The selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expression

[1]  Y. Kan,et al.  Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[2]  G. Heijne.  Membrane-protein topology , 2006, Nature Reviews Molecular Cell Biology.

[3]  Y. ChanJ,et al.  酵母での遺伝的選択によるNF-E2関連転写因子、Nrf1のクローニング , 1993 .

[4]  Peng Zhang,et al.  Characterizing and Modeling the Dynamics of Activity and Popularity , 2013, PloS one.

[5]  J. Hayes,et al.  The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. , 2014, Trends in biochemical sciences.

[6]  Susan C. Farmer,et al.  The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development. , 1997, Genes & development.

[7]  S. Fang,et al.  Live Cell Imaging of Protein Dislocation from the Endoplasmic Reticulum* , 2012, The Journal of Biological Chemistry.

[8]  E. Krüger,et al.  Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop. , 2010, Molecular cell.

[9]  J. Chan,et al.  The Fbw7 Tumor Suppressor Regulates Nuclear Factor E2-related Factor 1 Transcription Factor Turnover through Proteasome-mediated Proteolysis* , 2011, The Journal of Biological Chemistry.

[10]  C. Holmberg,et al.  Specific SKN-1/Nrf Stress Responses to Perturbations in Translation Elongation and Proteasome Activity , 2011, PLoS genetics.

[11]  Masayuki Yamamoto,et al.  Dual Regulation of the Transcriptional Activity of Nrf1 by β-TrCP- and Hrd1-Dependent Degradation Mechanisms , 2011, Molecular and Cellular Biology.

[12]  Yiguo Zhang,et al.  The C-Terminal Domain of Nrf1 Negatively Regulates the Full-Length CNC-bZIP Factor and Its Shorter Isoform LCR-F1/Nrf1β; Both Are Also Inhibited by the Small Dominant-Negative Nrf1γ/δ Isoforms that Down-Regulate ARE-Battery Gene Expression , 2014, PloS one.

[13]  Yong-Yeon Cho,et al.  Ataxia Telangiectasia Mutated Proteins, MAPKs, and RSK2 Are Involved in the Phosphorylation of STAT3* , 2003, The Journal of Biological Chemistry.

[14]  M. Kwak,et al.  Targeting NRF2 signaling for cancer chemoprevention. , 2010, Toxicology and applied pharmacology.

[15]  G. Sykiotis,et al.  Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila. , 2008, Developmental cell.

[16]  Yang Shi,et al.  A Conserved Transcription Motif Suggesting Functional Parallels between Caenorhabditis elegans SKN-1 and Cap‘n’Collar-related Basic Leucine Zipper Proteins* , 2000, The Journal of Biological Chemistry.

[17]  J. Hayes,et al.  Identification of topological determinants in the N-terminal domain of transcription factor Nrf1 that control its orientation in the endoplasmic reticulum membrane. , 2010, The Biochemical journal.

[18]  A. Fukamizu,et al.  Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes. , 2007, The Biochemical journal.

[19]  T. Baumruker,et al.  Nrf1 in a complex with fosB, c-jun, junD and ATF2 forms the AP1 component at the TNF alpha promoter in stimulated mast cells. , 1998, Nucleic acids research.

[20]  I. Arkin,et al.  Interaction and conformational dynamics of membrane‐spanning protein helices , 2009, Protein science : a publication of the Protein Society.

[21]  A. Conney,et al.  Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2. , 2006, Cancer research.

[22]  A. Kolstø,et al.  Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: binding-site selection and regulation of transcription. , 1998, Nucleic acids research.

[23]  G. Ghosh,et al.  The 20S proteasome processes NF‐κB1 p105 into p50 in a translation‐independent manner , 2006, The EMBO journal.

[24]  Candy S. Lee,et al.  Nuclear factor‐erythroid 2‐related factor 1 regulates expression of proteasome genes in hepatocytes and protects against endoplasmic reticulum stress and steatosis in mice , 2013, The FEBS journal.

