cell science.

[51]  Carina,et al.  Analysis of apoptosis during hair follicle regression (catagen) , 1997, The American journal of pathology.

[52]  G. Martin,et al.  Fibroblast growth factor signalling in the hair growth cycle: Expression of the fibroblast growth factor receptor and ligand genes in the murine hair follicle , 1996, Developmental dynamics : an official publication of the American Association of Anatomists.

[53]  E. Fuchs,et al.  Keratinocyte growth factor is required for hair development but not for wound healing. , 1996, Genes & development.

[54]  D. Danilenko,et al.  Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu/nu follicular differentiation defect and amelioration of chemotherapy-induced alopecia. , 1995, The American journal of pathology.

[55]  M. Green,et al.  Human hair growth in vitro. , 1990, Journal of cell science.

[56]  R. Heel,et al.  Topical Minoxidil , 1987, Drugs.

[57]  U. Blume-Peytavi.  How to diagnose and treat medically women with excessive hair. , 2013, Dermatologic clinics.

[58]  M. Humphries,et al.  Functional role of beta 1 integrin-mediated signalling in the human hair follicle. , 2008, Experimental cell research.