The relationships among cognition, motivation, and emotion in schizophrenia: how much and how little we know.

This article summarizes a workshop discussion focused on the current state of our understanding of the ways in which cognitive dysfunction in schizophrenia is related to, influenced by, or even leads to disturbances in areas such as emotion, motivation, and stress, as well as areas in need of further research. A major emphasis in the workshop discussion was the critical importance of motivation and its potential influence on cognitive function and learning in schizophrenia. As such, the members of the workshop suggested a number of questions regarding motivation that need further research, including (1) the definition and measurement of different components of motivation; (2) the relationship between intrinsic motivation and incentive drive and hedonic processing; (3) the integrity of motivational processes, incentive drive, and hedonic processing in schizophrenia; (4) the influence of cognitive deficits on motivational disturbances in schizophrenia; (5) the influence of antipsychotic medication on incentive drive and hedonic processing in schizophrenia; and (6) the relationships among cognitive function, stress, and the processing of aversive stimuli.

[1]  P. Meehl.  Schizotaxia, Schizotypy, Schizophrenia , 1962 .

[2]  E. Deci.  Effects of Externally Mediated Rewards on Intrinsic Motivation. , 1971 .

[3]  R. Bolles.  Reinforcement, expectancy, and learning. , 1972 .

[4]  D. Bindra.  How adaptive behavior is produced: a perceptual-motivational alternative to response reinforcements , 1978, Behavioral and Brain Sciences.

[5]  John W. Atkinson,et al.  Studying personality in the context of an advanced motivational psychology. , 1981 .

[6]  A. I. della Rocchetta.  Classification and recall of pictures after unilateral frontal or temporal lobectomy. , 1986, Cortex; a journal devoted to the study of the nervous system and behavior.

[7]  M. Strauss,et al.  Reduction of perseverative errors in patients with schizophrenia using monetary feedback. , 1991, Journal of abnormal psychology.

[8]  S. Ganzell,et al.  Wisconsin Card Sorting Test performance in schizophrenia: remediation of a stubborn deficit. , 1992, The American journal of psychiatry.

[9]  H. Berenbaum,et al.  Emotional experience and expression in schizophrenia and depression. , 1992, Journal of abnormal psychology.

[10]  D. A. Smith,et al.  Flat affect in schizophrenia does not reflect diminished subjective experience of emotion. , 1993, Journal of abnormal psychology.

[11]  C. Carver,et al.  Behavioral inhibition, behavioral activation, and affective responses to impending reward and punishment: The BIS/BAS Scales , 1994 .

[12]  B. Kopp,et al.  Error-correcting behavior in schizophrenic patients , 1994, Schizophrenia Research.

[13]  J. Krystal,et al.  Affective Reactivity of Language in Schizophrenia , 1994, The Journal of nervous and mental disease.

[14]  B. Wexler,et al.  Affective Reactivity of Language in Stable Schizophrenic Outpatients and Their Parents , 1994, The Journal of nervous and mental disease.

[15]  G. Geurtsen,et al.  Durable improvements in Wisconsin card sorting test performance in schizophrenic patients , 1995, Schizophrenia Research.

[16]  M. Green,et al.  Modification of performance on the span of apprehension, a putative marker of vulnerability to schizophrenia. , 1995, Journal of abnormal psychology.

[17]  A. Barto,et al.  Adaptive Critics and the Basal Ganglia , 1994 .

[18]  C. Grillon,et al.  Affective reactivity of language and the startle response in schizophrenia , 1995, Biological Psychiatry.

[19]  A. Kring,et al.  Do schizophrenic patients show a disjunctive relationship among expressive, experiential, and psychophysiological components of emotion? , 1996, Journal of abnormal psychology.

[20]  Y. Lecrubier,et al.  Measures of anhedonia and hedonic responses to sucrose in depressive and schizophrenic patients in comparison with healthy subjects , 1998, European Psychiatry.

[21]  N. Docherty,et al.  Affective reactivity of speech in schizophrenia patients and their nonschizophrenic relatives. , 1998, Journal of abnormal psychology.

[22]  M. Green,et al.  Monetary reinforcement and Wisconsin Card Sorting performance in schizophrenia: Why Show Me the Money? , 1998, Schizophrenia Research.

[23]  Terry E. Goldberg,et al.  Operant conditioning and the orbitofrontal cortex in schizophrenic patients: unexpected evidence for intact functioning , 1998, Schizophrenia Research.

[24]  Andrew J. Tomarkenand,et al.  Frontal Brain Asymmetry and Depression: A Self-regulatory Perspective , 1998 .

[25]  E. Tory Higgins,et al.  Promotion and prevention as a motivational duality: Implications for evaluative processes. , 1999 .

[26]  B. Kopp,et al.  An event-related brain potential substrate of disturbed response monitoring in paranoid schizophrenic patients. , 1999, Journal of abnormal psychology.