[25]  H. Aburatani,et al.  Nrf1 and Nrf2 Play Distinct Roles in Activation of Antioxidant Response Element-dependent Genes* , 2008, Journal of Biological Chemistry.

[26]  Masayuki Yamamoto,et al.  The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation. , 2007, The Biochemical journal.

[27]  J. Hayes,et al.  The membrane-topogenic vectorial behaviour of Nrf1 controls its post-translational modification and transactivation activity , 2013, Scientific Reports.

[28]  R. Deshaies,et al.  Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells. , 2010, Molecular cell.

[29]  Y. Kan,et al.  NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[30]  A. Fukamizu,et al.  Central nervous system‐specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction , 2011, Genes to cells : devoted to molecular & cellular mechanisms.

[31]  Jeffrey L. Brodsky,et al.  One step at a time: endoplasmic reticulum-associated degradation , 2008, Nature Reviews Molecular Cell Biology.

[32]  D. Stewart,et al.  Mechanisms underlying chemopreventive effects of flavonoids via multiple signaling nodes within Nrf2-ARE and AhR-XRE gene regulatory networks , 2013 .

[33]  R. Eckert,et al.  A Proteasome Inhibitor-stimulated Nrf1 Protein-dependent Compensatory Increase in Proteasome Subunit Gene Expression Reduces Polycomb Group Protein Level* , 2012, The Journal of Biological Chemistry.

[34]  P. Scambler,et al.  Cloning and mapping of murine Nfe2l1. , 1995, Genomics.

[35]  J. Hayes,et al.  Transcription Factor Nrf1 Is Topologically Repartitioned across Membranes to Enable Target Gene Transactivation through Its Acidic Glucose-Responsive Domains , 2014, PloS one.

[36]  Wei Liu,et al.  CORRIGENDUM: Biodegradation-inspired bioproduction of methylacetoin and 2-methyl-2,3-butanediol , 2013, Scientific Reports.

[37]  X. Chen,et al.  ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. , 2000, Molecular cell.

[38]  J. Chan,et al.  The p65 Isoform of Nrf1 Is a Dominant Negative Inhibitor of ARE-mediated Transcription* , 2007, Journal of Biological Chemistry.

[39]  Tsutomu Ohta,et al.  Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer. , 2006, Molecular cell.

[40]  R. Deshaies,et al.  p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition , 2013, bioRxiv.

[41]  A. Kolstø,et al.  Cellular localisation and nuclear export of the human bZIP transcription factor TCF11. , 2003, Biochimica et biophysica acta.

[42]  Laura Leung,et al.  Deficiency of the Nrf1 and Nrf2 Transcription Factors Results in Early Embryonic Lethality and Severe Oxidative Stress* , 2003, Journal of Biological Chemistry.

[43]  A. Cuadrado,et al.  Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity. , 2012, Oncogene.

[44]  E. Huang,et al.  Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration , 2011, Proceedings of the National Academy of Sciences.

[45]  G. Sykiotis,et al.  Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease , 2010, Science Signaling.

[46]  T. Baumruker,et al.  Nrf1 in a complex with fosB, c-jun, junD and ATF2 forms the AP1 component at the TNF alpha promoter in stimulated mast cells. , 1998, Nucleic acids research.

[47]  William Dowhan,et al.  Lipid-dependent membrane protein topogenesis. , 2009, Annual review of biochemistry.

[48]  K. Itoh,et al.  Dimerization of Substrate Adaptors Can Facilitate Cullin-mediated Ubiquitylation of Proteins by a “Tethering” Mechanism , 2006, Journal of Biological Chemistry.

[49]  T. Rapoport,et al.  Retro-translocation of proteins from the endoplasmic reticulum into the cytosol , 2002, Nature Reviews Molecular Cell Biology.

