Imaging of 99mTc-DMSA and 18F-FDG in humans using a Si/CdTe Compton camera

OBJECTIVE The Compton camera can simultaneously acquire images of multiple isotopes injected in a body; therefore, it has the potential to introduce a new subfield in the field of biomedical imaging applications. The objective of this study is to assess the ability of a prototype semiconductor-based silicon/cadmium telluride (Si/CdTe) Compton camera to simultaneously capture the distributions of technetium (99mTc)-dimercaptosuccinic acid (DMSA) (141 keV emission) and 18F-fluorodeoxyglucose (FDG) (511 keV emission) injected into a human volunteer. Methods: 99mTc-DMSA and 18F-FDG are injected intravenously into a 25-year-old male volunteer. The distributions of 99mTc-DMSA and 18F-FDG are simultaneously visualized by setting a specified energy window for each radioisotope. The images of these radiopharmaceuticals acquired using the prototype Compton camera are superimposed onto computed tomography images for reference. Results: The reconstructed image showed that 99mTc-DMSA had accumulates in both kidneys, which is consistent with the well-known diagnostic distribution determined by clinical imaging via single-photon emission computed tomography. In the 18F-FDG image, there is broad distribution around the liver and kidneys, which was expected based on routine clinical positron emission tomography imaging. Conclusions: To the best of our knowledge, for the first time, the current study demonstrates first time that the Si/CdTe Compton camera is capable of simultaneously imaging the distributions of two radiopharmaceuticals, 99mTc-DMSA and 18F-FDG, in a human body. These results suggest that the Si/CdTe Compton camera has the potential to become a novel modality for nuclear medical diagnoses enabling multi-probe simultaneous tracking. .

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