The MIRD Schema: from organ to cellular dimensions.

relate with the biologic effects of Auger electron emitters, which deposittheirenergyin a highlylocalizedfashion (12). These observations raise questions regarding the use fulness of mean organ doses in these situations (13—15). As pointedoutby Kassis(13),however,theMIRDSchemais intrinsically able to accommodate most of these complex dosimetricproblemsprovidedthat appropriatebiologic dataareavailable.Thepurposeof thisreportis to review the MIRDSchemaandbrieflyoutlineits capacityto ad dress these issues.