SUMO1 modification of KHSRP regulates tumorigenesis by preventing the TL-G-Rich miRNA biogenesis

[1]  Mark S. Litwin,et al.  The Diagnosis and Treatment of Prostate Cancer: A Review , 2017, JAMA.

[2]  Qin Chen,et al.  K259-SUMOylation of DGCR8 promoted by p14ARF exerts a tumor-suppressive function. , 2016, Journal of molecular cell biology.

[3]  Qin Chen,et al.  miR186 suppresses prostate cancer progression by targeting Twist1 , 2016, Oncotarget.

[4]  R. Deng,et al.  SUMOylation of TARBP2 regulates miRNA/siRNA efficiency , 2015, Nature Communications.

[5]  E. Yeh,et al.  A Critical SUMO1 Modification of LKB1 Regulates AMPK Activity during Energy Stress. , 2015, Cell reports.

[6]  Qin Chen,et al.  SUMOylation at K707 of DGCR8 controls direct function of primary microRNA , 2015, Nucleic acids research.

[7]  Qin Chen,et al.  Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma development , 2015, Oncotarget.

[8]  A. Belfiore,et al.  Novel Aspects Concerning the Functional Cross-Talk between the Insulin/IGF-I System and Estrogen Signaling in Cancer Cells , 2015, Front. Endocrinol..

[9]  Jennifer A. Doudna,et al.  Dicer-TRBP complex formation ensures accurate mammalian microRNA biogenesis. , 2015, Molecular cell.

[10]  Qin Chen,et al.  miR‐146a functions as a tumor suppressor in prostate cancer by targeting Rac1 , 2014, The Prostate.

[11]  Qin Chen,et al.  Atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors , 2014, Oncotarget.

[12]  A. Ramos,et al.  KSRP controls pleiotropic cellular functions. , 2014, Seminars in cell & developmental biology.

[13]  H. Kolb,et al.  The clinical importance of assessing tumor hypoxia: relationship of tumor hypoxia to prognosis and therapeutic opportunities. , 2014, Antioxidants & redox signaling.

[14]  P. Febbo,et al.  A 17-gene assay to predict prostate cancer aggressiveness in the context of Gleason grade heterogeneity, tumor multifocality, and biopsy undersampling. , 2014, European urology.

[15]  M. Gorospe,et al.  Destabilization of Nucleophosmin mRNA by the HuR/KSRP complex is required for muscle fiber formation , 2014, Nature Communications.

[16]  Qin Chen,et al.  SUMOylation of Grb2 enhances the ERK activity by increasing its binding with Sos1 , 2014, Molecular Cancer.

[17]  C. Futter,et al.  EGF receptor trafficking: consequences for signaling and cancer , 2014, Trends in cell biology.

[18]  A. Santiago,et al.  p53 SUMOylation promotes its nuclear export by facilitating its release from the nuclear export receptor CRM1 , 2013, Molecular biology of the cell.

[19]  G. Strous,et al.  SUMOylation is a regulator of the translocation of Jak2 between nucleus and cytosol. , 2013, The Biochemical journal.

[20]  F. Melchior,et al.  Sumoylation: a regulatory protein modification in health and disease. , 2013, Annual review of biochemistry.

[21]  David H. Mathews,et al.  RNAstructure: web servers for RNA secondary structure prediction and analysis , 2013, Nucleic Acids Res..

[22]  Stephen T. C. Wong,et al.  Genome-Wide RNAi Screening Identifies Genes Inhibiting the Migration of Glioblastoma Cells , 2013, PloS one.

[23]  Xia Li,et al.  RNA-induced silencing complex (RISC) Proteins PACT, TRBP, and Dicer are SRA binding nuclear receptor coregulators , 2013, Proceedings of the National Academy of Sciences.

[24]  H. Shih,et al.  Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response , 2013, The EMBO journal.

