Interactions between a Pore-Blocking Peptide and the Voltage Sensor of the Sodium Channel: An Electrostatic Approach to Channel Geometry

[1]  E. Isacoff,et al.  Direct Physical Measure of Conformational Rearrangement Underlying Potassium Channel Gating , 1996, Science.

[2]  J. Patlak,et al.  Transfer of twelve charges is needed to open skeletal muscle Na+ channels , 1995, The Journal of general physiology.

[3]  H. Fozzard,et al.  A mu-conotoxin-insensitive Na+ channel mutant: possible localization of a binding site at the outer vestibule. , 1995, Biophysical journal.

[4]  R. Horn,et al.  Evidence for voltage-dependent S4 movement in sodium channels , 1995, Neuron.

[5]  Christopher Miller,et al.  The charybdotoxin receptor of a Shaker K+ channel: Peptide and channel residues mediating molecular recognition , 1994, Neuron.

[6]  I. Mintz.  Block of Ca channels in rat central neurons by the spider toxin omega- Aga-IIIA , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[7]  F J Sigworth,et al.  Voltage gating of ion channels , 1994, Quarterly Reviews of Biophysics.

[8]  D. Kohda,et al.  Structure-activity relationships of mu-conotoxin GIIIA: structure determination of active and inactive sodium channel blocker peptides by NMR and simulated annealing calculations. , 1994, Biochemistry.

[9]  R. French,et al.  Dissecting lidocaine action: diethylamide and phenol mimic separate modes of lidocaine block of sodium channels from heart and skeletal muscle. , 1993, Biophysical journal.

[10]  R. Horn,et al.  Panning transfected cells for electrophysiological studies. , 1993, BioTechniques.

[11]  R. Gordon,et al.  Action of derivatives of mu-conotoxin GIIIA on sodium channels. Single amino acid substitutions in the toxin separately affect association and dissociation rates. , 1992, Biochemistry.

[12]  C. Park,et al.  Mapping function to structure in a channel-blocking peptide: electrostatic mutants of charybdotoxin. , 1992, Biochemistry.

[13]  W. Stühmer,et al.  Calcium channel characteristics conferred on the sodium channel by single mutations , 1992, Nature.

[14]  H. Guy,et al.  Atomic scale structure and functional models of voltage-gated potassium channels. , 1992, Biophysical journal.

[15]  M. Tanouye,et al.  The size of gating charge in wild-type and mutant Shaker potassium channels. , 1992, Science.

[16]  D. Kohda,et al.  Active site of mu-conotoxin GIIIA, a peptide blocker of muscle sodium channels. , 1991, The Journal of biological chemistry.

[17]  R Latorre,et al.  Ion permeation in normal and batrachotoxin-modified Na+ channels in the squid giant axon , 1991, The Journal of general physiology.

[18]  H. Guy,et al.  Pursuing the structure and function of voltage-gated channels , 1990, Trends in Neurosciences.

[19]  W. Stühmer,et al.  A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II , 1989, FEBS letters.

[20]  J. Trimmer,et al.  Primary structure and functional expression of a mammalian skeletal muscle sodium channel , 1989, Neuron.

[21]  F. Conti,et al.  Structural parts involved in activation and inactivation of the sodium channel , 1989, Nature.

[22]  Christopher Miller.  Competition for block of a Ca2+-activated K+ channel by charybdotoxin and tetraethylammonium , 1988, Neuron.

[23]  W. Catterall,et al.  Structure and function of voltage-sensitive ion channels. , 1988, Science.

[24]  R. French,et al.  Effects of membrane surface charge and calcium on the gating of rat brain sodium channels in planar bilayers [published erratum appears in J Gen Physiol 1989 Apr;93(4):following 760] , 1988, The Journal of general physiology.

[25]  S. Hall,et al.  Kinetic basis for insensitivity to tetrodotoxin and saxitoxin in sodium channels of canine heart and denervated rat skeletal muscle. , 1987, Biochemistry.

[26]  William A. Catterall,et al.  Voltage-dependent gating of sodium channels: correlating structure and function , 1986, Trends in Neurosciences.

[27]  H. Takeshima,et al.  Existence of distinct sodium channel messenger RNAs in rat brain , 1986, Nature.

[28]  R. Greenblatt,et al.  The structure of the voltage‐sensitive sodium channel , 1985, FEBS letters.

[29]  D. Yoshikami,et al.  Conus geographus toxins that discriminate between neuronal and muscle sodium channels. , 1985, The Journal of biological chemistry.

[30]  T. Narahashi,et al.  Modification of single Na+ channels by batrachotoxin. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[31]  G. Ehrenstein,et al.  Batrachotoxin modifies the gating kinetics of sodium channels in internally perfused neuroblastoma cells. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[32]  F. Stillinger.  Interfacial Solutions of the Poisson‐Boltzmann Equation , 1961 .

[33]  A. Hodgkin,et al.  The action of calcium on the electrical properties of squid axons , 1957, The Journal of physiology.

[34]  R. Horn,et al.  Molecular Basis of Charge Movement in Voltage-Gated Sodium Channels , 1996, Neuron.

[35]  L. Kolmakova-Partensky,et al.  Intimations of K+ channel structure from a complete functional map of the molecular surface of charybdotoxin. , 1994, Biochemistry.

[36]  Kandiah Manivannan,et al.  Discrete Charges on Biological Membranes , 1992 .

[37]  B. M. Olivera,et al.  Conotoxins. , 1991, The Journal of biological chemistry.

[38]  A. L. Goldin,et al.  A neutral amino acid change in segment IIS4 dramatically alters the gating properties of the voltage-dependent sodium channel. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[39]  H. Guy,et al.  Molecular model of the action potential sodium channel. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[40]  J. Tanaka,et al.  Skeletal Muscle Sodium Channels , 1986 .

[41]  B. Khodorov,et al.  Batrachotoxin as a tool to study voltage-sensitive sodium channels of excitable membranes. , 1985, Progress in biophysics and molecular biology.