Early epidemiological analysis of the 2019-nCoV outbreak based on a crowdsourced data

Abstract: As the outbreak of novel 2019 coronavirus (2019-nCoV) progresses within China and beyond, there is a need for rapidly available epidemiological data to guide situational awareness and intervention strategies. Here we present an effort to compile epidemiological information on 2019-nCoV from media news reports and a physician community website (dxy.cn) between Jan 20, 2020 and Jan 30, 2020, as the outbreak entered its 7th week. We compiled a line list of patients reported in China and internationally and daily case counts by Chinese province. We describe the demographics, hospitalization and reporting delays for 288 patients, over time and geographically. We find a decrease in case detection lags in provinces outside of Wuhan and internationally, compared to Wuhan, and after Jan 18, 2020, as outbreak awareness increased. The rapid progression of reported cases in different provinces of China is consistent with local transmission beyond Wuhan. The age profile of cases points at a deficit among children under 15 years of age, possibly related to prior immunity with related coronavirus or behavioral differences. Overall, our datasets, which have been publicly available since Jan 21, 2020, align with official reports from Chinese authorities published more than a week later. Availability of publicly available datasets in the early stages of an outbreak is important to encourage disease modeling efforts by independent academic modeling teams and provide robust evidence to guide interventions.

[1]  Benjamin J Cowling,et al.  A comparative epidemiologic analysis of SARS in Hong Kong, Beijing and Taiwan , 2010, BMC infectious diseases.

[2]  Mark A. Miller,et al.  Characterizing the Epidemiology of the 2009 Influenza A/H1N1 Pandemic in Mexico , 2011, PLoS medicine.

[3]  Jing Zhao,et al.  Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia , 2020, The New England journal of medicine.

[4]  J. Robins,et al.  Transmission Dynamics and Control of Severe Acute Respiratory Syndrome , 2003, Science.

[5]  Gerardo Chowell,et al.  Severe respiratory disease concurrent with the circulation of H1N1 influenza. , 2009, The New England journal of medicine.

[6]  L. Yang,et al.  Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak , 2020, bioRxiv.

[7]  Fabrice Carrat,et al.  Comparative age distribution of influenza morbidity and mortality during seasonal influenza epidemics and the 2009 H1N1 pandemic , 2010, BMC infectious diseases.

[8]  Robert J. Taylor,et al.  Global Mortality Estimates for the 2009 Influenza Pandemic from the GLaMOR Project: A Modeling Study , 2013, PLoS medicine.

[9]  E. Lyons,et al.  Pandemic Potential of a Strain of Influenza A (H1N1): Early Findings , 2009, Science.

[10]  Y. Hu,et al.  Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China , 2020, The Lancet.

[11]  Christophe Fraser,et al.  The Epidemiology of Severe Acute Respiratory Syndrome in the 2003 Hong Kong Epidemic: An Analysis of All 1755 Patients , 2004, Annals of Internal Medicine.

[12]  Gerardo Chowell,et al.  Characterizing Ebola Transmission Patterns Based on Internet News Reports. , 2016, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[13]  J. Wallinga,et al.  The incubation period of 2019-nCoV infections among travellers from Wuhan, China , 2020, medRxiv.

[14]  S. Lo,et al.  A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster , 2020, The Lancet.

[15]  Mosoka P. Fallah,et al.  Exposure Patterns Driving Ebola Transmission in West Africa: A Retrospective Observational Study , 2016, PLoS medicine.

[16]  Jean-Paul Chretien,et al.  Using “outbreak science” to strengthen the use of models during epidemics , 2019, Nature Communications.

[17]  Benjamin J Cowling,et al.  Risk for Transportation of 2019 Novel Coronavirus (COVID-19) from Wuhan to Cities in China , 2020, medRxiv.

[18]  C. Reed,et al.  Hospitalizations for Severe Lower Respiratory Tract Infections , 2014, Pediatrics.

[19]  Alan D. Lopez,et al.  Measuring the global burden of disease. , 2013, The New England journal of medicine.