论文信息 - New MRI findings in Creutzfeldt-Jakob disease: high signal in the globus pallidus on T 1-weighted images

New MRI findings in Creutzfeldt-Jakob disease: high signal in the globus pallidus on T 1-weighted images

Abstract We report a 49-year-old woman with Creutzfeldt-Jakob disease (CJD). In addition to typical high-signal lesions on proton-density and T 2-weighted images there was high signal in the globus pallidus bilaterally on T 1-weighted images. The latter feature has not been described previously and probably due to deposition of prion protein, as found at autopsy.

[1] S. Hori,et al. Portal-systemic encephalopathy: presence of basal ganglia lesions with high signal intensity on MR images. , 1991, Radiology.

[2] J. Provenzale,et al. MR diagnosis of Creutzfeldt-Jakob disease: significance of high signal intensity of the basal ganglia. , 1994, AJR. American journal of roentgenology.

[3] T. Kaji,et al. Atypical MRI features of Wilson's disease: high signal in globus pallidus on T1-weighted images , 1997, Neuroradiology.

[4] R. Henkelman,et al. High signal intensity in MR images of calcified brain tissue. , 1991, Radiology.

[5] I. Zerr,et al. MR imaging of Creutzfeldt-Jakob disease. , 1996, Radiology.

[6] S. Mirowitz,et al. Hyperintense basal ganglia on T1-weighted MR images in patients receiving parenteral nutrition. , 1991, Radiology.

[7] P. Lantos,et al. Prion protein immunocytochemistry – UK five centre consensus report , 1997, Neuropathology and applied neurobiology.

[8] S. Prusiner,et al. Prions and neurodegenerative diseases. , 1987, The New England journal of medicine.

[9] M. Hennerici,et al. Magnetic resonance imaging follow-up in Creutzfeldt-Jakob disease , 1992, Journal of Neurology.

[10] E. Tolosa,et al. Hyperintense globus pallidus on T1‐weighted MRI in cirrhotic patients is associated with severity of liver failure , 1993, Neurology.