Invasive Haemophilus influenzae disease caused by non-type b strains in Northwestern Ontario, Canada, 2002-2008.

A high incidence of invasive non-type b Haemophilus influenzae disease was found in Northwestern Ontario, Canada; H. influenzae type a was the most prevalent serotype (42%). Clinical and demographic analyses indicate that aboriginal children aged <5 years and adults with predisposing medical conditions are the most affected by invasive H. influenzae disease in the post-H. influenzae vaccine era.

[1]  Kristen R. DeSanto.  Public Health Agency of Canada , 2011 .

[2]  W. Moss,et al.  Haemophilus influenzae type b conjugate vaccine use and effectiveness. , 2008, The Lancet. Infectious diseases.

[3]  S. Deeks,et al.  Invasive Bacterial Diseases in Northern Canada , 2008, Emerging infectious diseases.

[4]  B. Larke,et al.  Epidemiology of Haemophilus influenzae Serotype a, North American Arctic, 2000–2005 , 2008, Emerging infectious diseases.

[5]  S. Halperin,et al.  Invasive Infections Caused by Haemophilus influenzae Serotypes in Twelve Canadian IMPACT Centers, 1996–2001 , 2007, The Pediatric infectious disease journal.

[6]  R. Tsang.  Capsule switching and capsule replacement in vaccine-preventable bacterial diseases. , 2007, The Lancet. Infectious diseases.

[7]  J. Wylie,et al.  Characterization of invasive Haemophilus influenzae disease in Manitoba, Canada, 2000-2006: invasive disease due to non-type b strains. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[8]  M. Dworkin,et al.  The Changing Epidemiology of Invasive Haemophilus influenzae Disease, Especially in Persons ⩾65 Years Old , 2007 .

[9]  L. Hammitt,et al.  The Alaska Haemophilus influenzae Type b Experience: Lessons in Controlling a Vaccine-Preventable Disease , 2006, Pediatrics.

[10]  K. O'Brien,et al.  Epidemiology of invasive Haemophilus influenzae type A disease among Navajo and White Mountain Apache children, 1988-2003. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[11]  K. Yuen,et al.  Characterization of Haemophilus segnis, an Important Cause of Bacteremia, by 16S rRNA Gene Sequencing , 2004, Journal of Clinical Microbiology.

[12]  E. Moxon,et al.  Non-type b Haemophilus influenzae disease: clinical and epidemiologic characteristics in the Haemophilus influenzae type b vaccine era. , 2001, The Pediatric infectious disease journal.

[13]  A. Feeney,et al.  A defective Vkappa A2 allele in Navajos which may play a role in increased susceptibility to haemophilus influenzae type b disease. , 1996, The Journal of clinical investigation.

[14]  W. Heyward,et al.  Limited efficacy of a Haemophilus influenzae type b conjugate vaccine in Alaska Native infants. The Alaska H. influenzae Vaccine Study Group. , 1990, The New England journal of medicine.

[15]  L. Nicolle,et al.  Haemophilus influenzae meningitis in Manitoba and the Keewatin District, NWT: potential for mass vaccination. , 1988, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

[16]  G. Losonsky,et al.  Haemophilus influenzae disease in the White Mountain Apaches: molecular epidemiology of a high risk population. , 1984, Pediatric infectious disease.

[17]  M. Pittman.  VARIATION AND TYPE SPECIFICITY IN THE BACTERIAL SPECIES HEMOPHILUS INFLUENZAE , 1931, The Journal of experimental medicine.

[18]  M. Dworkin,et al.  The changing epidemiology of invasive Haemophilus influenzae disease, especially in persons > or = 65 years old. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[19]  M. Petersen,et al.  Prevention of Haemophilus influenzae type b (Hib) meningitis and emergence of serotype replacement with type a strains after introduction of Hib immunization in Brazil. , 2003, The Journal of infectious diseases.