In vitro and In vivo Efficacy of Antifungal Agents against Acremonium sp.

Acremonium sp. NJM 0672, isolated from diseased mantis shrimp Oratosquilla oratoria, was susceptible in vitro to three kinds of antifungal agents: voriconazole, amphotericin B and terbinafine hydrochloride. Voriconazole was selected to treat kuruma prawn Penaeus japonicus, which had been intramuscularly injected with 0.1 mL of 5.0 × 104 conidia/mL of Acremonium sp. Voriconazole was administered orally at doses of 6 and 2 mg/kg body weight per day for 7 consecutive days, or intramuscularly injected at doses of 4 and 2 mg/kg body weight per day for 3 consecutive days. Both treatments were begun at 6 h after injection of the conidial suspension. The gross features, mortality and histopathological findings demonstrated that voriconazole was an efficient antifungal agent against Acremonium sp.

[1]  P. Duc,et al.  Pathogenicity of Anamorphic Fungi Plectosporium oratosquillae and Acremonium sp. to Mantis Shrimp Oratosquilla oratoria , 2009 .

[2]  S. Udagawa,et al.  Fungal Infection of Mantis Shrimp (Oratosquilla oratoria) Caused by Two Anamorphic Fungi Found in Japan , 2009, Mycopathologia.

[3]  W. Mieler,et al.  Voriconazole in the treatment of fungal eye infections: a review of current literature , 2008, British Journal of Ophthalmology.

[4]  Clinical,et al.  Reference method for broth dilution antifungal susceptibility testing of filamentous fungi : Approved standard , 2008 .

[5]  H. Schlamm,et al.  Voriconazole as therapy for systemic Penicillium marneffei infections in AIDS patients. , 2007, The American journal of tropical medicine and hygiene.

[6]  W. Sponsel,et al.  Topical Voriconazole as a Novel Treatment for Fungal Keratitis , 2006, Antimicrobial Agents and Chemotherapy.

[7]  H. Yamaguchi,et al.  In vitro antifungal activity of luliconazole against clinical isolates from patients with dermatomycoses , 2006, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

[8]  H. Yamaguchi,et al.  Comparative Evaluation of Standard Dilution Method and Commercial Kit for Frozen Plate Antifungal Susceptibility Testing of Yeasts Using 200 Clinical Isolates , 2004, Microbiology and immunology.

[9]  M. Tarczyńska,et al.  Increase of crustacean sensitivity to purified hepatotoxic cyanobacterial extracts by manipulation of experimental conditions , 2004, Environmental toxicology.

[10]  J. Guarro,et al.  In Vitro Activities of New Antifungal Agents against Chaetomium spp. and Inoculum Standardization , 2003, Antimicrobial Agents and Chemotherapy.

[11]  G. S. de Hoog,et al.  In vitro activity of amphotericin B and itraconazole in combination with flucytosine, sulfadiazine and quinolones against Exophiala spinifera. , 2003, The Journal of antimicrobial chemotherapy.

[12]  H. Vanden Bossche,et al.  Antifungal agents of use in animal health--practical applications. , 2003, Journal of veterinary pharmacology and therapeutics.

[13]  H. Yamaguchi,et al.  In Vitro and In Vivo Activities of CS-758 (R-120758), a New Triazole Antifungal Agent , 2002, Antimicrobial Agents and Chemotherapy.

[14]  A. Espinel-Ingroff.  In Vitro Fungicidal Activities of Voriconazole, Itraconazole, and Amphotericin B against Opportunistic Moniliaceous and Dematiaceous Fungi , 2001, Journal of Clinical Microbiology.

[15]  M. Mcginnis,et al.  In Vitro Testing of Susceptibilities of Filamentous Ascomycetes to Voriconazole, Itraconazole, and Amphotericin B, with Consideration of Phylogenetic Implications , 1998, Journal of Clinical Microbiology.

[16]  M. Domingo,et al.  Cutaneous hyalohyphomycosis caused by Fusarium solani in a loggerhead sea turtle (Caretta caretta L.) , 1997, Journal of clinical microbiology.

[17]  S. Egusa,et al.  Studies on the fungal diseases in crustaceans. I. Lagenidium scyllae sp. nov. isolated from cultivated ova and larvae of the mangrove crab (Scylla serrata). , 1979 .