[25]  Yanlin Ma,et al.  Sumoylation regulates nuclear localization and function of zinc finger transcription factor ZIC3. , 2012, Biochimica et biophysica acta.

[26]  Terry D. Lee,et al.  Sumoylation of SAE2 C Terminus Regulates SAE Nuclear Localization* , 2012, The Journal of Biological Chemistry.

[27]  G. Nicastro,et al.  Non-canonical Guanine recognition mediates KSRP regulation of Let-7 biogenesis , 2012, Nature Structural &Molecular Biology.

[28]  M. Hendrix,et al.  Tumor cell vasculogenic mimicry: from controversy to therapeutic promise. , 2012, The American journal of pathology.

[29]  Jian Huang,et al.  Identification of microRNA transcriptome involved in human natural killer cell activation. , 2012, Immunology letters.

[30]  Jian Zhang,et al.  SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane , 2012, Nature Communications.

[31]  Jørgen Kjems,et al.  miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA , 2011, The EMBO journal.

[32]  D. Tavian,et al.  Coordinated Sumoylation and Ubiquitination Modulate EGF Induced EGR1 Expression and Stability , 2011, PloS one.

[33]  Xiongbin Lu,et al.  The ATM kinase induces microRNA biogenesis in the DNA damage response. , 2011, Molecular cell.

[34]  A. Ramos,et al.  The role of KSRP in mRNA decay and microRNA precursor maturation , 2010, Wiley interdisciplinary reviews. RNA.

[35]  J. Cáceres,et al.  Antagonistic role of hnRNP A1 and KSRP in the regulation of Let-7a biogenesis , 2010, Nature Structural &Molecular Biology.

[36]  M. Rosenfeld,et al.  The RNA-binding Protein KSRP Promotes the Biogenesis of a Subset of miRNAs , 2016 .

[37]  Geoff Kelly,et al.  Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding , 2009, Nature Structural &Molecular Biology.

[38]  T. Mustelin,et al.  PTEN regulation by Akt–EGR1–ARF–PTEN axis , 2009, The EMBO journal.

[39]  F. Slack,et al.  let-7 microRNAs in development, stem cells and cancer. , 2008, Trends in molecular medicine.

[40]  J. Lieberman,et al.  let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells , 2007, Cell.

[41]  A. Ganesan,et al.  Broad spectrum identification of SUMO substrates in melanoma cells , 2007, Proteomics.

[42]  T. Golub,et al.  Impaired microRNA processing enhances cellular transformation and tumorigenesis , 2007, Nature Genetics.

[43]  A. Dejean,et al.  C-terminal modifications regulate MDM2 dissociation and nuclear export of p53 , 2007, Nature Cell Biology.

[44]  R. Shiekhattar,et al.  TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing , 2005, Nature.

[45]  R. Shiekhattar,et al.  The Microprocessor complex mediates the genesis of microRNAs , 2004, Nature.

[46]  Sanghyuk Lee,et al.  MicroRNA genes are transcribed by RNA polymerase II , 2004, The EMBO journal.

[47]  M. Karin,et al.  A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery. , 2004, Molecular cell.

[48]  B. Cullen,et al.  Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. , 2003, Genes & development.

[49]  D. Black,et al.  Differentiation-induced colocalization of the KH-type splicing regulatory protein with polypyrimidine tract binding protein and the c-src pre-mRNA. , 2003, Molecular biology of the cell.

[50]  D L Black,et al.  A new regulatory protein, KSRP, mediates exon inclusion through an intronic splicing enhancer. , 1997, Genes & development.

[51]  F. Melchior,et al.  A Small Ubiquitin-Related Polypeptide Involved in Targeting RanGAP1 to Nuclear Pore Complex Protein RanBP2 , 1997, Cell.

[52]  G. Blobel,et al.  A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex , 1996, The Journal of cell biology.

[53]  Yan Zhang,et al.  A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. , 2004, Nature genetics.