Antiangiogenic activity of phthalides-enriched Angelica Sinensis extract by suppressing WSB-1/pVHL/HIF-1α/VEGF signaling in bladder cancer

[1]  Hui Ma,et al.  Z-ligustilide restores tamoxifen sensitivity of ERα negative breast cancer cells by reversing MTA1/IFI16/HDACs complex mediated epigenetic repression of ERα , 2017, Oncotarget.

[2]  P. Marsden,et al.  Expression in Cardiac Myocytes In Vitro and In Vivo p 38 MAP Kinase Signaling Cascade Regulates Cyclooxygenase-2 − MAP Kinase Kinase 6 , 2003 .

[3]  Liewei Wang,et al.  WSB1 promotes tumor metastasis by inducing pVHL degradation , 2015, Genes & development.

[4]  Wei Li,et al.  HIF-1α pathway: role, regulation and intervention for cancer therapy , 2015, Acta pharmaceutica Sinica. B.

[5]  A. Zimna,et al.  Hypoxia-Inducible Factor-1 in Physiological and Pathophysiological Angiogenesis: Applications and Therapies , 2015, BioMed research international.

[6]  S. Movafagh,et al.  Regulation of Hypoxia‐Inducible Factor‐1a by Reactive Oxygen Species : New Developments in an Old Debate , 2015, Journal of cellular biochemistry.

[7]  E. Maher,et al.  VHL, the story of a tumour suppressor gene , 2014, Nature Reviews Cancer.

[8]  Xue-feng Xiao,et al.  Phytochemical and pharmacological studies on Radix Angelica sinensis: Phytochemical and pharmacological studies on Radix Angelica sinensis , 2014 .

[9]  Sabita Roy,et al.  Vascular Endothelial Growth Factor Signaling in Hypoxia and Inflammation , 2014, Journal of Neuroimmune Pharmacology.

[10]  Xue-feng Xiao,et al.  Phytochemical and pharmacological studies on Radix Angelica sinensis. , 2013, Chinese journal of natural medicines.

[11]  Jian-jun Zhang,et al.  HIF1 regulates WSB‐1 expression to promote hypoxia‐induced chemoresistance in hepatocellular carcinoma cells , 2013, FEBS letters.

[12]  P. Vlachostergios,et al.  Erratum to: Bortezomib represses HIF-1α protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells , 2013, Journal of Molecular Medicine.

[13]  B. Baradaran,et al.  Tumor angiogenesis and anti-angiogenic therapies. , 2013, Human antibodies.

[14]  G. Lin,et al.  Metabolic conversion from co-existing ingredient leading to significant systemic exposure of Z-butylidenephthalide, a minor ingredient in Chuanxiong Rhizoma in rats. , 2012, Current drug metabolism.

[15]  Rachelle S. Singleton,et al.  The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity , 2012, EMBO reports.

[16]  Bi-Fong Lin,et al.  Bioactivities of major constituents isolated from Angelica sinensis (Danggui) , 2011, Chinese medicine.

[17]  D. Charnock-Jones,et al.  The natural compound n-butylidenephthalide derived from the volatile oil of Radix Angelica sinensis inhibits angiogenesis in vitro and in vivo , 2011, Angiogenesis.

[18]  P. Vlachostergios,et al.  Bortezomib represses HIF-1α protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells , 2011, Journal of Molecular Medicine.

[19]  A. Giaccia,et al.  PHD2 in tumour angiogenesis , 2010, British Journal of Cancer.

[20]  F. Yaǵci,et al.  Evaluation of relationship between HIF-1α immunoreactivity and stage, grade, angiogenic profile and proliferative index in bladder urothelial carcinomas , 2010, International Urology and Nephrology.

[21]  Frédéric Dayan,et al.  Gene regulation in response to graded hypoxia: the non-redundant roles of the oxygen sensors PHD and FIH in the HIF pathway. , 2009, Journal of theoretical biology.

[22]  C. Cho,et al.  Study of the anti-proliferative effects and synergy of phthalides from Angelica sinensis on colon cancer cells. , 2008, Journal of ethnopharmacology.

[23]  J. Dagorn,et al.  The WSB1 Gene Is Involved in Pancreatic Cancer Progression , 2008, PloS one.

[24]  G. Lin,et al.  Pharmacokinetics and Metabolism of Ligustilide, a Major Bioactive Component in Rhizoma Chuanxiong, in the Rat , 2008, Drug Metabolism and Disposition.

[25]  Y. Kwan,et al.  The angiogenic effects of Angelica sinensis extract on HUVEC in vitro and zebrafish in vivo , 2008, Journal of cellular biochemistry.

[26]  J. Shim,et al.  Optimized conditions for the extraction of secondary volatile metabolites in Angelica roots by accelerated solvent extraction. , 2007, Journal of pharmaceutical and biomedical analysis.

[27]  T. Yi,et al.  A new procedure for the preparative separation and isolation of Z-ligustilide from the roots of Angelica sinensis. , 2007, Journal of separation science.

[28]  J. Pouysségur,et al.  The role of the hypoxia-inducible factor in tumor metabolism growth and invasion. , 2006, Bulletin du cancer.

[29]  L. Claesson‐Welsh,et al.  VEGF receptor signalling ? in control of vascular function , 2006, Nature Reviews Molecular Cell Biology.

[30]  L. Ellis,et al.  Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[31]  H. Harn,et al.  Acetone extract of Angelica sinensis inhibits proliferation of human cancer cells via inducing cell cycle arrest and apoptosis. , 2004, Life sciences.

[32]  A. Giaccia,et al.  Hypoxic gene expression and metastasis , 2004, Cancer and Metastasis Reviews.

[33]  G. Semenza Targeting HIF-1 for cancer therapy , 2003, Nature Reviews Cancer.

[34]  P Vaupel,et al.  Biological consequences of tumor hypoxia. , 2001, Seminars in oncology.

[35]  P. Carmeliet,et al.  Angiogenesis in cancer and other diseases , 2000, Nature.

[36]  K. Ko,et al.  Myocardial protection against ischaemia‐ reperfusion injury by a Polygonum multiflorum extract supplemented ‘Dang‐Gui decoction for enriching blood’, a compound formulation, ex vivo , 2000, Phytotherapy research : PTR.

[37]  G. Semenza HIF-1: mediator of physiological and pathophysiological responses to hypoxia. , 2000, Journal of applied physiology.

[38]  D A Hilton,et al.  Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. , 1999, Cancer research.

[39]  A. Harris,et al.  Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. , 1997, Proceedings of the National Academy of Sciences of the United States of America.