[27]  S. Chaiken,et al.  Dual-process theories in social psychology , 1999 .

[28]  C. Curtis,et al.  Acoustic startle reflex in schizophrenia patients and their first-degree relatives: evidence of normal emotional modulation. , 1999, Psychophysiology.

[29]  Eric D. Heggestad,et al.  Individual Differences in Trait Motivation: Development of the Motivational Trait Questionnaire. , 2000 .

[30]  Charles S. Carver,et al.  Action, Emotion, and Personality: Emerging Conceptual Integration , 2000 .

[31]  Dennis R. Combs,et al.  Modification of affect perception deficits in schizophrenia , 2000, Schizophrenia Research.

[32]  Christine A. Taylor.  Enhancing Adult Motivation to Learn , 2000 .

[33]  C. Carter,et al.  Anterior cingulate cortex activity and impaired self-monitoring of performance in patients with schizophrenia: an event-related fMRI study. , 2001, The American journal of psychiatry.

[34]  A. Cohen,et al.  Affective reactivity of language symptoms, startle responding, and inhibition in schizophrenia. , 2001, Journal of abnormal psychology.

[35]  S. Paradiso,et al.  Neural mechanisms of anhedonia in schizophrenia: a PET study of response to unpleasant and pleasant odors. , 2001, JAMA.

[36]  Brian Knutson,et al.  Dissociation of reward anticipation and outcome with event-related fMRI , 2001, Neuroreport.

[37]  E. Higgins,et al.  Achievement orientations from subjective histories of success: Promotion pride versus prevention pride , 2001 .

[38]  E. Deci,et al.  Extrinsic Rewards and Intrinsic Motivation in Education: Reconsidered Once Again , 2001 .

[39]  D. Barch,et al.  Emotional valence and reference disturbance in schizophrenia. , 2002, Journal of abnormal psychology.

[40]  S. Thompson-Schill,et al.  Modulation of Amygdalar Activity by the Conscious Regulation of Negative Emotion , 2002, Journal of Cognitive Neuroscience.

[41]  Claude Alain,et al.  Neurophysiological evidence of error-monitoring deficits in patients with schizophrenia. , 2002, Cerebral cortex.

[42]  K. Kiehl,et al.  Error-related negativity and correct response negativity in schizophrenia , 2002, Clinical Neurophysiology.

[43]  J. Ford,et al.  Response-monitoring dysfunction in schizophrenia: an event-related brain potential study. , 2002, Journal of abnormal psychology.

[44]  J. Gabrieli,et al.  Rethinking Feelings: An fMRI Study of the Cognitive Regulation of Emotion , 2002, Journal of Cognitive Neuroscience.

[45]  Emil Kraepelin,et al.  Dementia praecox and paraphrenia , 2002 .

[46]  K. Kiehl,et al.  Rostral anterior cingulate cortex dysfunction during error processing in schizophrenia. , 2003, Brain : a journal of neurology.

[47]  Samuel M. McClure,et al.  Temporal Prediction Errors in a Passive Learning Task Activate Human Striatum , 2003, Neuron.

[48]  Karl J. Friston,et al.  Temporal Difference Models and Reward-Related Learning in the Human Brain , 2003, Neuron.

[49]  J. Ford,et al.  Are impairments of action monitoring and executive control true dissociative dysfunctions in patients with schizophrenia? , 2003, The American journal of psychiatry.

[50]  K. Berridge.  Motivation concepts in behavioral neuroscience , 2004, Physiology & Behavior.

[51]  D. Barch,et al.  Episodic memory for emotional and nonemotional words in schizophrenia , 2004 .

[52]  W. Schultz.  Neural coding of basic reward terms of animal learning theory, game theory, microeconomics and behavioural ecology , 2004, Current Opinion in Neurobiology.

[53]  F. McGlone,et al.  Dopamine Transmission in the Human Striatum during Monetary Reward Tasks , 2004, The Journal of Neuroscience.

[54]  K. Kiehl,et al.  State dependent changes in error monitoring in schizophrenia. , 2004, Journal of psychiatric research.

[55]  Christopher S. Monk,et al.  Choice selection and reward anticipation: an fMRI study , 2004, Neuropsychologia.

[56]  D. Barch.  The cognitive neuroscience of schizophrenia. , 2005, Annual review of clinical psychology.

[57]  Junghee Lee,et al.  Working memory impairments in schizophrenia: a meta-analysis. , 2005, Journal of abnormal psychology.

[58]  D. Glahn,et al.  Beyond hypofrontality: A quantitative meta‐analysis of functional neuroimaging studies of working memory in schizophrenia , 2005, Human brain mapping.

[59]  J. Gross,et al.  The cognitive control of emotion , 2005, Trends in Cognitive Sciences.

[60]  Keith H. Nuechterlein,et al.  Schizophrenia patients demonstrate a distinctive pattern of decision-making impairment on the Iowa Gambling Task , 2005, Schizophrenia Research.