[50]  C Roland Wolf,et al.  Generation of a stable antioxidant response element-driven reporter gene cell line and its use to show redox-dependent activation of nrf2 by cancer chemotherapeutic agents. , 2006, Cancer research.

[51]  A. Goldberg,et al.  Proteasome-Mediated Processing of Nrf1 Is Essential for Coordinate Induction of All Proteasome Subunits and p97 , 2014, Current Biology.

[52]  J. D. Engel,et al.  Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. , 1999, Genes & development.

[53]  A. Kolstø,et al.  Two Domains of the Human bZIP Transcription Factor TCF11 Are Necessary for Transactivation* , 2001, The Journal of Biological Chemistry.

[54]  M. Auer,et al.  A novel splice variant of the transcription factor Nrf1 interacts with the TNFalpha promoter and stimulates transcription. , 1998, Nucleic acids research.

[55]  Candy S. Lee,et al.  Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[56]  S. Mohan,et al.  Targeted disruption of nuclear factor erythroid-derived 2-like 1 in osteoblasts reduces bone size and bone formation in mice. , 2010, Physiological genomics.

[57]  A. Kolstø,et al.  Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1. , 1996, Nucleic acids research.

[58]  E Yoshida,et al.  Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription , 2001, Genes to cells : devoted to molecular & cellular mechanisms.

[59]  Masayuki Yamamoto,et al.  Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum. , 2006, The Biochemical journal.

[60]  K. Römisch.  Endoplasmic reticulum-associated degradation. , 2005, Annual review of cell and developmental biology.

[61]  B. E. Black,et al.  Retrotranslocation of the Chaperone Calreticulin from the Endoplasmic Reticulum Lumen to the Cytosol , 2005, Molecular and Cellular Biology.

[62]  Masayuki Yamamoto,et al.  The Nrf3 Transcription Factor Is a Membrane-bound Glycoprotein Targeted to the Endoplasmic Reticulum through Its N-terminal Homology Box 1 Sequence* , 2009, Journal of Biological Chemistry.

[63]  E. Nishida,et al.  The Casein Kinase 2-Nrf1 Axis Controls the Clearance of Ubiquitinated Proteins by Regulating Proteasome Gene Expression , 2013, Molecular and Cellular Biology.

[64]  M. Andersen,et al.  Long Isoforms of NRF1 Contribute to Arsenic-Induced Antioxidant Response in Human Keratinocytes , 2010, Environmental health perspectives.

[65]  Bin Tean Teh,et al.  Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer , 2014, eLife.

[66]  A. Kolstø,et al.  Molecular cloning of a putative novel human bZIP transcription factor on chromosome 17q22. , 1994, Genomics.

[67]  Weiya Ma,et al.  Involvement of the Acid Sphingomyelinase Pathway in UVA-induced Apoptosis* , 2001, The Journal of Biological Chemistry.

[68]  Y. Kan,et al.  Targeted disruption of the ubiquitous CNC‐bZIP transcription factor, Nrf‐1, results in anemia and embryonic lethality in mice , 1998, The EMBO journal.

[69]  Ting Huang,et al.  The Nrf1 CNC-bZIP Protein Is Regulated by the Proteasome and Activated by Hypoxia , 2011, PloS one.

[70]  Y. Kan,et al.  The CNC Basic Leucine Zipper Factor, Nrf1, Is Essential for Cell Survival in Response to Oxidative Stress-inducing Agents , 1999, The Journal of Biological Chemistry.

[71]  Michael O. Kelleher,et al.  Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents. , 2009, Toxicology and applied pharmacology.

[72]  P. Young,et al.  Basic Leucine Zipper Protein Cnc-C Is a Substrate and Transcriptional Regulator of the Drosophila 26S Proteasome , 2010, Molecular and Cellular Biology.

[73]  J. Hayes,et al.  The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by t-butyl hydroquinone but not by endoplasmic reticulum stressors. , 2009, The Biochemical journal.

[74]  T. Townes,et al.  Cloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expression. , 1994, Nucleic acids research.