In seeking validation of Dissipative Particle Dynamics (DPD) for the mesoscopic modeling of multiphase fluid−fluid systems in external fields, simulations of a pendant drop and a drop in simple shear flow have been performed. The shape profile of the simulated pendant drop was found to be in perfect agreement with that computed by solving the Laplace equation. At increased values of the gravitational force (g), the drop underwent considerable elongation, developing a “neck” between the solid support and its bulk part. Further increases in g resulted in thinning of the neck, which ruptured as g exceeded a certain value, leading to the detachment of the drop. This picture of the detachment process is consistent with the experimental observations published in the literature. Also, the simulations reproduced the drop volume experiment quantitatively. For the drop in shear flow, the degree of deformation was found to be a linear function of the capillary number (Ca) in the region Ca ≤ 0.11, in good agreement w...