Clozapine: A Mimicry of Phaeochromocytoma

Objective: To report a case of clozapine-induced hypertension with raised urinary catecholamines. Clinical picture: A 27–year-old man fulfilling DSM-Ill-R criteria for catatonic schizophrenia was treated with clozapine. He later developed both hypertension and raised urinary catecholamines which mimicked phaeochromocytoma. Treatment: Clozapine was withdrawn. Outcome: Both blood pressure and urinary catecholamines normalised. Conclusions: Clozapine may induce sympathetic hyperactivity.